UNC5B (unc-5 netrin receptor B)

2007-02-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
UNC5H2,p53RDL1
FUSION GENES

Other Information

Locus ID:

NCBI: 219699
MIM: 607870
HGNC: 12568
Ensembl: ENSG00000107731

Variants:

dbSNP: 219699
ClinVar: 219699
TCGA: ENSG00000107731
COSMIC: UNC5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107731ENST00000335350Q8IZJ1
ENSG00000107731ENST00000373192Q8IZJ1

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Netrin mediated repulsion signalsREACTOMER-HSA-418886

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
245841182014Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.81
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
212389232011Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B.62
126550552003The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.55
187191022008Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.55
211726532010The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.44
184698072008Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.43
192736162009Unc5B associates with LARG to mediate the action of repulsive guidance molecule.43
233125172013Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.43

Citation

Dessen P

UNC5B (unc-5 netrin receptor B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46461/unc5b