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UNC45B (unc-45 myosin chaperone B)

Identity

Alias_namesCMYA4
cardiomyopathy associated 4
unc-45 homolog B (C. elegans)
Alias_symbol (synonym)UNC45
Other aliasCTRCT43
SMUNC45
UNC-45B
HGNC (Hugo) UNC45B
LocusID (NCBI) 146862
Atlas_Id 75484
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 35147817 and ends at 35189345 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KANSL1 (17q21.31) / UNC45B (17q12)PSMD3 (17q21.1) / UNC45B (17q12)UNC45B (17q12) / EIF2AK1 (7p22.1)
PSMD3 UNC45BKIAA1267 UNC45B

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UNC45B   14304
Cards
Entrez_Gene (NCBI)UNC45B  146862  unc-45 myosin chaperone B
AliasesCMYA4; CTRCT43; SMUNC45; UNC-45B; 
UNC45
GeneCards (Weizmann)UNC45B
Ensembl hg19 (Hinxton)ENSG00000141161 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141161 [Gene_View]  chr17:35147817-35189345 [Contig_View]  UNC45B [Vega]
ICGC DataPortalENSG00000141161
TCGA cBioPortalUNC45B
AceView (NCBI)UNC45B
Genatlas (Paris)UNC45B
WikiGenes146862
SOURCE (Princeton)UNC45B
Genetics Home Reference (NIH)UNC45B
Genomic and cartography
GoldenPath hg38 (UCSC)UNC45B  -     chr17:35147817-35189345 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UNC45B  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblUNC45B - 17q12 [CytoView hg19]  UNC45B - 17q12 [CytoView hg38]
Mapping of homologs : NCBIUNC45B [Mapview hg19]  UNC45B [Mapview hg38]
OMIM611220   616279   
Gene and transcription
Genbank (Entrez)AF539794 AK095929 AL832355 AL833281 BC101062
RefSeq transcript (Entrez)NM_001033576 NM_001267052 NM_001308281 NM_173167
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UNC45B
Cluster EST : UnigeneHs.379636 [ NCBI ]
CGAP (NCI)Hs.379636
Alternative Splicing GalleryENSG00000141161
Gene ExpressionUNC45B [ NCBI-GEO ]   UNC45B [ EBI - ARRAY_EXPRESS ]   UNC45B [ SEEK ]   UNC45B [ MEM ]
Gene Expression Viewer (FireBrowse)UNC45B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)146862
GTEX Portal (Tissue expression)UNC45B
Human Protein AtlasENSG00000141161-UNC45B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWX7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWX7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWX7
Splice isoforms : SwissVarQ8IWX7
PhosPhoSitePlusQ8IWX7
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Armadillo    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat    UCS_central_dom   
Domain families : Pfam (Sanger)UNC45-central (PF11701)   
Domain families : Pfam (NCBI)pfam11701   
Domain families : Smart (EMBL)ARM (SM00185)  TPR (SM00028)  
Conserved Domain (NCBI)UNC45B
DMDM Disease mutations146862
Blocks (Seattle)UNC45B
SuperfamilyQ8IWX7
Human Protein Atlas [tissue]ENSG00000141161-UNC45B [tissue]
Peptide AtlasQ8IWX7
HPRD10840
IPIIPI00217428   IPI00644184   IPI00651724   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWX7
IntAct (EBI)Q8IWX7
FunCoupENSG00000141161
BioGRIDUNC45B
STRING (EMBL)UNC45B
ZODIACUNC45B
Ontologies - Pathways
QuickGOQ8IWX7
Ontology : AmiGOlens development in camera-type eye  protein binding  cytosol  muscle organ development  cell differentiation  Hsp90 protein binding  chaperone-mediated protein folding  
Ontology : EGO-EBIlens development in camera-type eye  protein binding  cytosol  muscle organ development  cell differentiation  Hsp90 protein binding  chaperone-mediated protein folding  
NDEx NetworkUNC45B
Atlas of Cancer Signalling NetworkUNC45B
Wikipedia pathwaysUNC45B
Orthology - Evolution
OrthoDB146862
GeneTree (enSembl)ENSG00000141161
Phylogenetic Trees/Animal Genes : TreeFamUNC45B
HOVERGENQ8IWX7
HOGENOMQ8IWX7
Homologs : HomoloGeneUNC45B
Homology/Alignments : Family Browser (UCSC)UNC45B
Gene fusions - Rearrangements
Fusion: TCGA_MDACCPSMD3 UNC45B
Fusion: TCGA_MDACCKIAA1267 UNC45B
Tumor Fusion PortalUNC45B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUNC45B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UNC45B
dbVarUNC45B
ClinVarUNC45B
1000_GenomesUNC45B 
Exome Variant ServerUNC45B
ExAC (Exome Aggregation Consortium)ENSG00000141161
GNOMAD BrowserENSG00000141161
Genetic variants : HAPMAP146862
Genomic Variants (DGV)UNC45B [DGVbeta]
DECIPHERUNC45B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUNC45B 
Mutations
ICGC Data PortalUNC45B 
TCGA Data PortalUNC45B 
Broad Tumor PortalUNC45B
OASIS PortalUNC45B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUNC45B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUNC45B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UNC45B
DgiDB (Drug Gene Interaction Database)UNC45B
DoCM (Curated mutations)UNC45B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UNC45B (select a term)
intoGenUNC45B
Cancer3DUNC45B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611220    616279   
Orphanet23422    14008   
DisGeNETUNC45B
MedgenUNC45B
Genetic Testing Registry UNC45B
NextProtQ8IWX7 [Medical]
TSGene146862
GENETestsUNC45B
Target ValidationUNC45B
Huge Navigator UNC45B [HugePedia]
snp3D : Map Gene to Disease146862
BioCentury BCIQUNC45B
ClinGenUNC45B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD146862
Chemical/Pharm GKB GenePA26655
Clinical trialUNC45B
Miscellaneous
canSAR (ICR)UNC45B (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUNC45B
EVEXUNC45B
GoPubMedUNC45B
iHOPUNC45B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:37:13 CET 2017

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