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UNC5D (unc-5 netrin receptor D)

Identity

Alias_namesunc-5 homolog D (C. elegans)
Alias_symbol (synonym)KIAA1777
Unc5h4
Other aliasPRO34692
HGNC (Hugo) UNC5D
LocusID (NCBI) 137970
Atlas_Id 53800
Location 8p12  [Link to chromosome band 8p12]
Location_base_pair Starts at 35092975 and ends at 35652181 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACOXL (2q13) / UNC5D (8p12)ANO1 (11q13.3) / UNC5D (8p12)DHX40 (17q23.1) / UNC5D (8p12)
FAM222B (17q11.2) / UNC5D (8p12)IKBKB (8p11.21) / UNC5D (8p12)MORN3 (12q24.31) / UNC5D (8p12)
PEBP4 (8p21.3) / UNC5D (8p12)POLB (8p11.21) / UNC5D (8p12)RAB11FIP1 (8p11.23) / UNC5D (8p12)
TPX2 (20q11.21) / UNC5D (8p12)UNC5D (8p12) / EIF4EBP1 (8p11.23)UNC5D (8p12) / PRKAR2B (7q22.3)
UNC5D (8p12) / TEX2 (17q23.3)UNC5D (8p12) / TMOD2 (15q21.2)ACOXL 2q13 / UNC5D 8p12
ANO1 11q13.3 / UNC5D 8p12C17orf63 UNC5D 8p12DHX40 17q23.1 / UNC5D 8p12
IKBKB 8p11.21 / UNC5D 8p12PEBP4 8p21.3 / UNC5D 8p12POLB 8p11.21 / UNC5D 8p12
RAB11FIP1 8p11.23 / UNC5D 8p12TPX2 20q11.21 / UNC5D 8p12UNC5D 8p12 / EIF4EBP1 8p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UNC5D   18634
Cards
Entrez_Gene (NCBI)UNC5D  137970  unc-5 netrin receptor D
AliasesPRO34692; Unc5h4
GeneCards (Weizmann)UNC5D
Ensembl hg19 (Hinxton)ENSG00000156687 [Gene_View]  chr8:35092975-35652181 [Contig_View]  UNC5D [Vega]
Ensembl hg38 (Hinxton)ENSG00000156687 [Gene_View]  chr8:35092975-35652181 [Contig_View]  UNC5D [Vega]
ICGC DataPortalENSG00000156687
TCGA cBioPortalUNC5D
AceView (NCBI)UNC5D
Genatlas (Paris)UNC5D
WikiGenes137970
SOURCE (Princeton)UNC5D
Genetics Home Reference (NIH)UNC5D
Genomic and cartography
GoldenPath hg19 (UCSC)UNC5D  -     chr8:35092975-35652181 +  8p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UNC5D  -     8p12   [Description]    (hg38-Dec_2013)
EnsemblUNC5D - 8p12 [CytoView hg19]  UNC5D - 8p12 [CytoView hg38]
Mapping of homologs : NCBIUNC5D [Mapview hg19]  UNC5D [Mapview hg38]
OMIM616466   
Gene and transcription
Genbank (Entrez)AB055056 AB073394 AI004193 AK092313 AK122610
RefSeq transcript (Entrez)NM_001322818 NM_080872
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)UNC5D
Cluster EST : UnigeneHs.238889 [ NCBI ]
CGAP (NCI)Hs.238889
Alternative Splicing GalleryENSG00000156687
Gene ExpressionUNC5D [ NCBI-GEO ]   UNC5D [ EBI - ARRAY_EXPRESS ]   UNC5D [ SEEK ]   UNC5D [ MEM ]
Gene Expression Viewer (FireBrowse)UNC5D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)137970
GTEX Portal (Tissue expression)UNC5D
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXZ4
Splice isoforms : SwissVarQ6UXZ4
PhosPhoSitePlusQ6UXZ4
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TSP1 (PS50092)    ZU5 (PS51145)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    TSP1_rpt    ZU5_dom   
Domain families : Pfam (Sanger)Death (PF00531)    I-set (PF07679)    TSP_1 (PF00090)    ZU5 (PF00791)   
Domain families : Pfam (NCBI)pfam00531    pfam07679    pfam00090    pfam00791   
Domain families : Smart (EMBL)DEATH (SM00005)  IGc2 (SM00408)  TSP1 (SM00209)  
Conserved Domain (NCBI)UNC5D
DMDM Disease mutations137970
Blocks (Seattle)UNC5D
SuperfamilyQ6UXZ4
Human Protein AtlasENSG00000156687
Peptide AtlasQ6UXZ4
HPRD11661
IPIIPI00470696   IPI00103755   IPI00925643   IPI00925008   IPI00925223   IPI00924577   
Protein Interaction databases
DIP (DOE-UCLA)Q6UXZ4
IntAct (EBI)Q6UXZ4
FunCoupENSG00000156687
