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ULK4 (unc-51 like kinase 4)

Identity

Alias (NCBI)FAM7C1
REC01035
HGNC (Hugo) ULK4
HGNC Alias symbFLJ20574
REC01035
FAM7C1
HGNC Previous nameunc-51-like kinase 4 (C. elegans)
LocusID (NCBI) 54986
Atlas_Id 43554
Location 3p22.1  [Link to chromosome band 3p22]
Location_base_pair Starts at 41246599 and ends at 41962103 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTS9 (3p14.1)::ULK4 (3p22.1)CCNB1 (5q13.2)::ULK4 (3p22.1)CDKL2 (4q21.1)::ULK4 (3p22.1)
LOC285441 ()::ULK4 (3p22.1)RPSA (3p22.1)::ULK4 (3p22.1)SETD2 (3p21.31)::ULK4 (3p22.1)
STX8 (17p13.1)::ULK4 (3p22.1)TRANK1 (3p22.2)::ULK4 (3p22.1)TRIM24 (7q33)::ULK4 (3p22.1)
ULK4 (3p22.1)::ANO10 (3p22.1)ULK4 (3p22.1)::PAQR3 (4q21.21)ADAMTS9 3p14.1::ULK4 3p22.1
SETD2 3p21.31::ULK4 3p22.1TRIM24 7q33::ULK4 3p22.1ULK4 3p22.1::ANO10 3p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ULK4   15784
Cards
Entrez_Gene (NCBI)ULK4    unc-51 like kinase 4
AliasesFAM7C1; REC01035
GeneCards (Weizmann)ULK4
Ensembl hg19 (Hinxton)ENSG00000168038 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168038 [Gene_View]  ENSG00000168038 [Sequence]  chr3:41246599-41962103 [Contig_View]  ULK4 [Vega]
ICGC DataPortalENSG00000168038
TCGA cBioPortalULK4
AceView (NCBI)ULK4
Genatlas (Paris)ULK4
SOURCE (Princeton)ULK4
Genetics Home Reference (NIH)ULK4
Genomic and cartography
GoldenPath hg38 (UCSC)ULK4  -     chr3:41246599-41962103 -  3p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ULK4  -     3p22.1   [Description]    (hg19-Feb_2009)
GoldenPathULK4 - 3p22.1 [CytoView hg19]  ULK4 - 3p22.1 [CytoView hg38]
ImmunoBaseENSG00000168038
Genome Data Viewer NCBIULK4 [Mapview hg19]  
OMIM617010   
Gene and transcription
Genbank (Entrez)AK000581 AK093396 AK304341 AL133104 AW504756
RefSeq transcript (Entrez)NM_001322500 NM_001322501 NM_017886
Consensus coding sequences : CCDS (NCBI)ULK4
Gene ExpressionULK4 [ NCBI-GEO ]   ULK4 [ EBI - ARRAY_EXPRESS ]   ULK4 [ SEEK ]   ULK4 [ MEM ]
Gene Expression Viewer (FireBrowse)ULK4 [ Firebrowse - Broad ]
GenevisibleExpression of ULK4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54986
GTEX Portal (Tissue expression)ULK4
Human Protein AtlasENSG00000168038-ULK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96C45   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96C45  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96C45
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96C45
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Kinase-like_dom_sf    Prot_kinase_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Conserved Domain (NCBI)ULK4
PDB (RSDB)6TSZ    6U5L   
PDB Europe6TSZ    6U5L   
PDB (PDBSum)6TSZ    6U5L   
PDB (IMB)6TSZ    6U5L   
Structural Biology KnowledgeBase6TSZ    6U5L   
SCOP (Structural Classification of Proteins)6TSZ    6U5L   
CATH (Classification of proteins structures)6TSZ    6U5L   
SuperfamilyQ96C45
AlphaFold pdb e-kbQ96C45   
Human Protein Atlas [tissue]ENSG00000168038-ULK4 [tissue]
HPRD07928
Protein Interaction databases
DIP (DOE-UCLA)Q96C45
IntAct (EBI)Q96C45
BioGRIDULK4
STRING (EMBL)ULK4
ZODIACULK4
Ontologies - Pathways
QuickGOQ96C45
Ontology : AmiGOmicrotubule cytoskeleton organization  ATP binding  protein phosphorylation  regulation of neuron projection development  regulation of MAPK cascade  regulation of JNK cascade  regulation of protein kinase C signaling  protein serine kinase activity  protein threonine kinase activity  regulation of p38MAPK cascade  regulation of neuron migration  
Ontology : EGO-EBImicrotubule cytoskeleton organization  ATP binding  protein phosphorylation  regulation of neuron projection development  regulation of MAPK cascade  regulation of JNK cascade  regulation of protein kinase C signaling  protein serine kinase activity  protein threonine kinase activity  regulation of p38MAPK cascade  regulation of neuron migration  
NDEx NetworkULK4
Atlas of Cancer Signalling NetworkULK4
Wikipedia pathwaysULK4
Orthology - Evolution
OrthoDB54986
GeneTree (enSembl)ENSG00000168038
Phylogenetic Trees/Animal Genes : TreeFamULK4
Homologs : HomoloGeneULK4
Homology/Alignments : Family Browser (UCSC)ULK4
Gene fusions - Rearrangements
Fusion : MitelmanADAMTS9::ULK4 [3p14.1/3p22.1]  
Fusion : MitelmanSETD2::ULK4 [3p21.31/3p22.1]  
Fusion : MitelmanTRIM24::ULK4 [7q33/3p22.1]  
Fusion : MitelmanULK4::ANO10 [3p22.1/3p22.1]  
Fusion : QuiverULK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerULK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ULK4
dbVarULK4
ClinVarULK4
MonarchULK4
1000_GenomesULK4 
Exome Variant ServerULK4
GNOMAD BrowserENSG00000168038
Varsome BrowserULK4
ACMGULK4 variants
VarityQ96C45
Genomic Variants (DGV)ULK4 [DGVbeta]
DECIPHERULK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisULK4 
Mutations
ICGC Data PortalULK4 
TCGA Data PortalULK4 
Broad Tumor PortalULK4
OASIS PortalULK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICULK4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DULK4
Mutations and Diseases : HGMDULK4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaULK4
DgiDB (Drug Gene Interaction Database)ULK4
DoCM (Curated mutations)ULK4
CIViC (Clinical Interpretations of Variants in Cancer)ULK4
Cancer3DULK4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617010   
Orphanet
DisGeNETULK4
MedgenULK4
Genetic Testing Registry ULK4
NextProtQ96C45 [Medical]
GENETestsULK4
Target ValidationULK4
Huge Navigator ULK4 [HugePedia]
ClinGenULK4
Clinical trials, drugs, therapy
MyCancerGenomeULK4
Protein Interactions : CTDULK4
Pharm GKB GenePA134978836
PharosQ96C45
Clinical trialULK4
Miscellaneous
canSAR (ICR)ULK4
HarmonizomeULK4
ARCHS4ULK4
DataMed IndexULK4
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXULK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:39:51 CET 2022

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