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UQCRH (ubiquinol-cytochrome c reductase hinge protein)

Identity

Alias (NCBI)QCR6
UQCR8
HGNC (Hugo) UQCRH
HGNC Alias symbQCR6
UQCR8
HGNC Alias nameubiquinol-cytochrome c reductase, complex III subunit VIII
LocusID (NCBI) 7388
Atlas_Id 420
Location 1p33  [Link to chromosome band 1p33]
Location_base_pair Starts at 46303698 and ends at 46316775 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NSMAF (8q12.1) / UQCRH (1p34.1)UQCRH (1p34.1) / CLTA (9p13.3)UQCRH (1p34.1) / PIK3R3 (1p34.1)
UQCRH (1p34.1) / WASF1 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)UQCRH   12590
Cards
Entrez_Gene (NCBI)UQCRH    ubiquinol-cytochrome c reductase hinge protein
AliasesQCR6; UQCR8
GeneCards (Weizmann)UQCRH
Ensembl hg19 (Hinxton)ENSG00000173660 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173660 [Gene_View]  ENSG00000173660 [Sequence]  chr1:46303698-46316775 [Contig_View]  UQCRH [Vega]
ICGC DataPortalENSG00000173660
TCGA cBioPortalUQCRH
AceView (NCBI)UQCRH
Genatlas (Paris)UQCRH
SOURCE (Princeton)UQCRH
Genetics Home Reference (NIH)UQCRH
Genomic and cartography
GoldenPath hg38 (UCSC)UQCRH  -     chr1:46303698-46316775 +  1p33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UQCRH  -     1p33   [Description]    (hg19-Feb_2009)
GoldenPathUQCRH - 1p33 [CytoView hg19]  UQCRH - 1p33 [CytoView hg38]
ImmunoBaseENSG00000173660
Genome Data Viewer NCBIUQCRH [Mapview hg19]  
OMIM613844   
Gene and transcription
Genbank (Entrez)AA526171 AK311967 BC001426 BC001934 BC015177
RefSeq transcript (Entrez)NM_001297565 NM_001297566 NM_006004
Consensus coding sequences : CCDS (NCBI)UQCRH
Gene ExpressionUQCRH [ NCBI-GEO ]   UQCRH [ EBI - ARRAY_EXPRESS ]   UQCRH [ SEEK ]   UQCRH [ MEM ]
Gene Expression Viewer (FireBrowse)UQCRH [ Firebrowse - Broad ]
GenevisibleExpression of UQCRH in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7388
GTEX Portal (Tissue expression)UQCRH
Human Protein AtlasENSG00000173660-UQCRH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07919   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07919  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07919
PhosPhoSitePlusP07919
Domains : Interpro (EBI)Cyt_b-c1_6    Ubol_cytC_Rdtase_hinge_dom    Ubol_cytC_Rdtase_hinge_dom_sf   
Domain families : Pfam (Sanger)UCR_hinge (PF02320)   
Domain families : Pfam (NCBI)pfam02320   
Conserved Domain (NCBI)UQCRH
PDB (RSDB)5XTE    5XTH    5XTI   
PDB Europe5XTE    5XTH    5XTI   
PDB (PDBSum)5XTE    5XTH    5XTI   
PDB (IMB)5XTE    5XTH    5XTI   
Structural Biology KnowledgeBase5XTE    5XTH    5XTI   
SCOP (Structural Classification of Proteins)5XTE    5XTH    5XTI   
CATH (Classification of proteins structures)5XTE    5XTH    5XTI   
SuperfamilyP07919
AlphaFold pdb e-kbP07919   
Human Protein Atlas [tissue]ENSG00000173660-UQCRH [tissue]
HPRD15629
Protein Interaction databases
DIP (DOE-UCLA)P07919
IntAct (EBI)P07919
BioGRIDUQCRH
STRING (EMBL)UQCRH
ZODIACUQCRH
Ontologies - Pathways
QuickGOP07919
Ontology : AmiGOprotein binding  mitochondrion  mitochondrial inner membrane  mitochondrial respirasome  mitochondrial respiratory chain complex III  oxidative phosphorylation  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, ubiquinol to cytochrome c  ubiquinol-cytochrome-c reductase activity  aerobic respiration  
Ontology : EGO-EBIprotein binding  mitochondrion  mitochondrial inner membrane  mitochondrial respirasome  mitochondrial respiratory chain complex III  oxidative phosphorylation  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, ubiquinol to cytochrome c  ubiquinol-cytochrome-c reductase activity  aerobic respiration  
Pathways : KEGGOxidative phosphorylation    Cardiac muscle contraction    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkUQCRH
Atlas of Cancer Signalling NetworkUQCRH
Wikipedia pathwaysUQCRH
Orthology - Evolution
OrthoDB7388
GeneTree (enSembl)ENSG00000173660
Phylogenetic Trees/Animal Genes : TreeFamUQCRH
Homologs : HomoloGeneUQCRH
Homology/Alignments : Family Browser (UCSC)UQCRH
Gene fusions - Rearrangements
Fusion : QuiverUQCRH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUQCRH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UQCRH
dbVarUQCRH
ClinVarUQCRH
MonarchUQCRH
1000_GenomesUQCRH 
Exome Variant ServerUQCRH
GNOMAD BrowserENSG00000173660
Varsome BrowserUQCRH
ACMGUQCRH variants
VarityP07919
Genomic Variants (DGV)UQCRH [DGVbeta]
DECIPHERUQCRH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUQCRH 
Mutations
ICGC Data PortalUQCRH 
TCGA Data PortalUQCRH 
Broad Tumor PortalUQCRH
OASIS PortalUQCRH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUQCRH  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUQCRH
Mutations and Diseases : HGMDUQCRH
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUQCRH
DgiDB (Drug Gene Interaction Database)UQCRH
DoCM (Curated mutations)UQCRH
CIViC (Clinical Interpretations of Variants in Cancer)UQCRH
Cancer3DUQCRH
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613844   
Orphanet
DisGeNETUQCRH
MedgenUQCRH
Genetic Testing Registry UQCRH
NextProtP07919 [Medical]
GENETestsUQCRH
Target ValidationUQCRH
Huge Navigator UQCRH [HugePedia]
ClinGenUQCRH
Clinical trials, drugs, therapy
MyCancerGenomeUQCRH
Protein Interactions : CTDUQCRH
Pharm GKB GenePA37220
PharosP07919
Clinical trialUQCRH
Miscellaneous
canSAR (ICR)UQCRH
HarmonizomeUQCRH
DataMed IndexUQCRH
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUQCRH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:37:34 CEST 2021

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