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UROD (uroporphyrinogen decarboxylase)

Identity

Other aliasPCT
UPD
HGNC (Hugo) UROD
LocusID (NCBI) 7389
Atlas_Id 53982
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 45477805 and ends at 45481341 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HIPK1 (1p13.2) / UROD (1p34.1)LMO4 (1p22.3) / UROD (1p34.1)NSRP1 (17q11.2) / UROD (1p34.1)
UROD (1p34.1) / MCM3AP-AS1 (21q22.3)UROD (1p34.1) / UROD (1p34.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UROD   12591
LRG (Locus Reference Genomic)LRG_1079
Cards
Entrez_Gene (NCBI)UROD  7389  uroporphyrinogen decarboxylase
AliasesPCT; UPD
GeneCards (Weizmann)UROD
Ensembl hg19 (Hinxton)ENSG00000126088 [Gene_View]  chr1:45477805-45481341 [Contig_View]  UROD [Vega]
Ensembl hg38 (Hinxton)ENSG00000126088 [Gene_View]  chr1:45477805-45481341 [Contig_View]  UROD [Vega]
ICGC DataPortalENSG00000126088
TCGA cBioPortalUROD
AceView (NCBI)UROD
Genatlas (Paris)UROD
WikiGenes7389
SOURCE (Princeton)UROD
Genetics Home Reference (NIH)UROD
Genomic and cartography
GoldenPath hg19 (UCSC)UROD  -     chr1:45477805-45481341 +  1p34.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UROD  -     1p34.1   [Description]    (hg38-Dec_2013)
EnsemblUROD - 1p34.1 [CytoView hg19]  UROD - 1p34.1 [CytoView hg38]
Mapping of homologs : NCBIUROD [Mapview hg19]  UROD [Mapview hg38]
OMIM176100   613521   
Gene and transcription
Genbank (Entrez)AF104421 AF104422 AF104423 AF104424 AF104425
RefSeq transcript (Entrez)NM_000374
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_007122 NG_033058 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)UROD
Cluster EST : UnigeneHs.78601 [ NCBI ]
CGAP (NCI)Hs.78601
Alternative Splicing GalleryENSG00000126088
Gene ExpressionUROD [ NCBI-GEO ]   UROD [ EBI - ARRAY_EXPRESS ]   UROD [ SEEK ]   UROD [ MEM ]
Gene Expression Viewer (FireBrowse)UROD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7389
GTEX Portal (Tissue expression)UROD
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06132   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06132  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06132
Splice isoforms : SwissVarP06132
PhosPhoSitePlusP06132
Domaine pattern : Prosite (Expaxy)UROD_1 (PS00906)    UROD_2 (PS00907)   
Domains : Interpro (EBI)Uroporphyrinogen_deCO2ase_HemE    Uroporphyrinogen_deCOase   
Domain families : Pfam (Sanger)URO-D (PF01208)   
Domain families : Pfam (NCBI)pfam01208   
Conserved Domain (NCBI)UROD
DMDM Disease mutations7389
Blocks (Seattle)UROD
PDB (SRS)1JPH    1JPI    1JPK    1R3Q    1R3R    1R3S    1R3T    1R3V    1R3W    1R3Y    1URO    2Q6Z    2Q71    3GVQ    3GVR    3GVV    3GVW    3GW0    3GW3   
PDB (PDBSum)1JPH    1JPI    1JPK    1R3Q    1R3R    1R3S    1R3T    1R3V    1R3W    1R3Y    1URO    2Q6Z    2Q71    3GVQ    3GVR    3GVV    3GVW    3GW0    3GW3   
PDB (IMB)1JPH    1JPI    1JPK    1R3Q    1R3R    1R3S    1R3T    1R3V    1R3W    1R3Y    1URO    2Q6Z    2Q71    3GVQ    3GVR    3GVV    3GVW    3GW0    3GW3   
PDB (RSDB)1JPH    1JPI    1JPK    1R3Q    1R3R    1R3S    1R3T    1R3V    1R3W    1R3Y    1URO    2Q6Z    2Q71    3GVQ    3GVR    3GVV    3GVW    3GW0    3GW3   
Structural Biology KnowledgeBase1JPH    1JPI    1JPK    1R3Q    1R3R    1R3S    1R3T    1R3V    1R3W    1R3Y    1URO    2Q6Z    2Q71    3GVQ    3GVR    3GVV    3GVW    3GW0    3GW3   
SCOP (Structural Classification of Proteins)1JPH    1JPI    1JPK    1R3Q    1R3R    1R3S    1R3T    1R3V    1R3W    1R3Y    1URO    2Q6Z    2Q71    3GVQ    3GVR    3GVV    3GVW    3GW0    3GW3   
