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UMPS (uridine monophosphate synthetase)

Identity

Other aliasOPRT
HGNC (Hugo) UMPS
LocusID (NCBI) 7372
Atlas_Id 43555
Location 3q21.2  [Link to chromosome band 3q21]
Location_base_pair Starts at 124449213 and ends at 124468119 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
UMPS (3q21.2) / EVC (4p16.2)UMPS (3q21.2) / KALRN (3q21.2)UMPS (3q21.2) / UMPS (3q21.2)
UMPS 3q21.2 / KALRN 3q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UMPS   12563
Cards
Entrez_Gene (NCBI)UMPS  7372  uridine monophosphate synthetase
AliasesOPRT
GeneCards (Weizmann)UMPS
Ensembl hg19 (Hinxton)ENSG00000114491 [Gene_View]  chr3:124449213-124468119 [Contig_View]  UMPS [Vega]
Ensembl hg38 (Hinxton)ENSG00000114491 [Gene_View]  chr3:124449213-124468119 [Contig_View]  UMPS [Vega]
ICGC DataPortalENSG00000114491
TCGA cBioPortalUMPS
AceView (NCBI)UMPS
Genatlas (Paris)UMPS
WikiGenes7372
SOURCE (Princeton)UMPS
Genetics Home Reference (NIH)UMPS
Genomic and cartography
GoldenPath hg19 (UCSC)UMPS  -     chr3:124449213-124468119 +  3q21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UMPS  -     3q21.2   [Description]    (hg38-Dec_2013)
EnsemblUMPS - 3q21.2 [CytoView hg19]  UMPS - 3q21.2 [CytoView hg38]
Mapping of homologs : NCBIUMPS [Mapview hg19]  UMPS [Mapview hg38]
OMIM258900   613891   
Gene and transcription
Genbank (Entrez)AB062285 AK291306 AL080099 BC000364 BC007511
RefSeq transcript (Entrez)NM_000373
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_017037 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)UMPS
Cluster EST : UnigeneHs.2057 [ NCBI ]
CGAP (NCI)Hs.2057
Alternative Splicing GalleryENSG00000114491
Gene ExpressionUMPS [ NCBI-GEO ]   UMPS [ EBI - ARRAY_EXPRESS ]   UMPS [ SEEK ]   UMPS [ MEM ]
Gene Expression Viewer (FireBrowse)UMPS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7372
GTEX Portal (Tissue expression)UMPS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11172   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11172  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11172
Splice isoforms : SwissVarP11172
Catalytic activity : Enzyme2.4.2.10 [ Enzyme-Expasy ]   2.4.2.102.4.2.10 [ IntEnz-EBI ]   2.4.2.10 [ BRENDA ]   2.4.2.10 [ KEGG ]   
PhosPhoSitePlusP11172
Domaine pattern : Prosite (Expaxy)OMPDECASE (PS00156)    PUR_PYR_PR_TRANSFER (PS00103)   
Domains : Interpro (EBI)Aldolase_TIM    OMPdecase    OMPdecase_AS    OMPdeCOase_dom    OPRT    Or_phspho_trans_dom    PRibTrfase_dom    PRTase-like    RibuloseP-bd_barrel   
Domain families : Pfam (Sanger)OMPdecase (PF00215)    Pribosyltran (PF00156)   
Domain families : Pfam (NCBI)pfam00215    pfam00156   
Domain families : Smart (EMBL)OMPdecase (SM00934)  
Conserved Domain (NCBI)UMPS
DMDM Disease mutations7372
Blocks (Seattle)UMPS
PDB (SRS)2EAW    2JGY    2P1F    2QCC    2QCD    2QCE    2QCF    2QCG    2QCH    2QCL    2QCM    2QCN    2V30    2WNS    3BGG    3BGJ    3BK0    3BVJ    3DBP    3EWU    3EWW    3EWX    3EWY    3EWZ    3EX1    3EX2    3EX3    3EX4    3EX6    3G3D    3G3M    3L0K    3L0N    3MI2    3MO7    3MW7    4HIB    4HKP   
PDB (PDBSum)2EAW    2JGY    2P1F    2QCC    2QCD    2QCE    2QCF    2QCG    2QCH    2QCL    2QCM    2QCN    2V30    2WNS    3BGG    3BGJ    3BK0    3BVJ    3DBP    3EWU    3EWW    3EWX    3EWY    3EWZ    3EX1    3EX2    3EX3    3EX4    3EX6    3G3D    3G3M    3L0K    3L0N    3MI2    3MO7    3MW7    4HIB    4HKP   
PDB (IMB)2EAW    2JGY    2P1F    2QCC    2QCD    2QCE    2QCF    2QCG    2QCH    2QCL    2QCM    2QCN    2V30    2WNS    3BGG    3BGJ    3BK0    3BVJ    3DBP    3EWU    3EWW    3EWX    3EWY    3EWZ    3EX1    3EX2    3EX3    3EX4    3EX6    3G3D    3G3M    3L0K    3L0N    3MI2    3MO7    3MW7    4HIB    4HKP   
PDB (RSDB)2EAW    2JGY    2P1F    2QCC    2QCD    2QCE    2QCF    2QCG    2QCH    2QCL    2QCM    2QCN    2V30    2WNS    3BGG    3BGJ    3BK0    3BVJ    3DBP    3EWU    3EWW    3EWX    3EWY    3EWZ    3EX1    3EX2    3EX3    3EX4    3EX6    3G3D    3G3M    3L0K    3L0N    3MI2    3MO7    3MW7    4HIB    4HKP   