BioGRIDUNC5D
STRING (EMBL)UNC5D
ZODIACUNC5D
Ontologies - Pathways
QuickGOQ6UXZ4
Ontology : AmiGOplasma membrane  apoptotic process  signal transduction  axon guidance  cell surface  integral component of membrane  pyramidal neuron differentiation  cell-cell adhesion  regulation of neuron migration  
Ontology : EGO-EBIplasma membrane  apoptotic process  signal transduction  axon guidance  cell surface  integral component of membrane  pyramidal neuron differentiation  cell-cell adhesion  regulation of neuron migration  
Pathways : KEGGAxon guidance   
NDEx NetworkUNC5D
Atlas of Cancer Signalling NetworkUNC5D
Wikipedia pathwaysUNC5D
Orthology - Evolution
OrthoDB137970
GeneTree (enSembl)ENSG00000156687
Phylogenetic Trees/Animal Genes : TreeFamUNC5D
HOVERGENQ6UXZ4
HOGENOMQ6UXZ4
Homologs : HomoloGeneUNC5D
Homology/Alignments : Family Browser (UCSC)UNC5D
Gene fusions - Rearrangements
Fusion : MitelmanANO1/UNC5D [11q13.3/8p12]  [t(8;11)(p12;q13)]  
Fusion : MitelmanDHX40/UNC5D [17q23.1/8p12]  [t(8;17)(p12;q23)]  
Fusion : MitelmanFAM222B/UNC5D [17q11.2/8p12]  [t(8;17)(p12;q11)]  
Fusion : MitelmanIKBKB/UNC5D [8p11.21/8p12]  [t(8;8)(p11;p12)]  
Fusion : MitelmanPEBP4/UNC5D [8p21.3/8p12]  [t(8;8)(p12;p21)]  
Fusion : MitelmanPOLB/UNC5D [8p11.21/8p12]  [t(8;8)(p11;p12)]  
Fusion : MitelmanRAB11FIP1/UNC5D [8p11.23/8p12]  [t(8;8)(p11;p12)]  
Fusion : MitelmanTPX2/UNC5D [20q11.21/8p12]  [t(8;20)(p12;q11)]  
Fusion : MitelmanUNC5D/EIF4EBP1 [8p12/8p11.23]  [t(8;8)(p11;p12)]  
Fusion: TCGAACOXL 2q13 UNC5D 8p12 BLCA
Fusion: TCGAANO1 11q13.3 UNC5D 8p12 BRCA
Fusion: TCGAC17orf63 UNC5D 8p12 LUAD
Fusion: TCGADHX40 17q23.1 UNC5D 8p12 LUAD
Fusion: TCGAIKBKB 8p11.21 UNC5D 8p12 BLCA
Fusion: TCGAPEBP4 8p21.3 UNC5D 8p12 BRCA
Fusion: TCGAPOLB 8p11.21 UNC5D 8p12 LUAD
Fusion: TCGARAB11FIP1 8p11.23 UNC5D 8p12 BRCA
Fusion: TCGATPX2 20q11.21 UNC5D 8p12 HNSC
Fusion: TCGAUNC5D 8p12 EIF4EBP1 8p11.23 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUNC5D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UNC5D
dbVarUNC5D
ClinVarUNC5D
1000_GenomesUNC5D 
Exome Variant ServerUNC5D
ExAC (Exome Aggregation Consortium)UNC5D (select the gene name)
Genetic variants : HAPMAP137970
Genomic Variants (DGV)UNC5D [DGVbeta]
DECIPHER (Syndromes)8:35092975-35652181  ENSG00000156687
CONAN: Copy Number AnalysisUNC5D 
Mutations
ICGC Data PortalUNC5D 
TCGA Data PortalUNC5D 
Broad Tumor PortalUNC5D
OASIS PortalUNC5D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUNC5D  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUNC5D
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UNC5D
DgiDB (Drug Gene Interaction Database)UNC5D
DoCM (Curated mutations)UNC5D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UNC5D (select a term)
intoGenUNC5D
Cancer3DUNC5D(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616466   
Orphanet
MedgenUNC5D
Genetic Testing Registry UNC5D
NextProtQ6UXZ4 [Medical]
TSGene137970
GENETestsUNC5D
Huge Navigator UNC5D [HugePedia]
snp3D : Map Gene to Disease137970
BioCentury BCIQUNC5D
ClinGenUNC5D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD137970
Chemical/Pharm GKB GenePA38612
Clinical trialUNC5D
Miscellaneous
canSAR (ICR)UNC5D (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUNC5D
EVEXUNC5D
GoPubMedUNC5D
iHOPUNC5D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:23 CEST 2017

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