URGCP (upregulator of cell proliferation)

2007-02-01  

Identity

HGNC
LOCATION
7p13
LOCUSID
ALIAS
URG4
FUSION GENES

Other Information

Locus ID:

NCBI: 55665
MIM: 610337
HGNC: 30890
Ensembl: ENSG00000106608

Variants:

dbSNP: 55665
ClinVar: 55665
TCGA: ENSG00000106608
COSMIC: URGCP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106608ENST00000336086Q8TCY9
ENSG00000106608ENST00000402306Q8TCY9
ENSG00000106608ENST00000402306A0A024RA74
ENSG00000106608ENST00000426198C9JKA8
ENSG00000106608ENST00000439702F8WCC3
ENSG00000106608ENST00000443736Q8TCY9
ENSG00000106608ENST00000446958F8WDN0
ENSG00000106608ENST00000453200Q8TCY9
ENSG00000106608ENST00000455877C9J0W2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172176162006Enhanced cell survival of gastric cancer cells by a novel gene URG4.20
228157742012Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a.20
120825522002Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival.17
283156912017miR-519 suppresses nasopharyngeal carcinoma cell proliferation by targeting oncogene URG4/URGCP.11
189723162009The expression of novel gene URG4 in osteosarcoma: correlation with patients' prognosis.10
264298752015URGCP promotes non-small cell lung cancer invasiveness by activating the NF-κB-MMP-9 pathway.10
254279222014URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer.8
207149982010RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells.7
259476412015URG4/URGCP enhances the angiogenic capacity of human hepatocellular carcinoma cells in vitro via activation of the NF-κB signaling pathway.7
264298742015URGCP/URG4 promotes apoptotic resistance in bladder cancer cells by activating NF-κB signaling.7

Citation

Dessen P

URGCP (upregulator of cell proliferation)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45759/urgcp