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UNC5B (unc-5 netrin receptor B)

Identity

Alias_namesunc5 (C.elegans homolog) b
unc-5 homolog B (C. elegans)
Alias_symbol (synonym)UNC5H2
p53RDL1
Other alias
HGNC (Hugo) UNC5B
LocusID (NCBI) 219699
Atlas_Id 46461
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 71212535 and ends at 71302878 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RBM25 (14q24.2) / UNC5B (10q22.1)SAMM50 (22q13.31) / UNC5B (10q22.1)UNC5B (10q22.1) / UNC5B (10q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UNC5B   12568
Cards
Entrez_Gene (NCBI)UNC5B  219699  unc-5 netrin receptor B
AliasesUNC5H2; p53RDL1
GeneCards (Weizmann)UNC5B
Ensembl hg19 (Hinxton)ENSG00000107731 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107731 [Gene_View]  chr10:71212535-71302878 [Contig_View]  UNC5B [Vega]
ICGC DataPortalENSG00000107731
TCGA cBioPortalUNC5B
AceView (NCBI)UNC5B
Genatlas (Paris)UNC5B
WikiGenes219699
SOURCE (Princeton)UNC5B
Genetics Home Reference (NIH)UNC5B
Genomic and cartography
GoldenPath hg38 (UCSC)UNC5B  -     chr10:71212535-71302878 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UNC5B  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblUNC5B - 10q22.1 [CytoView hg19]  UNC5B - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBIUNC5B [Mapview hg19]  UNC5B [Mapview hg38]
OMIM607870   
Gene and transcription
Genbank (Entrez)AB096256 AK022859 AK094595 AK128132 AL049370
RefSeq transcript (Entrez)NM_001244889 NM_170744
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UNC5B
Cluster EST : UnigeneHs.522997 [ NCBI ]
CGAP (NCI)Hs.522997
Alternative Splicing GalleryENSG00000107731
Gene ExpressionUNC5B [ NCBI-GEO ]   UNC5B [ EBI - ARRAY_EXPRESS ]   UNC5B [ SEEK ]   UNC5B [ MEM ]
Gene Expression Viewer (FireBrowse)UNC5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)219699
GTEX Portal (Tissue expression)UNC5B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZJ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZJ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZJ1
Splice isoforms : SwissVarQ8IZJ1
PhosPhoSitePlusQ8IZJ1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TSP1 (PS50092)    ZU5 (PS51145)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    TSP1_rpt    UPA    ZU5_dom   
Domain families : Pfam (Sanger)Death (PF00531)    I-set (PF07679)    TSP_1 (PF00090)    UPA (PF17217)    ZU5 (PF00791)   
Domain families : Pfam (NCBI)pfam00531    pfam07679    pfam00090    pfam17217    pfam00791   
Domain families : Smart (EMBL)DEATH (SM00005)  IG (SM00409)  IGc2 (SM00408)  TSP1 (SM00209)  ZU5 (SM00218)  
Conserved Domain (NCBI)UNC5B
DMDM Disease mutations219699
Blocks (Seattle)UNC5B
SuperfamilyQ8IZJ1
Human Protein AtlasENSG00000107731
Peptide AtlasQ8IZJ1
HPRD08487
IPIIPI00328431   IPI00383609   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZJ1
IntAct (EBI)Q8IZJ1
FunCoupENSG00000107731
BioGRIDUNC5B
STRING (EMBL)UNC5B
ZODIACUNC5B
Ontologies - Pathways
QuickGOQ8IZJ1
Ontology : AmiGOangiogenesis  protein binding  plasma membrane  apoptotic process  signal transduction  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  anterior/posterior axon guidance  negative regulation of neuron apoptotic process  membrane raft  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIangiogenesis  protein binding  plasma membrane  apoptotic process  signal transduction  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  anterior/posterior axon guidance  negative regulation of neuron apoptotic process  membrane raft  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGAxon guidance   
NDEx NetworkUNC5B
Atlas of Cancer Signalling NetworkUNC5B
Wikipedia pathwaysUNC5B
Orthology - Evolution
OrthoDB219699
GeneTree (enSembl)ENSG00000107731
Phylogenetic Trees/Animal Genes : TreeFamUNC5B
HOVERGENQ8IZJ1
HOGENOMQ8IZJ1
Homologs : HomoloGeneUNC5B
Homology/Alignments : Family Browser (UCSC)UNC5B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUNC5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UNC5B
dbVarUNC5B
ClinVarUNC5B
1000_GenomesUNC5B 
Exome Variant ServerUNC5B
ExAC (Exome Aggregation Consortium)UNC5B (select the gene name)
Genetic variants : HAPMAP219699
Genomic Variants (DGV)UNC5B [DGVbeta]
DECIPHERUNC5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUNC5B 
Mutations
ICGC Data PortalUNC5B 
TCGA Data PortalUNC5B 
Broad Tumor PortalUNC5B
OASIS PortalUNC5B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUNC5B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUNC5B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UNC5B
DgiDB (Drug Gene Interaction Database)UNC5B
DoCM (Curated mutations)UNC5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UNC5B (select a term)
intoGenUNC5B
Cancer3DUNC5B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607870   
Orphanet
MedgenUNC5B
Genetic Testing Registry UNC5B
NextProtQ8IZJ1 [Medical]
TSGene219699
GENETestsUNC5B
Target ValidationUNC5B
Huge Navigator UNC5B [HugePedia]
snp3D : Map Gene to Disease219699
BioCentury BCIQUNC5B
ClinGenUNC5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD219699
Chemical/Pharm GKB GenePA37205
Clinical trialUNC5B
Miscellaneous
canSAR (ICR)UNC5B (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUNC5B
EVEXUNC5B
GoPubMedUNC5B
iHOPUNC5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:11:13 CEST 2017

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