Structural Biology KnowledgeBase2EAW    2JGY    2P1F    2QCC    2QCD    2QCE    2QCF    2QCG    2QCH    2QCL    2QCM    2QCN    2V30    2WNS    3BGG    3BGJ    3BK0    3BVJ    3DBP    3EWU    3EWW    3EWX    3EWY    3EWZ    3EX1    3EX2    3EX3    3EX4    3EX6    3G3D    3G3M    3L0K    3L0N    3MI2    3MO7    3MW7    4HIB    4HKP   
SCOP (Structural Classification of Proteins)2EAW    2JGY    2P1F    2QCC    2QCD    2QCE    2QCF    2QCG    2QCH    2QCL    2QCM    2QCN    2V30    2WNS    3BGG    3BGJ    3BK0    3BVJ    3DBP    3EWU    3EWW    3EWX    3EWY    3EWZ    3EX1    3EX2    3EX3    3EX4    3EX6    3G3D    3G3M    3L0K    3L0N    3MI2    3MO7    3MW7    4HIB    4HKP   
CATH (Classification of proteins structures)2EAW    2JGY    2P1F    2QCC    2QCD    2QCE    2QCF    2QCG    2QCH    2QCL    2QCM    2QCN    2V30    2WNS    3BGG    3BGJ    3BK0    3BVJ    3DBP    3EWU    3EWW    3EWX    3EWY    3EWZ    3EX1    3EX2    3EX3    3EX4    3EX6    3G3D    3G3M    3L0K    3L0N    3MI2    3MO7    3MW7    4HIB    4HKP   
SuperfamilyP11172
Human Protein AtlasENSG00000114491
Peptide AtlasP11172
HPRD02022
IPIIPI00003923   IPI00398067   IPI01013339   IPI00913888   IPI00945920   IPI00945224   IPI00945051   IPI00947553   
Protein Interaction databases
DIP (DOE-UCLA)P11172
IntAct (EBI)P11172
FunCoupENSG00000114491
BioGRIDUMPS
STRING (EMBL)UMPS
ZODIACUMPS
Ontologies - Pathways
QuickGOP11172
Ontology : AmiGOorotate phosphoribosyltransferase activity  orotate phosphoribosyltransferase activity  orotidine-5'-phosphate decarboxylase activity  orotidine-5'-phosphate decarboxylase activity  nucleus  cytoplasm  cytosol  'de novo' pyrimidine nucleobase biosynthetic process  UMP biosynthetic process  female pregnancy  lactation  cellular response to drug  'de novo' UMP biosynthetic process  pyrimidine nucleoside biosynthetic process  
Ontology : EGO-EBIorotate phosphoribosyltransferase activity  orotate phosphoribosyltransferase activity  orotidine-5'-phosphate decarboxylase activity  orotidine-5'-phosphate decarboxylase activity  nucleus  cytoplasm  cytosol  'de novo' pyrimidine nucleobase biosynthetic process  UMP biosynthetic process  female pregnancy  lactation  cellular response to drug  'de novo' UMP biosynthetic process  pyrimidine nucleoside biosynthetic process  
Pathways : KEGGPyrimidine metabolism    Drug metabolism - other enzymes   
NDEx NetworkUMPS
Atlas of Cancer Signalling NetworkUMPS
Wikipedia pathwaysUMPS
Orthology - Evolution
OrthoDB7372
GeneTree (enSembl)ENSG00000114491
Phylogenetic Trees/Animal Genes : TreeFamUMPS
HOVERGENP11172
HOGENOMP11172
Homologs : HomoloGeneUMPS
Homology/Alignments : Family Browser (UCSC)UMPS
Gene fusions - Rearrangements
Fusion : MitelmanUMPS/KALRN [3q21.2/3q21.2]  
Fusion: TCGAUMPS 3q21.2 KALRN 3q21.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUMPS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UMPS
dbVarUMPS
ClinVarUMPS
1000_GenomesUMPS 
Exome Variant ServerUMPS
ExAC (Exome Aggregation Consortium)UMPS (select the gene name)
Genetic variants : HAPMAP7372
Genomic Variants (DGV)UMPS [DGVbeta]
DECIPHER (Syndromes)3:124449213-124468119  ENSG00000114491
CONAN: Copy Number AnalysisUMPS 
Mutations
ICGC Data PortalUMPS 
TCGA Data PortalUMPS 
Broad Tumor PortalUMPS
OASIS PortalUMPS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUMPS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUMPS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UMPS
DgiDB (Drug Gene Interaction Database)UMPS
DoCM (Curated mutations)UMPS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UMPS (select a term)
intoGenUMPS
Cancer3DUMPS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM258900    613891   
Orphanet404   
MedgenUMPS
Genetic Testing Registry UMPS
NextProtP11172 [Medical]
TSGene7372
GENETestsUMPS
Huge Navigator UMPS [HugePedia]
snp3D : Map Gene to Disease7372
BioCentury BCIQUMPS
ClinGenUMPS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7372
Chemical/Pharm GKB GenePA363
Clinical trialUMPS
Miscellaneous
canSAR (ICR)UMPS (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUMPS
EVEXUMPS
GoPubMedUMPS
iHOPUMPS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:33:25 CET 2017

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