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UNG (uracil DNA glycosylase)

Identity

Other namesDGU
HIGM4
HIGM5
UDG
UNG1
UNG15
UNG2
HGNC (Hugo) UNG
LocusID (NCBI) 7374
Atlas_Id 42767
Location 12q24.11  [Link to chromosome band 12q24]
Location_base_pair Starts at 109535923 and ends at 109548798 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACACB (12q24.11) / UNG (12q24.11)ACACB 12q24.11 / UNG 12q24.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UNG   12572
Cards
Entrez_Gene (NCBI)UNG  7374  uracil DNA glycosylase
AliasesDGU; HIGM4; HIGM5; UDG; 
UNG1; UNG15; UNG2
GeneCards (Weizmann)UNG
Ensembl hg19 (Hinxton)ENSG00000076248 [Gene_View]  chr12:109535923-109548798 [Contig_View]  UNG [Vega]
Ensembl hg38 (Hinxton)ENSG00000076248 [Gene_View]  chr12:109535923-109548798 [Contig_View]  UNG [Vega]
ICGC DataPortalENSG00000076248
TCGA cBioPortalUNG
AceView (NCBI)UNG
Genatlas (Paris)UNG
WikiGenes7374
SOURCE (Princeton)UNG
Genomic and cartography
GoldenPath hg19 (UCSC)UNG  -     chr12:109535923-109548798 +  12q24.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UNG  -     12q24.11   [Description]    (hg38-Dec_2013)
EnsemblUNG - 12q24.11 [CytoView hg19]  UNG - 12q24.11 [CytoView hg38]
Mapping of homologs : NCBIUNG [Mapview hg19]  UNG [Mapview hg38]
OMIM191525   608106   
Gene and transcription
Genbank (Entrez)AK291341 AK299416 AK313552 BC015205 BC050634
RefSeq transcript (Entrez)NM_003362 NM_080911
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_007284 NT_029419 NW_004929385
Consensus coding sequences : CCDS (NCBI)UNG
Cluster EST : UnigeneHs.191334 [ NCBI ]
CGAP (NCI)Hs.191334
Alternative Splicing GalleryENSG00000076248
Gene ExpressionUNG [ NCBI-GEO ]   UNG [ EBI - ARRAY_EXPRESS ]   UNG [ SEEK ]   UNG [ MEM ]
Gene Expression Viewer (FireBrowse)UNG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7374
GTEX Portal (Tissue expression)UNG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13051 (Uniprot)
NextProtP13051  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13051
Splice isoforms : SwissVarP13051 (Swissvar)
PhosPhoSitePlusP13051
Domaine pattern : Prosite (Expaxy)U_DNA_GLYCOSYLASE (PS00130)   
Domains : Interpro (EBI)Ura-DNA_Glyclase_AS    Ura_DNA_glycsylse    Uracil-DNA_glycosylase-like   
Domain families : Pfam (Sanger)UDG (PF03167)   
Domain families : Pfam (NCBI)pfam03167   
Domain families : Smart (EMBL)UDG (SM00986)  
DMDM Disease mutations7374
Blocks (Seattle)UNG
PDB (SRS)1AKZ    1DPU    1EMH    1EMJ    1Q3F    1SSP    1UGH    1YUO    2HXM    2OXM    2OYT    2SSP    3FCF    3FCI    3FCK    3FCL    3TKB    4SKN   
PDB (PDBSum)1AKZ    1DPU    1EMH    1EMJ    1Q3F    1SSP    1UGH    1YUO    2HXM    2OXM    2OYT    2SSP    3FCF    3FCI    3FCK    3FCL    3TKB    4SKN   
PDB (IMB)1AKZ    1DPU    1EMH    1EMJ    1Q3F    1SSP    1UGH    1YUO    2HXM    2OXM    2OYT    2SSP    3FCF    3FCI    3FCK    3FCL    3TKB    4SKN   
PDB (RSDB)1AKZ    1DPU    1EMH    1EMJ    1Q3F    1SSP    1UGH    1YUO    2HXM    2OXM    2OYT    2SSP    3FCF    3FCI    3FCK    3FCL    3TKB    4SKN   
Structural Biology KnowledgeBase1AKZ    1DPU    1EMH    1EMJ    1Q3F    1SSP    1UGH    1YUO    2HXM    2OXM    2OYT    2SSP    3FCF    3FCI    3FCK    3FCL    3TKB    4SKN   
SCOP (Structural Classification of Proteins)1AKZ    1DPU    1EMH    1EMJ    1Q3F    1SSP    1UGH    1YUO    2HXM    2OXM    2OYT    2SSP    3FCF    3FCI    3FCK    3FCL    3TKB    4SKN   
