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UNK (unkempt family zinc finger)

Identity

Alias_namesZC3HDC5
ZC3H5
zinc finger CCCH-type domain containing 5
zinc finger CCCH-type containing 5
unkempt homolog (Drosophila)
Alias_symbol (synonym)KIAA1753
Other aliasUNKEMPT
HGNC (Hugo) UNK
LocusID (NCBI) 85451
Atlas_Id 54756
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75784839 and ends at 75825805 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SERP1 (3q25.1) / UNK (17q25.1)TEN1 (17q25.1) / UNK (17q25.1)UNK (17q25.1) / AVIL (12q14.1)
UNK (17q25.1) / B4GALNT2 (17q21.32)UNK (17q25.1) / C17orf77 (17q25.1)UNK (17q25.1) / DPYD (1p21.3)
UNK (17q25.1) / FAM104A (17q25.1)UNK (17q25.1) / MYO15B (17q25.1)UNK (17q25.1) / NAF1 (4q32.2)
UNK (17q25.1) / PRKCA (17q24.2)UNK (17q25.1) / ZNF266 (19p13.2)UNK 17q25.1 / AVIL 12q14.1
UNK 17q25.1 / B4GALNT2 17q21.32UNK 17q25.1 / DPYD 1p21.3UNK 17q25.1 / NAF1 4q32.2
UNK 17q25.1 / PRKCA 17q24.2UNK 17q25.1 / ZNF266 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)UNK   29369
Cards
Entrez_Gene (NCBI)UNK  85451  unkempt family zinc finger
AliasesUNKEMPT; ZC3H5; ZC3HDC5
GeneCards (Weizmann)UNK
Ensembl hg19 (Hinxton)ENSG00000132478 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132478 [Gene_View]  chr17:75784839-75825805 [Contig_View]  UNK [Vega]
ICGC DataPortalENSG00000132478
TCGA cBioPortalUNK
AceView (NCBI)UNK
Genatlas (Paris)UNK
WikiGenes85451
SOURCE (Princeton)UNK
Genetics Home Reference (NIH)UNK
Genomic and cartography
GoldenPath hg38 (UCSC)UNK  -     chr17:75784839-75825805 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UNK  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblUNK - 17q25.1 [CytoView hg19]  UNK - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBIUNK [Mapview hg19]  UNK [Mapview hg38]
OMIM616375   
Gene and transcription
Genbank (Entrez)AB051540 AI290733 AK307289 BC033751 BC038802
RefSeq transcript (Entrez)NM_001080419
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UNK
Cluster EST : UnigeneHs.732048 [ NCBI ]
CGAP (NCI)Hs.732048
Alternative Splicing GalleryENSG00000132478
Gene ExpressionUNK [ NCBI-GEO ]   UNK [ EBI - ARRAY_EXPRESS ]   UNK [ SEEK ]   UNK [ MEM ]
Gene Expression Viewer (FireBrowse)UNK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85451
GTEX Portal (Tissue expression)UNK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0B0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C0B0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0B0
Splice isoforms : SwissVarQ9C0B0
PhosPhoSitePlusQ9C0B0
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Znf_CCCH   
Domain families : Pfam (Sanger)zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)UNK
DMDM Disease mutations85451
Blocks (Seattle)UNK
SuperfamilyQ9C0B0
Human Protein AtlasENSG00000132478
Peptide AtlasQ9C0B0
IPIIPI00028276   
Protein Interaction databases
DIP (DOE-UCLA)Q9C0B0
IntAct (EBI)Q9C0B0
FunCoupENSG00000132478
BioGRIDUNK
STRING (EMBL)UNK
ZODIACUNK
Ontologies - Pathways
QuickGOQ9C0B0
Ontology : AmiGOneuron migration  RNA binding  cytoplasm  polysome  metal ion binding  cell morphogenesis involved in neuron differentiation  mRNA CDS binding  negative regulation of cytoplasmic translation  
Ontology : EGO-EBIneuron migration  RNA binding  cytoplasm  polysome  metal ion binding  cell morphogenesis involved in neuron differentiation  mRNA CDS binding  negative regulation of cytoplasmic translation  
NDEx NetworkUNK
Atlas of Cancer Signalling NetworkUNK
Wikipedia pathwaysUNK
Orthology - Evolution
OrthoDB85451
GeneTree (enSembl)ENSG00000132478
Phylogenetic Trees/Animal Genes : TreeFamUNK
HOVERGENQ9C0B0
HOGENOMQ9C0B0
Homologs : HomoloGeneUNK
Homology/Alignments : Family Browser (UCSC)UNK
Gene fusions - Rearrangements
Fusion : MitelmanUNK/AVIL [17q25.1/12q14.1]  
Fusion : MitelmanUNK/B4GALNT2 [17q25.1/17q21.32]  [t(17;17)(q21;q25)]  
Fusion : MitelmanUNK/DPYD [17q25.1/1p21.3]  [t(1;17)(p21;q25)]  
Fusion : MitelmanUNK/MYO15B [17q25.1/17q25.1]  [dup(17)(q25q25)]  
Fusion : MitelmanUNK/NAF1 [17q25.1/4q32.2]  [t(4;17)(q32;q25)]  
Fusion : MitelmanUNK/PRKCA [17q25.1/17q24.2]  [t(17;17)(q24;q25)]  
Fusion : MitelmanUNK/ZNF266 [17q25.1/19p13.2]  [t(17;19)(q25;p13)]  
Fusion: TCGAUNK 17q25.1 AVIL 12q14.1 LUSC
Fusion: TCGAUNK 17q25.1 B4GALNT2 17q21.32 LUAD
Fusion: TCGAUNK 17q25.1 DPYD 1p21.3 LUSC
Fusion: TCGAUNK 17q25.1 NAF1 4q32.2 LUAD
Fusion: TCGAUNK 17q25.1 PRKCA 17q24.2 KIRC
Fusion: TCGAUNK 17q25.1 ZNF266 19p13.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUNK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UNK
dbVarUNK
ClinVarUNK
1000_GenomesUNK 
Exome Variant ServerUNK
ExAC (Exome Aggregation Consortium)UNK (select the gene name)
Genetic variants : HAPMAP85451
Genomic Variants (DGV)UNK [DGVbeta]
DECIPHERUNK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUNK 
Mutations
ICGC Data PortalUNK 
TCGA Data PortalUNK 
Broad Tumor PortalUNK
OASIS PortalUNK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUNK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUNK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UNK
DgiDB (Drug Gene Interaction Database)UNK
DoCM (Curated mutations)UNK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UNK (select a term)
intoGenUNK
Cancer3DUNK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616375   
Orphanet
MedgenUNK
Genetic Testing Registry UNK
NextProtQ9C0B0 [Medical]
TSGene85451
GENETestsUNK
Target ValidationUNK
Huge Navigator UNK [HugePedia]
snp3D : Map Gene to Disease85451
BioCentury BCIQUNK
ClinGenUNK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85451
Chemical/Pharm GKB GenePA162408651
Clinical trialUNK
Miscellaneous
canSAR (ICR)UNK (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUNK
EVEXUNK
GoPubMedUNK
iHOPUNK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:02:02 CEST 2017

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