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UNC5D (unc-5 netrin receptor D)

Identity

Alias (NCBI)PRO34692
Unc5h4
HGNC (Hugo) UNC5D
HGNC Alias symbKIAA1777
Unc5h4
HGNC Alias nameNetrin receptor UNC5D
 Protein unc-5 homolog 4
 Protein unc-5 homolog D
HGNC Previous nameunc-5 homolog D (C. elegans)
LocusID (NCBI) 137970
Atlas_Id 53800
Location 8p12  [Link to chromosome band 8p12]
Location_base_pair Starts at 35235475 and ends at 35796540 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACOXL (2q13) / UNC5D (8p12)ANO1 (11q13.3) / UNC5D (8p12)DHX40 (17q23.1) / UNC5D (8p12)
FAM222B (17q11.2) / UNC5D (8p12)IKBKB (8p11.21) / UNC5D (8p12)MORN3 (12q24.31) / UNC5D (8p12)
PEBP4 (8p21.3) / UNC5D (8p12)POLB (8p11.21) / UNC5D (8p12)RAB11FIP1 (8p11.23) / UNC5D (8p12)
TPX2 (20q11.21) / UNC5D (8p12)UNC5D (8p12) / EIF4EBP1 (8p11.23)UNC5D (8p12) / PRKAR2B (7q22.3)
UNC5D (8p12) / TEX2 (17q23.3)UNC5D (8p12) / TMOD2 (15q21.2)ACOXL 2q13 / UNC5D 8p12
ANO1 11q13.3 / UNC5D 8p12C17orf63 UNC5D 8p12DHX40 17q23.1 / UNC5D 8p12
IKBKB 8p11.21 / UNC5D 8p12PEBP4 8p21.3 / UNC5D 8p12POLB 8p11.21 / UNC5D 8p12
RAB11FIP1 8p11.23 / UNC5D 8p12TPX2 20q11.21 / UNC5D 8p12UNC5D 8p12 / EIF4EBP1 8p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)UNC5D   18634
Cards
Entrez_Gene (NCBI)UNC5D    unc-5 netrin receptor D
AliasesPRO34692; Unc5h4
GeneCards (Weizmann)UNC5D
Ensembl hg19 (Hinxton)ENSG00000156687 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156687 [Gene_View]  ENSG00000156687 [Sequence]  chr8:35235475-35796540 [Contig_View]  UNC5D [Vega]
ICGC DataPortalENSG00000156687
TCGA cBioPortalUNC5D
AceView (NCBI)UNC5D
Genatlas (Paris)UNC5D
SOURCE (Princeton)UNC5D
Genetics Home Reference (NIH)UNC5D
Genomic and cartography
GoldenPath hg38 (UCSC)UNC5D  -     chr8:35235475-35796540 +  8p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UNC5D  -     8p12   [Description]    (hg19-Feb_2009)
GoldenPathUNC5D - 8p12 [CytoView hg19]  UNC5D - 8p12 [CytoView hg38]
ImmunoBaseENSG00000156687
Genome Data Viewer NCBIUNC5D [Mapview hg19]  
OMIM616466   
Gene and transcription
Genbank (Entrez)AB055056 AB073394 AI004193 AK092313 AK122610
RefSeq transcript (Entrez)NM_001322818 NM_080872
Consensus coding sequences : CCDS (NCBI)UNC5D
Gene ExpressionUNC5D [ NCBI-GEO ]   UNC5D [ EBI - ARRAY_EXPRESS ]   UNC5D [ SEEK ]   UNC5D [ MEM ]
Gene Expression Viewer (FireBrowse)UNC5D [ Firebrowse - Broad ]
GenevisibleExpression of UNC5D in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)137970
GTEX Portal (Tissue expression)UNC5D
Human Protein AtlasENSG00000156687-UNC5D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXZ4
PhosPhoSitePlusQ6UXZ4
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TSP1 (PS50092)    ZU5 (PS51145)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    TSP1_rpt    TSP1_rpt_sf    UNC5    UNC5D_Death    UPA    ZU5_dom   
Domain families : Pfam (Sanger)Death (PF00531)    I-set (PF07679)    TSP_1 (PF00090)    UPA (PF17217)    ZU5 (PF00791)   
Domain families : Pfam (NCBI)pfam00531    pfam07679    pfam00090    pfam17217    pfam00791   
Domain families : Smart (EMBL)DEATH (SM00005)  IG (SM00409)  IGc2 (SM00408)  TSP1 (SM00209)  ZU5 (SM00218)  
