Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25989
MIM: 613472
HGNC: 19703
Ensembl: ENSG00000140474
Variants:
dbSNP: 25989
ClinVar: 25989
TCGA: ENSG00000140474
COSMIC: ULK3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Hedgehog | REACTOME | R-HSA-5358351 |
| Hedgehog 'on' state | REACTOME | R-HSA-5632684 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10804 | imatinib | Chemical | ClinicalAnnotation | associated | PD | 15073101 | |
| PA446171 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Disease | ClinicalAnnotation | associated | PD | 15073101 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36797248 | 2023 | The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome. | 4 |
| 36797248 | 2023 | The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome. | 4 |
| 34190988 | 2021 | Conformational plasticity of the ULK3 kinase domain. | 6 |
| 34190988 | 2021 | Conformational plasticity of the ULK3 kinase domain. | 6 |
| 28877478 | 2017 | The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI. | 26 |
| 28877478 | 2017 | The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI. | 26 |
| 26011858 | 2015 | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins. | 46 |
| 26011858 | 2015 | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins. | 46 |
| 21045733 | 2011 | Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study. | 36 |
| 21045733 | 2011 | Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study. | 36 |
| 19878745 | 2010 | Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. | 49 |
| 20479155 | 2010 | Blood pressure and hypertension are associated with 7 loci in the Japanese population. | 81 |
| 20643644 | 2010 | Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. | 28 |
| 20959405 | 2010 | The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. | 10 |
| 19878745 | 2010 | Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. | 49 |
Citation
Dessen P
ULK3 (unc-51 like kinase 3)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43553/ulk3
