USO1 (USO1 vesicle transport factor)

2014-07-01  

Identity

HGNC
LOCATION
4q21.1
LOCUSID
ALIAS
P115,TAP,VDP
FUSION GENES

Other Information

Locus ID:

NCBI: 8615
MIM: 603344
HGNC: 30904
Ensembl: ENSG00000138768

Variants:

dbSNP: 8615
ClinVar: 8615
TCGA: ENSG00000138768
COSMIC: USO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138768ENST00000264904O60763
ENSG00000138768ENST00000514213O60763
ENSG00000138768ENST00000514213A0A024RDG1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124384162002A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis.54
194546862009The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.51
147369162004Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis.47
172747992007The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.41
184345972008Coat-tether interaction in Golgi organization.41
202090572010Scyl1 regulates Golgi morphology.26
162569432005Depletion of vesicle-tethering factor p115 causes mini-stacked Golgi fragments with delayed protein transport.21
215366792011The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.14
190286832009Nuclear import is required for the pro-apoptotic function of the Golgi protein p115.13
192474792009Unusual armadillo fold in the human general vesicular transport factor p115.11

Citation

Dessen P

USO1 (USO1 vesicle transport factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54044/uso1