Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

USP10 (ubiquitin specific peptidase 10)

Identity

Alias (NCBI)UBPO
HGNC (Hugo) USP10
HGNC Alias symbUBPO
KIAA0190
HGNC Previous nameubiquitin specific protease 10
LocusID (NCBI) 9100
Atlas_Id 51378
Location 16q24.1  [Link to chromosome band 16q24]
Location_base_pair Starts at 84700000 and ends at 84779921 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGFR2 (10q26.13) / USP10 (16q24.1)GSE1 (16q24.1) / USP10 (16q24.1)TBCK (4q24) / USP10 (16q24.1)
USP10 (16q24.1) / ATP2C2 (16q24.1)USP10 (16q24.1) / COTL1 (16q24.1)USP10 (16q24.1) / CSNK2A2 (16q21)
USP10 (16q24.1) / NUP93 (16q13)USP10 (16q24.1) / SH3BP5 (3p25.1)USP10 (16q24.1) / USP10 (16q24.1)
USP10 (16q24.1) / ZDHHC7 (16q24.1)ZDHHC7 (16q24.1) / USP10 (16q24.1)FGFR2 10q26.13 / USP10 16q24.1
KIAA0182 USP10 16q24.1TBCK 4q24 / USP10 16q24.1ZDHHC7 16q24.1 / USP10 16q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;16)(q23;q24) KMT2A/USP10
dup(16)(q24q24) USP10/ATP2C2

External links

 

