UNC5A (unc-5 netrin receptor A)

2007-02-01  

Identity

HGNC
LOCATION
5q35.2
LOCUSID
ALIAS
UNC5H1
FUSION GENES

Other Information

Locus ID:

NCBI: 90249
MIM: 607869
HGNC: 12567
Ensembl: ENSG00000113763

Variants:

dbSNP: 90249
ClinVar: 90249
TCGA: ENSG00000113763
COSMIC: UNC5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113763ENST00000329542Q6ZN44
ENSG00000113763ENST00000509580H0Y8R2
ENSG00000113763ENST00000513890H0Y9G2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Netrin mediated repulsion signalsREACTOMER-HSA-418886

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
155731192004Netrin-1 and its receptors in tumorigenesis.83
126550552003The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.55
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
203728002010Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.10
246762802014The Fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis.4
247375862014DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer.4
287831792017Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus.2
287103822017Netrin-1 promotes glioma growth by activating NF-κB via UNC5A.1
292776142018Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.1

Citation

Dessen P

UNC5A (unc-5 netrin receptor A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43649/unc5a