CATH (Classification of proteins structures)1AKZ    1DPU    1EMH    1EMJ    1Q3F    1SSP    1UGH    1YUO    2HXM    2OXM    2OYT    2SSP    3FCF    3FCI    3FCK    3FCL    3TKB    4SKN   
SuperfamilyP13051
Human Protein AtlasENSG00000076248
Peptide AtlasP13051
HPRD01881
IPIIPI00011069   IPI00006516   IPI00909037   IPI01012179   IPI01010925   IPI01011729   
Protein Interaction databases
DIP (DOE-UCLA)P13051
IntAct (EBI)P13051
FunCoupENSG00000076248
BioGRIDUNG
STRING (EMBL)UNG
ZODIACUNG
Ontologies - Pathways
QuickGOP13051
Ontology : AmiGOdamaged DNA binding  uracil DNA N-glycosylase activity  uracil DNA N-glycosylase activity  protein binding  nucleus  nucleoplasm  mitochondrion  DNA repair  base-excision repair  viral process  somatic hypermutation of immunoglobulin genes  somatic recombination of immunoglobulin gene segments  enzyme binding  negative regulation of apoptotic process  depyrimidination  positive regulation of isotype switching  base-excision repair, AP site formation via deaminated base removal  
Ontology : EGO-EBIdamaged DNA binding  uracil DNA N-glycosylase activity  uracil DNA N-glycosylase activity  protein binding  nucleus  nucleoplasm  mitochondrion  DNA repair  base-excision repair  viral process  somatic hypermutation of immunoglobulin genes  somatic recombination of immunoglobulin gene segments  enzyme binding  negative regulation of apoptotic process  depyrimidination  positive regulation of isotype switching  base-excision repair, AP site formation via deaminated base removal  
Pathways : KEGGBase excision repair    Primary immunodeficiency   
NDEx Network
Atlas of Cancer Signalling NetworkUNG
Wikipedia pathwaysUNG
Orthology - Evolution
OrthoDB7374
GeneTree (enSembl)ENSG00000076248
Phylogenetic Trees/Animal Genes : TreeFamUNG
Homologs : HomoloGeneUNG
Homology/Alignments : Family Browser (UCSC)UNG
Gene fusions - Rearrangements
Fusion: TCGAACACB 12q24.11 UNG 12q24.11 BRCA SKCM
Polymorphisms : SNP, variants
NCBI Variation ViewerUNG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UNG
dbVarUNG
ClinVarUNG
1000_GenomesUNG 
Exome Variant ServerUNG
ExAC (Exome Aggregation Consortium)UNG (select the gene name)
Genetic variants : HAPMAP7374
Genomic Variants (DGV)UNG [DGVbeta]
Mutations
ICGC Data PortalUNG 
TCGA Data PortalUNG 
Broad Tumor PortalUNG
OASIS PortalUNG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUNG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch UNG
DgiDB (Drug Gene Interaction Database)UNG
DoCM (Curated mutations)UNG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UNG (select a term)
intoGenUNG
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:109535923-109548798  ENSG00000076248
CONAN: Copy Number AnalysisUNG 
Mutations and Diseases : HGMDUNG
OMIM191525    608106   
MedgenUNG
Genetic Testing Registry UNG
NextProtP13051 [Medical]
TSGene7374
GENETestsUNG
Huge Navigator UNG [HugePedia]
snp3D : Map Gene to Disease7374
BioCentury BCIQUNG
ClinGenUNG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7374
Chemical/Pharm GKB GenePA364
Clinical trialUNG
Miscellaneous
canSAR (ICR)UNG (select the gene name)
Probes
Litterature
PubMed153 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUNG
EVEXUNG
GoPubMedUNG
iHOPUNG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:11:09 CEST 2016

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