Nomenclature
HGNC (Hugo)USP10   12608
Cards
Entrez_Gene (NCBI)USP10    ubiquitin specific peptidase 10
AliasesUBPO
GeneCards (Weizmann)USP10
Ensembl hg19 (Hinxton)ENSG00000103194 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103194 [Gene_View]  ENSG00000103194 [Sequence]  chr16:84700000-84779921 [Contig_View]  USP10 [Vega]
ICGC DataPortalENSG00000103194
TCGA cBioPortalUSP10
AceView (NCBI)USP10
Genatlas (Paris)USP10
SOURCE (Princeton)USP10
Genetics Home Reference (NIH)USP10
Genomic and cartography
GoldenPath hg38 (UCSC)USP10  -     chr16:84700000-84779921 +  16q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP10  -     16q24.1   [Description]    (hg19-Feb_2009)
GoldenPathUSP10 - 16q24.1 [CytoView hg19]  USP10 - 16q24.1 [CytoView hg38]
ImmunoBaseENSG00000103194
Genome Data Viewer NCBIUSP10 [Mapview hg19]  
OMIM609818   
Gene and transcription
Genbank (Entrez)AK055375 AK293304 AK299618 AK315570 AL162049
RefSeq transcript (Entrez)NM_001272075 NM_005153
Consensus coding sequences : CCDS (NCBI)USP10
Gene ExpressionUSP10 [ NCBI-GEO ]   USP10 [ EBI - ARRAY_EXPRESS ]   USP10 [ SEEK ]   USP10 [ MEM ]
Gene Expression Viewer (FireBrowse)USP10 [ Firebrowse - Broad ]
GenevisibleExpression of USP10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9100
GTEX Portal (Tissue expression)USP10
Human Protein AtlasENSG00000103194-USP10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14694   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14694  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14694
PhosPhoSitePlusQ14694
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Ataxin-2_C    Papain-like_cys_pep_sf    Peptidase_C19_UCH    USP10    USP_CS    USP_dom   
Domain families : Pfam (Sanger)PAM2 (PF07145)    UCH (PF00443)   
Domain families : Pfam (NCBI)pfam07145    pfam00443   
Conserved Domain (NCBI)USP10
SuperfamilyQ14694
AlphaFold pdb e-kbQ14694   
Human Protein Atlas [tissue]ENSG00000103194-USP10 [tissue]
HPRD07029
Protein Interaction databases
DIP (DOE-UCLA)Q14694
IntAct (EBI)Q14694
BioGRIDUSP10
STRING (EMBL)USP10
ZODIACUSP10
Ontologies - Pathways
QuickGOQ14694
Ontology : AmiGOp53 binding  RNA binding  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  thiol-dependent deubiquitinase  thiol-dependent deubiquitinase  thiol-dependent deubiquitinase  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  early endosome  early endosome  cytosol  cytosol  cytosol  ubiquitin-dependent protein catabolic process  autophagy  cellular response to DNA damage stimulus  regulation of autophagy  regulation of autophagy  protein deubiquitination  protein deubiquitination  protein deubiquitination  protein deubiquitination  translesion synthesis  DNA damage response, signal transduction by p53 class mediator  DNA damage response, signal transduction by p53 class mediator  protein-containing complex  negative regulation of I-kappaB kinase/NF-kappaB signaling  ion channel binding  intermediate filament cytoskeleton  cellular response to interleukin-1  
Ontology : EGO-EBIp53 binding  RNA binding  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  thiol-dependent deubiquitinase  thiol-dependent deubiquitinase  thiol-dependent deubiquitinase  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  early endosome  early endosome  cytosol  cytosol  cytosol  ubiquitin-dependent protein catabolic process  autophagy  cellular response to DNA damage stimulus  regulation of autophagy  regulation of autophagy  protein deubiquitination  protein deubiquitination  protein deubiquitination  protein deubiquitination  translesion synthesis  DNA damage response, signal transduction by p53 class mediator  DNA damage response, signal transduction by p53 class mediator  protein-containing complex  negative regulation of I-kappaB kinase/NF-kappaB signaling  ion channel binding  intermediate filament cytoskeleton  cellular response to interleukin-1  
NDEx NetworkUSP10
Atlas of Cancer Signalling NetworkUSP10
Wikipedia pathwaysUSP10
Orthology - Evolution
OrthoDB9100
GeneTree (enSembl)ENSG00000103194
Phylogenetic Trees/Animal Genes : TreeFamUSP10
Homologs : HomoloGeneUSP10
Homology/Alignments : Family Browser (UCSC)USP10
Gene fusions - Rearrangements
Fusion : MitelmanFGFR2/USP10 [10q26.13/16q24.1]  
Fusion : MitelmanGSE1/USP10 [16q24.1/16q24.1]  
Fusion : MitelmanTBCK/USP10 [4q24/16q24.1]  
Fusion : MitelmanUSP10/ATP2C2 [16q24.1/16q24.1]  
Fusion : MitelmanUSP10/ZDHHC7 [16q24.1/16q24.1]  
Fusion : MitelmanZDHHC7/USP10 [16q24.1/16q24.1]  
Fusion : QuiverUSP10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP10
dbVarUSP10
ClinVarUSP10
MonarchUSP10
1000_GenomesUSP10 
Exome Variant ServerUSP10
GNOMAD BrowserENSG00000103194
Varsome BrowserUSP10
ACMGUSP10 variants
VarityQ14694
Genomic Variants (DGV)USP10 [DGVbeta]
DECIPHERUSP10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP10 
Mutations
ICGC Data PortalUSP10 
TCGA Data PortalUSP10 
Broad Tumor PortalUSP10
OASIS PortalUSP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUSP10
Mutations and Diseases : HGMDUSP10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaUSP10
DgiDB (Drug Gene Interaction Database)USP10
DoCM (Curated mutations)USP10
CIViC (Clinical Interpretations of Variants in Cancer)USP10
Cancer3DUSP10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609818   
Orphanet
DisGeNETUSP10
MedgenUSP10
Genetic Testing Registry USP10
NextProtQ14694 [Medical]
GENETestsUSP10
Target ValidationUSP10
Huge Navigator USP10 [HugePedia]
ClinGenUSP10
Clinical trials, drugs, therapy
MyCancerGenomeUSP10
Protein Interactions : CTDUSP10
Pharm GKB GenePA37234
PharosQ14694
Clinical trialUSP10
Miscellaneous
canSAR (ICR)USP10
HarmonizomeUSP10
DataMed IndexUSP10
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUSP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:37:35 CEST 2021
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.