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UROS (uroporphyrinogen III synthase)

Identity

Other aliasUROIIIS
HGNC (Hugo) UROS
LocusID (NCBI) 7390
Atlas_Id 75516
Location 10q26.2  [Link to chromosome band 10q26]
Location_base_pair Starts at 125788578 and ends at 125823268 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UROS   12592
LRG (Locus Reference Genomic)LRG_1081
Cards
Entrez_Gene (NCBI)UROS  7390  uroporphyrinogen III synthase
AliasesUROIIIS
GeneCards (Weizmann)UROS
Ensembl hg19 (Hinxton)ENSG00000188690 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188690 [Gene_View]  chr10:125788578-125823268 [Contig_View]  UROS [Vega]
ICGC DataPortalENSG00000188690
TCGA cBioPortalUROS
AceView (NCBI)UROS
Genatlas (Paris)UROS
WikiGenes7390
SOURCE (Princeton)UROS
Genetics Home Reference (NIH)UROS
Genomic and cartography
GoldenPath hg38 (UCSC)UROS  -     chr10:125788578-125823268 -  10q26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UROS  -     10q26.2   [Description]    (hg19-Feb_2009)
EnsemblUROS - 10q26.2 [CytoView hg19]  UROS - 10q26.2 [CytoView hg38]
Mapping of homologs : NCBIUROS [Mapview hg19]  UROS [Mapview hg38]
OMIM263700   606938   
Gene and transcription
Genbank (Entrez)AF230665 AK090736 AK092076 AK314896 BC002573
RefSeq transcript (Entrez)NM_000375 NM_001324036 NM_001324037 NM_001324038 NM_001324039
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UROS
Cluster EST : UnigeneHs.684451 [ NCBI ]
CGAP (NCI)Hs.684451
Alternative Splicing GalleryENSG00000188690
Gene ExpressionUROS [ NCBI-GEO ]   UROS [ EBI - ARRAY_EXPRESS ]   UROS [ SEEK ]   UROS [ MEM ]
Gene Expression Viewer (FireBrowse)UROS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7390
GTEX Portal (Tissue expression)UROS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10746   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10746  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10746
Splice isoforms : SwissVarP10746
Catalytic activity : Enzyme4.2.1.75 [ Enzyme-Expasy ]   4.2.1.754.2.1.75 [ IntEnz-EBI ]   4.2.1.75 [ BRENDA ]   4.2.1.75 [ KEGG ]   
PhosPhoSitePlusP10746
Domains : Interpro (EBI)4pyrrol_synth_uPrphyn_synth   
Domain families : Pfam (Sanger)HEM4 (PF02602)   
Domain families : Pfam (NCBI)pfam02602   
Conserved Domain (NCBI)UROS
DMDM Disease mutations7390
Blocks (Seattle)UROS
PDB (SRS)1JR2   
PDB (PDBSum)1JR2   
PDB (IMB)1JR2   
PDB (RSDB)1JR2   
Structural Biology KnowledgeBase1JR2   
SCOP (Structural Classification of Proteins)1JR2   
CATH (Classification of proteins structures)1JR2   
SuperfamilyP10746
Human Protein AtlasENSG00000188690
Peptide AtlasP10746
HPRD06087
IPIIPI00745889   IPI00745419   IPI00816053   IPI00646718   IPI00644175   
Protein Interaction databases
DIP (DOE-UCLA)P10746
IntAct (EBI)P10746
FunCoupENSG00000188690
BioGRIDUROS
STRING (EMBL)UROS
ZODIACUROS
Ontologies - Pathways
QuickGOP10746
Ontology : AmiGOuroporphyrinogen-III synthase activity  uroporphyrinogen-III synthase activity  mitochondrion  cytosol  cytosol  uroporphyrinogen III biosynthetic process  protoporphyrinogen IX biosynthetic process  heme biosynthetic process  heme biosynthetic process  heme biosynthetic process  response to antibiotic  cofactor binding  cellular response to arsenic-containing substance  cellular response to amine stimulus  
Ontology : EGO-EBIuroporphyrinogen-III synthase activity  uroporphyrinogen-III synthase activity  mitochondrion  cytosol  cytosol  uroporphyrinogen III biosynthetic process  protoporphyrinogen IX biosynthetic process  heme biosynthetic process  heme biosynthetic process  heme biosynthetic process  response to antibiotic  cofactor binding  cellular response to arsenic-containing substance  cellular response to amine stimulus  
Pathways : BIOCARTAHemoglobin's Chaperone [Genes]   
Pathways : KEGGPorphyrin and chlorophyll metabolism   
NDEx NetworkUROS
Atlas of Cancer Signalling NetworkUROS
Wikipedia pathwaysUROS
Orthology - Evolution
OrthoDB7390
GeneTree (enSembl)ENSG00000188690
Phylogenetic Trees/Animal Genes : TreeFamUROS
HOVERGENP10746
HOGENOMP10746
Homologs : HomoloGeneUROS
Homology/Alignments : Family Browser (UCSC)UROS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUROS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UROS
dbVarUROS
ClinVarUROS
1000_GenomesUROS 
Exome Variant ServerUROS
ExAC (Exome Aggregation Consortium)UROS (select the gene name)
Genetic variants : HAPMAP7390
Genomic Variants (DGV)UROS [DGVbeta]
DECIPHERUROS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUROS 
Mutations
ICGC Data PortalUROS 
TCGA Data PortalUROS 
Broad Tumor PortalUROS
OASIS PortalUROS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUROS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUROS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch UROS
DgiDB (Drug Gene Interaction Database)UROS
DoCM (Curated mutations)UROS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UROS (select a term)
intoGenUROS
Cancer3DUROS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM263700    606938   
Orphanet11303   
MedgenUROS
Genetic Testing Registry UROS
NextProtP10746 [Medical]
TSGene7390
GENETestsUROS
Huge Navigator UROS [HugePedia]
snp3D : Map Gene to Disease7390
BioCentury BCIQUROS
ClinGenUROS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7390
Chemical/Pharm GKB GenePA37222
Clinical trialUROS
Miscellaneous
canSAR (ICR)UROS (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUROS
EVEXUROS
GoPubMedUROS
iHOPUROS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:00:51 CEST 2017

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