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UNC5C (unc-5 netrin receptor C)

Identity

Alias_namesunc5 (C.elegans homolog) c
unc-5 homolog C (C. elegans)
Other aliasUNC5H3
HGNC (Hugo) UNC5C
LocusID (NCBI) 8633
Atlas_Id 45616
Location 4q22.3  [Link to chromosome band 4q22]
Location_base_pair Starts at 95162505 and ends at 95549210 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DUS2 (16q22.1) / UNC5C (4q22.3)UNC5C (4q22.3) / LIN7C (11p14.1)UNC5C (4q22.3) / RAP1GDS1 (4q23)
UNC5C (4q22.3) / UNC5C (4q22.3)DUS2L UNC5C 4q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UNC5C   12569
Cards
Entrez_Gene (NCBI)UNC5C  8633  unc-5 netrin receptor C
AliasesUNC5H3
GeneCards (Weizmann)UNC5C
Ensembl hg19 (Hinxton)ENSG00000182168 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182168 [Gene_View]  chr4:95162505-95549210 [Contig_View]  UNC5C [Vega]
ICGC DataPortalENSG00000182168
TCGA cBioPortalUNC5C
AceView (NCBI)UNC5C
Genatlas (Paris)UNC5C
WikiGenes8633
SOURCE (Princeton)UNC5C
Genetics Home Reference (NIH)UNC5C
Genomic and cartography
GoldenPath hg38 (UCSC)UNC5C  -     chr4:95162505-95549210 -  4q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UNC5C  -     4q22.3   [Description]    (hg19-Feb_2009)
EnsemblUNC5C - 4q22.3 [CytoView hg19]  UNC5C - 4q22.3 [CytoView hg38]
Mapping of homologs : NCBIUNC5C [Mapview hg19]  UNC5C [Mapview hg38]
OMIM603610   
Gene and transcription
Genbank (Entrez)AF055634 AK022487 AK290500 AK308421 BC034747
RefSeq transcript (Entrez)NM_003728
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UNC5C
Cluster EST : UnigeneHs.388565 [ NCBI ]
CGAP (NCI)Hs.388565
Alternative Splicing GalleryENSG00000182168
Gene ExpressionUNC5C [ NCBI-GEO ]   UNC5C [ EBI - ARRAY_EXPRESS ]   UNC5C [ SEEK ]   UNC5C [ MEM ]
Gene Expression Viewer (FireBrowse)UNC5C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8633
GTEX Portal (Tissue expression)UNC5C
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95185   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95185  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95185
Splice isoforms : SwissVarO95185
PhosPhoSitePlusO95185
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TSP1 (PS50092)    ZU5 (PS51145)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    TSP1_rpt    UPA    ZU5_dom   
Domain families : Pfam (Sanger)Death (PF00531)    I-set (PF07679)    TSP_1 (PF00090)    UPA (PF17217)    ZU5 (PF00791)   
Domain families : Pfam (NCBI)pfam00531    pfam07679    pfam00090    pfam17217    pfam00791   
Domain families : Smart (EMBL)DEATH (SM00005)  IG (SM00409)  IGc2 (SM00408)  TSP1 (SM00209)  ZU5 (SM00218)  
Conserved Domain (NCBI)UNC5C
DMDM Disease mutations8633
Blocks (Seattle)UNC5C
SuperfamilyO95185
Human Protein AtlasENSG00000182168
Peptide AtlasO95185
HPRD04678
IPIIPI00293757   IPI00470749   IPI00939518   IPI00964794   IPI00965674   
Protein Interaction databases
DIP (DOE-UCLA)O95185
IntAct (EBI)O95185
FunCoupENSG00000182168
BioGRIDUNC5C
STRING (EMBL)UNC5C
ZODIACUNC5C
Ontologies - Pathways
QuickGOO95185
Ontology : AmiGOnetrin receptor activity  plasma membrane  apoptotic process  axon guidance  brain development  integral component of membrane  cell junction  regulation of cell migration  anterior/posterior axon guidance  netrin-activated signaling pathway  neuron projection  positive regulation of apoptotic process  synapse  
Ontology : EGO-EBInetrin receptor activity  plasma membrane  apoptotic process  axon guidance  brain development  integral component of membrane  cell junction  regulation of cell migration  anterior/posterior axon guidance  netrin-activated signaling pathway  neuron projection  positive regulation of apoptotic process  synapse  
Pathways : KEGGAxon guidance   
NDEx NetworkUNC5C
Atlas of Cancer Signalling NetworkUNC5C
Wikipedia pathwaysUNC5C
Orthology - Evolution
OrthoDB8633
GeneTree (enSembl)ENSG00000182168
Phylogenetic Trees/Animal Genes : TreeFamUNC5C
HOVERGENO95185
HOGENOMO95185
Homologs : HomoloGeneUNC5C
Homology/Alignments : Family Browser (UCSC)UNC5C
Gene fusions - Rearrangements
Fusion : MitelmanDUS2/UNC5C [16q22.1/4q22.3]  [t(4;16)(q22;q22)]  
Fusion: TCGADUS2L UNC5C 4q22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUNC5C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UNC5C
dbVarUNC5C
ClinVarUNC5C
1000_GenomesUNC5C 
Exome Variant ServerUNC5C
ExAC (Exome Aggregation Consortium)UNC5C (select the gene name)
Genetic variants : HAPMAP8633
Genomic Variants (DGV)UNC5C [DGVbeta]
DECIPHERUNC5C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUNC5C 
Mutations
ICGC Data PortalUNC5C 
TCGA Data PortalUNC5C 
Broad Tumor PortalUNC5C
OASIS PortalUNC5C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUNC5C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUNC5C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UNC5C
DgiDB (Drug Gene Interaction Database)UNC5C
DoCM (Curated mutations)UNC5C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UNC5C (select a term)
intoGenUNC5C
Cancer3DUNC5C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603610   
Orphanet
MedgenUNC5C
Genetic Testing Registry UNC5C
NextProtO95185 [Medical]
TSGene8633
GENETestsUNC5C
Target ValidationUNC5C
Huge Navigator UNC5C [HugePedia]
snp3D : Map Gene to Disease8633
BioCentury BCIQUNC5C
ClinGenUNC5C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8633
Chemical/Pharm GKB GenePA37206
Clinical trialUNC5C
Miscellaneous
canSAR (ICR)UNC5C (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUNC5C
EVEXUNC5C
GoPubMedUNC5C
iHOPUNC5C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:00 CEST 2017

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