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UQCRH (ubiquinol-cytochrome c reductase hinge protein)

Identity

Alias_namescomplex III subunit VIII
Alias_symbol (synonym)QCR6
UQCR8
Other alias
HGNC (Hugo) UQCRH
LocusID (NCBI) 7388
Atlas_Id 420
Location 1p33  [Link to chromosome band 1p33]
Location_base_pair Starts at 46303613 and ends at 46316777 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NSMAF (8q12.1) / UQCRH (1p34.1)UQCRH (1p34.1) / CLTA (9p13.3)UQCRH (1p34.1) / PIK3R3 (1p34.1)
UQCRH (1p34.1) / WASF1 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UQCRH   12590
Cards
Entrez_Gene (NCBI)UQCRH  7388  ubiquinol-cytochrome c reductase hinge protein
AliasesQCR6; UQCR8
GeneCards (Weizmann)UQCRH
Ensembl hg19 (Hinxton)ENSG00000173660 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173660 [Gene_View]  chr1:46303613-46316777 [Contig_View]  UQCRH [Vega]
ICGC DataPortalENSG00000173660
TCGA cBioPortalUQCRH
AceView (NCBI)UQCRH
Genatlas (Paris)UQCRH
WikiGenes7388
SOURCE (Princeton)UQCRH
Genetics Home Reference (NIH)UQCRH
Genomic and cartography
GoldenPath hg38 (UCSC)UQCRH  -     chr1:46303613-46316777 +  1p33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UQCRH  -     1p33   [Description]    (hg19-Feb_2009)
EnsemblUQCRH - 1p33 [CytoView hg19]  UQCRH - 1p33 [CytoView hg38]
Mapping of homologs : NCBIUQCRH [Mapview hg19]  UQCRH [Mapview hg38]
OMIM613844   
Gene and transcription
Genbank (Entrez)AA526171 AK311967 BC001426 BC001934 BC015177
RefSeq transcript (Entrez)NM_001297565 NM_001297566 NM_006004
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UQCRH
Cluster EST : UnigeneHs.481571 [ NCBI ]
CGAP (NCI)Hs.481571
Alternative Splicing GalleryENSG00000173660
Gene ExpressionUQCRH [ NCBI-GEO ]   UQCRH [ EBI - ARRAY_EXPRESS ]   UQCRH [ SEEK ]   UQCRH [ MEM ]
Gene Expression Viewer (FireBrowse)UQCRH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7388
GTEX Portal (Tissue expression)UQCRH
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07919   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07919  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07919
Splice isoforms : SwissVarP07919
PhosPhoSitePlusP07919
Domains : Interpro (EBI)Cyt_b-c1_6    Ubol_cytC_Rdtase_hinge_dom   
Domain families : Pfam (Sanger)UCR_hinge (PF02320)   
Domain families : Pfam (NCBI)pfam02320   
Conserved Domain (NCBI)UQCRH
DMDM Disease mutations7388
Blocks (Seattle)UQCRH
SuperfamilyP07919
Human Protein AtlasENSG00000173660
Peptide AtlasP07919
HPRD15629
IPIIPI00296022   IPI00872952   
Protein Interaction databases
DIP (DOE-UCLA)P07919
IntAct (EBI)P07919
FunCoupENSG00000173660
BioGRIDUQCRH
STRING (EMBL)UQCRH
ZODIACUQCRH
Ontologies - Pathways
QuickGOP07919
Ontology : AmiGOprotein binding  mitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain  mitochondrial respiratory chain complex III  oxidative phosphorylation  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, ubiquinol to cytochrome c  ubiquinol-cytochrome-c reductase activity  aerobic respiration  oxidation-reduction process  hydrogen ion transmembrane transport  
Ontology : EGO-EBIprotein binding  mitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain  mitochondrial respiratory chain complex III  oxidative phosphorylation  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, ubiquinol to cytochrome c  ubiquinol-cytochrome-c reductase activity  aerobic respiration  oxidation-reduction process  hydrogen ion transmembrane transport  
Pathways : KEGGOxidative phosphorylation    Cardiac muscle contraction    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkUQCRH
Atlas of Cancer Signalling NetworkUQCRH
Wikipedia pathwaysUQCRH
Orthology - Evolution
OrthoDB7388
GeneTree (enSembl)ENSG00000173660
Phylogenetic Trees/Animal Genes : TreeFamUQCRH
HOVERGENP07919
HOGENOMP07919
Homologs : HomoloGeneUQCRH
Homology/Alignments : Family Browser (UCSC)UQCRH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUQCRH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UQCRH
dbVarUQCRH
ClinVarUQCRH
1000_GenomesUQCRH 
Exome Variant ServerUQCRH
ExAC (Exome Aggregation Consortium)UQCRH (select the gene name)
Genetic variants : HAPMAP7388
Genomic Variants (DGV)UQCRH [DGVbeta]
DECIPHERUQCRH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUQCRH 
Mutations
ICGC Data PortalUQCRH 
TCGA Data PortalUQCRH 
Broad Tumor PortalUQCRH
OASIS PortalUQCRH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUQCRH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUQCRH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch UQCRH
DgiDB (Drug Gene Interaction Database)UQCRH
DoCM (Curated mutations)UQCRH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UQCRH (select a term)
intoGenUQCRH
Cancer3DUQCRH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613844   
Orphanet
MedgenUQCRH
Genetic Testing Registry UQCRH
NextProtP07919 [Medical]
TSGene7388
GENETestsUQCRH
Target ValidationUQCRH
Huge Navigator UQCRH [HugePedia]
snp3D : Map Gene to Disease7388
BioCentury BCIQUQCRH
ClinGenUQCRH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7388
Chemical/Pharm GKB GenePA37220
Clinical trialUQCRH
Miscellaneous
canSAR (ICR)UQCRH (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUQCRH
EVEXUQCRH
GoPubMedUQCRH
iHOPUQCRH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:05 CEST 2017

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