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UPP1 (uridine phosphorylase 1)

Identity

Alias_namesUP
uridine phosphorylase
Alias_symbol (synonym)UPASE
UPP
UDRPASE
Other alias
HGNC (Hugo) UPP1
LocusID (NCBI) 7378
Atlas_Id 45864
Location 7p12.3  [Link to chromosome band 7p12]
Location_base_pair Starts at 48088603 and ends at 48108733 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF4B (12q13.13) / UPP1 (7p12.3)SEPT14 (7p11.2) / UPP1 (7p12.3)UPP1 (7p12.3) / ESYT1 (12q13.2)
UPP1 (7p12.3) / UPP1 (7p12.3)SEPT14 7p11.2 / UPP1 7p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UPP1   12576
Cards
Entrez_Gene (NCBI)UPP1  7378  uridine phosphorylase 1
AliasesUDRPASE; UP; UPASE; UPP
GeneCards (Weizmann)UPP1
Ensembl hg19 (Hinxton)ENSG00000183696 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183696 [Gene_View]  chr7:48088603-48108733 [Contig_View]  UPP1 [Vega]
ICGC DataPortalENSG00000183696
TCGA cBioPortalUPP1
AceView (NCBI)UPP1
Genatlas (Paris)UPP1
WikiGenes7378
SOURCE (Princeton)UPP1
Genetics Home Reference (NIH)UPP1
Genomic and cartography
GoldenPath hg38 (UCSC)UPP1  -     chr7:48088603-48108733 +  7p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UPP1  -     7p12.3   [Description]    (hg19-Feb_2009)
EnsemblUPP1 - 7p12.3 [CytoView hg19]  UPP1 - 7p12.3 [CytoView hg38]
Mapping of homologs : NCBIUPP1 [Mapview hg19]  UPP1 [Mapview hg38]
OMIM191730   
Gene and transcription
Genbank (Entrez)AK096167 AK297863 BC001405 BC007348 BC047030
RefSeq transcript (Entrez)NM_001287426 NM_001287428 NM_001287429 NM_001287430 NM_003364 NM_181597
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UPP1
Cluster EST : UnigeneHs.488240 [ NCBI ]
CGAP (NCI)Hs.488240
Alternative Splicing GalleryENSG00000183696
Gene ExpressionUPP1 [ NCBI-GEO ]   UPP1 [ EBI - ARRAY_EXPRESS ]   UPP1 [ SEEK ]   UPP1 [ MEM ]
Gene Expression Viewer (FireBrowse)UPP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7378
GTEX Portal (Tissue expression)UPP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16831   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16831  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16831
Splice isoforms : SwissVarQ16831
PhosPhoSitePlusQ16831
Domaine pattern : Prosite (Expaxy)PNP_UDP_1 (PS01232)   
Domains : Interpro (EBI)Nucleoside_phosphorylase_CS    Nucleoside_phosphorylase_d    Uridine_phosphorylase_euk   
Domain families : Pfam (Sanger)PNP_UDP_1 (PF01048)   
Domain families : Pfam (NCBI)pfam01048   
Conserved Domain (NCBI)UPP1
DMDM Disease mutations7378
Blocks (Seattle)UPP1
PDB (SRS)3EUE    3EUF    3NBQ   
PDB (PDBSum)3EUE    3EUF    3NBQ   
PDB (IMB)3EUE    3EUF    3NBQ   
PDB (RSDB)3EUE    3EUF    3NBQ   
Structural Biology KnowledgeBase3EUE    3EUF    3NBQ   
SCOP (Structural Classification of Proteins)3EUE    3EUF    3NBQ   
CATH (Classification of proteins structures)3EUE    3EUF    3NBQ   
SuperfamilyQ16831
Human Protein AtlasENSG00000183696
Peptide AtlasQ16831
HPRD08932
IPIIPI00004406   IPI00220376   IPI01010160   IPI00924850   IPI00910040   IPI00925858   IPI00926240   IPI00926459   
Protein Interaction databases
DIP (DOE-UCLA)Q16831
IntAct (EBI)Q16831
FunCoupENSG00000183696
BioGRIDUPP1
STRING (EMBL)UPP1
ZODIACUPP1
Ontologies - Pathways
QuickGOQ16831
Ontology : AmiGOuridine phosphorylase activity  cytosol  nucleobase-containing compound metabolic process  uridine catabolic process  nucleotide catabolic process  cellular response to glucose starvation  pyrimidine nucleoside salvage  UMP salvage  pyrimidine nucleoside catabolic process  
Ontology : EGO-EBIuridine phosphorylase activity  cytosol  nucleobase-containing compound metabolic process  uridine catabolic process  nucleotide catabolic process  cellular response to glucose starvation  pyrimidine nucleoside salvage  UMP salvage  pyrimidine nucleoside catabolic process  
Pathways : KEGGPyrimidine metabolism    Drug metabolism - other enzymes   
NDEx NetworkUPP1
Atlas of Cancer Signalling NetworkUPP1
Wikipedia pathwaysUPP1
Orthology - Evolution
OrthoDB7378
GeneTree (enSembl)ENSG00000183696
Phylogenetic Trees/Animal Genes : TreeFamUPP1
HOVERGENQ16831
HOGENOMQ16831
Homologs : HomoloGeneUPP1
Homology/Alignments : Family Browser (UCSC)UPP1
Gene fusions - Rearrangements
Fusion : MitelmanSEPT14/UPP1 [7p11.2/7p12.3]  [t(7;7)(p11;p12)]  
Fusion: TCGASEPT14 7p11.2 UPP1 7p12.3 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUPP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UPP1
dbVarUPP1
ClinVarUPP1
1000_GenomesUPP1 
Exome Variant ServerUPP1
ExAC (Exome Aggregation Consortium)UPP1 (select the gene name)
Genetic variants : HAPMAP7378
Genomic Variants (DGV)UPP1 [DGVbeta]
DECIPHERUPP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUPP1 
Mutations
ICGC Data PortalUPP1 
TCGA Data PortalUPP1 
Broad Tumor PortalUPP1
OASIS PortalUPP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUPP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUPP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UPP1
DgiDB (Drug Gene Interaction Database)UPP1
DoCM (Curated mutations)UPP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UPP1 (select a term)
intoGenUPP1
Cancer3DUPP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191730   
Orphanet
MedgenUPP1
Genetic Testing Registry UPP1
NextProtQ16831 [Medical]
TSGene7378
GENETestsUPP1
Target ValidationUPP1
Huge Navigator UPP1 [HugePedia]
snp3D : Map Gene to Disease7378
BioCentury BCIQUPP1
ClinGenUPP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7378
Chemical/Pharm GKB GenePA365
Clinical trialUPP1
Miscellaneous
canSAR (ICR)UPP1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUPP1
EVEXUPP1
GoPubMedUPP1
iHOPUPP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:37:31 CEST 2017

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