UPP1 (uridine phosphorylase 1)

2007-02-01  

Identity

HGNC
LOCATION
7p12.3
LOCUSID
ALIAS
UDRPASE,UP,UPASE,UPP
FUSION GENES

Other Information

Locus ID:

NCBI: 7378
MIM: 191730
HGNC: 12576
Ensembl: ENSG00000183696

Variants:

dbSNP: 7378
ClinVar: 7378
TCGA: ENSG00000183696
COSMIC: UPP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183696ENST00000331803Q16831
ENSG00000183696ENST00000395560Q16831
ENSG00000183696ENST00000395564Q16831
ENSG00000183696ENST00000416681C9J486
ENSG00000183696ENST00000417464Q16831
ENSG00000183696ENST00000421046B4DND0
ENSG00000183696ENST00000432131C9K0J2
ENSG00000183696ENST00000436673C9JIP2
ENSG00000183696ENST00000444999F8WD51
ENSG00000183696ENST00000457596Q16831

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Drug metabolism - other enzymesKEGGko00983
Pyrimidine metabolismKEGGhsa00240
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine salvage reactionsREACTOMER-HSA-73614
Pyrimidine catabolismREACTOMER-HSA-73621

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383318982024UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.1
387975192024Uridine phosphorylase-1 promotes cell viability and cell-cycle progression in human epidermal keratinocytes via the glycolytic pathway.0
383318982024UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.1
387975192024Uridine phosphorylase-1 promotes cell viability and cell-cycle progression in human epidermal keratinocytes via the glycolytic pathway.0
325835962020Uridine phosphorylase 1 is a novel immune-related target and predicts worse survival in brain glioma.19
328648392020Metabolites modulate the functional state of human uridine phosphorylase I.2
325835962020Uridine phosphorylase 1 is a novel immune-related target and predicts worse survival in brain glioma.19
328648392020Metabolites modulate the functional state of human uridine phosphorylase I.2
314960292019Uridine phosphorylase 1 associates to biological and clinical significance in thyroid carcinoma cell lines.13
314960292019Uridine phosphorylase 1 associates to biological and clinical significance in thyroid carcinoma cell lines.13
281632442017Colonic transcriptional response to 1α,25(OH)(2) vitamin D(3) in African- and European-Americans.11
281632442017Colonic transcriptional response to 1α,25(OH)(2) vitamin D(3) in African- and European-Americans.11
208568792010Active site conformational dynamics in human uridine phosphorylase 1.8
208568792010Active site conformational dynamics in human uridine phosphorylase 1.8
192913082009Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy.14

Citation

Dessen P

UPP1 (uridine phosphorylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45864/upp1