CATH (Classification of proteins structures)1JPH    1JPI    1JPK    1R3Q    1R3R    1R3S    1R3T    1R3V    1R3W    1R3Y    1URO    2Q6Z    2Q71    3GVQ    3GVR    3GVV    3GVW    3GW0    3GW3   
SuperfamilyP06132
Human Protein AtlasENSG00000126088
Peptide AtlasP06132
HPRD01441
IPIIPI00301489   IPI00909873   IPI00514944   IPI00514662   
Protein Interaction databases
DIP (DOE-UCLA)P06132
IntAct (EBI)P06132
FunCoupENSG00000126088
BioGRIDUROD
STRING (EMBL)UROD
ZODIACUROD
Ontologies - Pathways
QuickGOP06132
Ontology : AmiGOliver development  uroporphyrinogen decarboxylase activity  uroporphyrinogen decarboxylase activity  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  protoporphyrinogen IX biosynthetic process  heme biosynthetic process  heme biosynthetic process  heme biosynthetic process  ferrous iron binding  response to iron ion  response to amine  response to estradiol  response to ethanol  uroporphyrinogen III metabolic process  response to mercury ion  response to methylmercury  response to fungicide  cellular response to arsenic-containing substance  
Ontology : EGO-EBIliver development  uroporphyrinogen decarboxylase activity  uroporphyrinogen decarboxylase activity  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  protoporphyrinogen IX biosynthetic process  heme biosynthetic process  heme biosynthetic process  heme biosynthetic process  ferrous iron binding  response to iron ion  response to amine  response to estradiol  response to ethanol  uroporphyrinogen III metabolic process  response to mercury ion  response to methylmercury  response to fungicide  cellular response to arsenic-containing substance  
Pathways : BIOCARTAHemoglobin's Chaperone [Genes]   
Pathways : KEGGPorphyrin and chlorophyll metabolism   
NDEx NetworkUROD
Atlas of Cancer Signalling NetworkUROD
Wikipedia pathwaysUROD
Orthology - Evolution
OrthoDB7389
GeneTree (enSembl)ENSG00000126088
Phylogenetic Trees/Animal Genes : TreeFamUROD
HOVERGENP06132
HOGENOMP06132
Homologs : HomoloGeneUROD
Homology/Alignments : Family Browser (UCSC)UROD
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUROD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UROD
dbVarUROD
ClinVarUROD
1000_GenomesUROD 
Exome Variant ServerUROD
ExAC (Exome Aggregation Consortium)UROD (select the gene name)
Genetic variants : HAPMAP7389
Genomic Variants (DGV)UROD [DGVbeta]
DECIPHER (Syndromes)1:45477805-45481341  ENSG00000126088
CONAN: Copy Number AnalysisUROD 
Mutations
ICGC Data PortalUROD 
TCGA Data PortalUROD 
Broad Tumor PortalUROD
OASIS PortalUROD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUROD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUROD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UROD
DgiDB (Drug Gene Interaction Database)UROD
DoCM (Curated mutations)UROD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UROD (select a term)
intoGenUROD
Cancer3DUROD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176100    613521   
Orphanet23435    12580   
MedgenUROD
Genetic Testing Registry UROD
NextProtP06132 [Medical]
TSGene7389
GENETestsUROD
Huge Navigator UROD [HugePedia]
snp3D : Map Gene to Disease7389
BioCentury BCIQUROD
ClinGenUROD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7389
Chemical/Pharm GKB GenePA37221
Clinical trialUROD
Miscellaneous
canSAR (ICR)UROD (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUROD
EVEXUROD
GoPubMedUROD
iHOPUROD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:28 CEST 2017

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