UNG (uracil DNA glycosylase)

2003-02-01  

Identity

HGNC
LOCATION
12q24.11
LOCUSID
ALIAS
DGU,HIGM4,HIGM5,UDG,UNG1,UNG15,UNG2
FUSION GENES

Other Information

Locus ID:

NCBI: 7374
MIM: 191525
HGNC: 12572
Ensembl: ENSG00000076248

Variants:

dbSNP: 7374
ClinVar: 7374
TCGA: ENSG00000076248
COSMIC: UNG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076248ENST00000242576P13051
ENSG00000076248ENST00000242576E5KTA5
ENSG00000076248ENST00000336865P13051
ENSG00000076248ENST00000336865E5KTA6
ENSG00000076248ENST00000446767Q68DM5
ENSG00000076248ENST00000539287F5GYA2

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Primary immunodeficiencyKEGGko05340
Base excision repairKEGGhsa03410
Primary immunodeficiencyKEGGhsa05340
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepyrimidinationREACTOMER-HSA-73928
Recognition and association of DNA glycosylase with site containing an affected pyrimidineREACTOMER-HSA-110328
Cleavage of the damaged pyrimidineREACTOMER-HSA-110329
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Displacement of DNA glycosylase by APEX1REACTOMER-HSA-110357

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129585962003Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.160
121614462002hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.109
173604882007HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.109
177047642007Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.92
172722832007Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA.71
208707152010HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.59
180796982008Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.58
201769602010Rotational dynamics of DNA on the nucleosome surface markedly impact accessibility to a DNA repair enzyme.41
153277772004The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair.40
175378172007Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.36

Citation

Dessen P

UNG (uracil DNA glycosylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42767/ung