Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ULK3 (unc-51 like kinase 3)

Identity

Alias_namesunc-51-like kinase 3 (C. elegans)
Alias_symbol (synonym)DKFZP434C131
FLJ90566
Other alias-
HGNC (Hugo) ULK3
LocusID (NCBI) 25989
Atlas_Id 43553
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 74836116 and ends at 74843211 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ULK3   19703
Cards
Entrez_Gene (NCBI)ULK3  25989  unc-51 like kinase 3
Aliases
GeneCards (Weizmann)ULK3
Ensembl hg19 (Hinxton)ENSG00000140474 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140474 [Gene_View]  chr15:74836116-74843211 [Contig_View]  ULK3 [Vega]
ICGC DataPortalENSG00000140474
TCGA cBioPortalULK3
AceView (NCBI)ULK3
Genatlas (Paris)ULK3
WikiGenes25989
SOURCE (Princeton)ULK3
Genetics Home Reference (NIH)ULK3
Genomic and cartography
GoldenPath hg38 (UCSC)ULK3  -     chr15:74836116-74843211 -  15q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ULK3  -     15q24.1   [Description]    (hg19-Feb_2009)
EnsemblULK3 - 15q24.1 [CytoView hg19]  ULK3 - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBIULK3 [Mapview hg19]  ULK3 [Mapview hg38]
OMIM613472   
Gene and transcription
Genbank (Entrez)AI677802 AK075047 AK293181 AK293650 AK294241
RefSeq transcript (Entrez)NM_001099436 NM_001284364 NM_001284365
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ULK3
Cluster EST : UnigeneHs.513034 [ NCBI ]
CGAP (NCI)Hs.513034
Alternative Splicing GalleryENSG00000140474
Gene ExpressionULK3 [ NCBI-GEO ]   ULK3 [ EBI - ARRAY_EXPRESS ]   ULK3 [ SEEK ]   ULK3 [ MEM ]
Gene Expression Viewer (FireBrowse)ULK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25989
GTEX Portal (Tissue expression)ULK3
Human Protein AtlasENSG00000140474-ULK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6PHR2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6PHR2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6PHR2
Splice isoforms : SwissVarQ6PHR2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ6PHR2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    MIT    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)MIT (PF04212)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam04212    pfam00069   
Domain families : Smart (EMBL)MIT (SM00745)  S_TKc (SM00220)  
Conserved Domain (NCBI)ULK3
DMDM Disease mutations25989
Blocks (Seattle)ULK3
PDB (SRS)4WZX   
PDB (PDBSum)4WZX   
PDB (IMB)4WZX   
PDB (RSDB)4WZX   
Structural Biology KnowledgeBase4WZX   
SCOP (Structural Classification of Proteins)4WZX   
CATH (Classification of proteins structures)4WZX   
SuperfamilyQ6PHR2
Human Protein Atlas [tissue]ENSG00000140474-ULK3 [tissue]
Peptide AtlasQ6PHR2
HPRD15609
IPIIPI00411818   IPI00795375   IPI00971144   IPI00910978   
Protein Interaction databases
DIP (DOE-UCLA)Q6PHR2
IntAct (EBI)Q6PHR2
FunCoupENSG00000140474
BioGRIDULK3
STRING (EMBL)ULK3
ZODIACULK3
Ontologies - Pathways
QuickGOQ6PHR2
Ontology : AmiGOpre-autophagosomal structure  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagy  negative regulation of smoothened signaling pathway  positive regulation of smoothened signaling pathway  protein autophosphorylation  cellular senescence  ciliary tip  
Ontology : EGO-EBIpre-autophagosomal structure  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  autophagy  negative regulation of smoothened signaling pathway  positive regulation of smoothened signaling pathway  protein autophosphorylation  cellular senescence  ciliary tip  
Pathways : KEGGRegulation of autophagy    mTOR signaling pathway   
NDEx NetworkULK3
Atlas of Cancer Signalling NetworkULK3
Wikipedia pathwaysULK3
Orthology - Evolution
OrthoDB25989
GeneTree (enSembl)ENSG00000140474
Phylogenetic Trees/Animal Genes : TreeFamULK3
HOVERGENQ6PHR2
HOGENOMQ6PHR2
Homologs : HomoloGeneULK3
Homology/Alignments : Family Browser (UCSC)ULK3
Gene fusions - Rearrangements
Tumor Fusion PortalULK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerULK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ULK3
dbVarULK3
ClinVarULK3
1000_GenomesULK3 
Exome Variant ServerULK3
ExAC (Exome Aggregation Consortium)ENSG00000140474
GNOMAD BrowserENSG00000140474
Genetic variants : HAPMAP25989
Genomic Variants (DGV)ULK3 [DGVbeta]
DECIPHERULK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisULK3 
Mutations
ICGC Data PortalULK3 
TCGA Data PortalULK3 
Broad Tumor PortalULK3
OASIS PortalULK3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDULK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ULK3
DgiDB (Drug Gene Interaction Database)ULK3
DoCM (Curated mutations)ULK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ULK3 (select a term)
intoGenULK3
Cancer3DULK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613472   
Orphanet
DisGeNETULK3
MedgenULK3
Genetic Testing Registry ULK3
NextProtQ6PHR2 [Medical]
TSGene25989
GENETestsULK3
Target ValidationULK3
Huge Navigator ULK3 [HugePedia]
snp3D : Map Gene to Disease25989
BioCentury BCIQULK3
ClinGenULK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25989
Chemical/Pharm GKB GenePA134908392
Clinical trialULK3
Miscellaneous
canSAR (ICR)ULK3 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineULK3
EVEXULK3
GoPubMedULK3
iHOPULK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:40:50 CET 2017

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