Conserved Domain (NCBI)UNC5D
SuperfamilyQ6UXZ4
AlphaFold pdb e-kbQ6UXZ4   
Human Protein Atlas [tissue]ENSG00000156687-UNC5D [tissue]
HPRD11661
Protein Interaction databases
DIP (DOE-UCLA)Q6UXZ4
IntAct (EBI)Q6UXZ4
BioGRIDUNC5D
STRING (EMBL)UNC5D
ZODIACUNC5D
Ontologies - Pathways
QuickGOQ6UXZ4
Ontology : AmiGOnetrin receptor activity  plasma membrane  apoptotic process  axon guidance  cell surface  integral component of membrane  pyramidal neuron differentiation  netrin-activated signaling pathway  cell-cell adhesion via plasma-membrane adhesion molecules  regulation of neuron migration  
Ontology : EGO-EBInetrin receptor activity  plasma membrane  apoptotic process  axon guidance  cell surface  integral component of membrane  pyramidal neuron differentiation  netrin-activated signaling pathway  cell-cell adhesion via plasma-membrane adhesion molecules  regulation of neuron migration  
Pathways : KEGGAxon guidance   
NDEx NetworkUNC5D
Atlas of Cancer Signalling NetworkUNC5D
Wikipedia pathwaysUNC5D
Orthology - Evolution
OrthoDB137970
GeneTree (enSembl)ENSG00000156687
Phylogenetic Trees/Animal Genes : TreeFamUNC5D
Homologs : HomoloGeneUNC5D
Homology/Alignments : Family Browser (UCSC)UNC5D
Gene fusions - Rearrangements
Fusion : MitelmanANO1/UNC5D [11q13.3/8p12]  
Fusion : MitelmanDHX40/UNC5D [17q23.1/8p12]  
Fusion : MitelmanFAM222B/UNC5D [17q11.2/8p12]  
Fusion : MitelmanIKBKB/UNC5D [8p11.21/8p12]  
Fusion : MitelmanPEBP4/UNC5D [8p21.3/8p12]  
Fusion : MitelmanPOLB/UNC5D [8p11.21/8p12]  
Fusion : MitelmanRAB11FIP1/UNC5D [8p11.23/8p12]  
Fusion : MitelmanTPX2/UNC5D [20q11.21/8p12]  
Fusion : MitelmanUNC5D/EIF4EBP1 [8p12/8p11.23]  
Fusion : QuiverUNC5D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUNC5D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UNC5D
dbVarUNC5D
ClinVarUNC5D
MonarchUNC5D
1000_GenomesUNC5D 
Exome Variant ServerUNC5D
GNOMAD BrowserENSG00000156687
Varsome BrowserUNC5D
ACMGUNC5D variants
VarityQ6UXZ4
Genomic Variants (DGV)UNC5D [DGVbeta]
DECIPHERUNC5D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUNC5D 
Mutations
ICGC Data PortalUNC5D 
TCGA Data PortalUNC5D 
Broad Tumor PortalUNC5D
OASIS PortalUNC5D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUNC5D  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUNC5D
Mutations and Diseases : HGMDUNC5D
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUNC5D
DgiDB (Drug Gene Interaction Database)UNC5D
DoCM (Curated mutations)UNC5D
CIViC (Clinical Interpretations of Variants in Cancer)UNC5D
Cancer3DUNC5D
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616466   
Orphanet
DisGeNETUNC5D
MedgenUNC5D
Genetic Testing Registry UNC5D
NextProtQ6UXZ4 [Medical]
GENETestsUNC5D
Target ValidationUNC5D
Huge Navigator UNC5D [HugePedia]
ClinGenUNC5D
Clinical trials, drugs, therapy
MyCancerGenomeUNC5D
Protein Interactions : CTDUNC5D
Pharm GKB GenePA38612
PharosQ6UXZ4
Clinical trialUNC5D
Miscellaneous
canSAR (ICR)UNC5D
HarmonizomeUNC5D
DataMed IndexUNC5D
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUNC5D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:37:29 CEST 2021

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