UQCRB (ubiquinol-cytochrome c reductase binding protein)

2018-07-01  

Identity

HGNC
LOCATION
8q22.1
LOCUSID
ALIAS
MC3DN3,QCR7,QP-C,QPC,UQBC,UQBP,UQCR6,UQPC

Other Information

Locus ID:

NCBI: 7381
MIM: 191330
HGNC: 12582
Ensembl: ENSG00000156467

Variants:

dbSNP: 7381
ClinVar: 7381
TCGA: ENSG00000156467
COSMIC: UQCRB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156467ENST00000287022P14927
ENSG00000156467ENST00000517523E5RHG9
ENSG00000156467ENST00000517603E5RIT7
ENSG00000156467ENST00000518406P14927
ENSG00000156467ENST00000521036B7Z2R2
ENSG00000156467ENST00000523920B7Z2R2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Metabolic pathwaysKEGGhsa01100
Cytochrome bc1 complexKEGGhsa_M00152
Cytochrome bc1 complexKEGGM00152
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
225459192012Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer.9
254460852014A mutation in the mitochondrial protein UQCRB promotes angiogenesis through the generation of mitochondrial reactive oxygen species.7
291470092017Mitochondrial UQCRB as a new molecular prognostic biomarker of human colorectal cancer.6
234750742013Exploring the role of mitochondrial UQCRB in angiogenesis using small molecules.5
237089802013Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells.5
291154042018Downregulation of mitochondrial UQCRB inhibits cancer stem cell-like properties in glioblastoma.3
301203112018Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway.2
286049602017[Analysis of UQCRB gene mutation in a child with mitochondrial complex III deficiency].0

Citation

Dessen P

UQCRB (ubiquinol-cytochrome c reductase binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57528/uqcrb