UPP1 (uridine phosphorylase 1)

2007-02-01  

Identity

HGNC
LOCATION
7p12.3
LOCUSID
ALIAS
UDRPASE,UP,UPASE,UPP
FUSION GENES

Other Information

Locus ID:

NCBI: 7378
MIM: 191730
HGNC: 12576
Ensembl: ENSG00000183696

Variants:

dbSNP: 7378
ClinVar: 7378
TCGA: ENSG00000183696
COSMIC: UPP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183696ENST00000331803Q16831
ENSG00000183696ENST00000395560Q16831
ENSG00000183696ENST00000395564Q16831
ENSG00000183696ENST00000416681C9J486
ENSG00000183696ENST00000417464Q16831
ENSG00000183696ENST00000421046B4DND0
ENSG00000183696ENST00000432131C9K0J2
ENSG00000183696ENST00000436673C9JIP2
ENSG00000183696ENST00000444999F8WD51
ENSG00000183696ENST00000457596Q16831

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Drug metabolism - other enzymesKEGGko00983
Pyrimidine metabolismKEGGhsa00240
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine salvage reactionsREACTOMER-HSA-73614
Pyrimidine catabolismREACTOMER-HSA-73621

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120844552002Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update.30
192913082009Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy.9
118077892002Expression of uridine and thymidine phosphorylase genes in human breast carcinoma.7
167980572006The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.7
197143132009Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1.6
208568792010Active site conformational dynamics in human uridine phosphorylase 1.5
121153852002Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.3
281632442017Colonic transcriptional response to 1α,25(OH)2 vitamin D3 in African- and European-Americans.3

Citation

Dessen P

UPP1 (uridine phosphorylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45864/upp1