Atlas of Genetics and Cytogenetics in Oncology and Haematology

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USP10 (ubiquitin specific peptidase 10)

Identity

Alias (NCBI)UBPO
HGNC (Hugo) USP10
HGNC Alias symbUBPO
KIAA0190
HGNC Previous nameubiquitin specific protease 10
LocusID (NCBI) 9100
Atlas_Id 51378
Location 16q24.1  [Link to chromosome band 16q24]
Location_base_pair Starts at 84700000 and ends at 84779921 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGFR2 (10q26.13) / USP10 (16q24.1)GSE1 (16q24.1) / USP10 (16q24.1)TBCK (4q24) / USP10 (16q24.1)
USP10 (16q24.1) / ATP2C2 (16q24.1)USP10 (16q24.1) / COTL1 (16q24.1)USP10 (16q24.1) / CSNK2A2 (16q21)
USP10 (16q24.1) / NUP93 (16q13)USP10 (16q24.1) / SH3BP5 (3p25.1)USP10 (16q24.1) / USP10 (16q24.1)
USP10 (16q24.1) / ZDHHC7 (16q24.1)ZDHHC7 (16q24.1) / USP10 (16q24.1)FGFR2 10q26.13 / USP10 16q24.1
KIAA0182 USP10 16q24.1TBCK 4q24 / USP10 16q24.1ZDHHC7 16q24.1 / USP10 16q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;16)(q23;q24) KMT2A/USP10
dup(16)(q24q24) USP10/ATP2C2

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  Prostate tumors: an overview
del(16)(q24q24) USP10/ZDHHC7
t(4;16)(q24;q24) TBCK/USP10
t(10;16)(q26;q24) FGFR2/USP10
GSE1/USP10 (16q24)
ZDHHC7/USP10 (16q24)

External links

Nomenclature
HGNC (Hugo)USP10   12608
Cards
Entrez_Gene (NCBI)USP10  9100  ubiquitin specific peptidase 10
AliasesUBPO
GeneCards (Weizmann)USP10
Ensembl hg19 (Hinxton)ENSG00000103194 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103194 [Gene_View]  ENSG00000103194 [Sequence]  chr16:84700000-84779921 [Contig_View]  USP10 [Vega]
ICGC DataPortalENSG00000103194
TCGA cBioPortalUSP10
AceView (NCBI)USP10
Genatlas (Paris)USP10
WikiGenes9100
SOURCE (Princeton)USP10
Genetics Home Reference (NIH)USP10
Genomic and cartography
GoldenPath hg38 (UCSC)USP10  -     chr16:84700000-84779921 +  16q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP10  -     16q24.1   [Description]    (hg19-Feb_2009)
GoldenPathUSP10 - 16q24.1 [CytoView hg19]  USP10 - 16q24.1 [CytoView hg38]
ImmunoBaseENSG00000103194
genome Data Viewer NCBIUSP10 [Mapview hg19]  
OMIM609818   
Gene and transcription
Genbank (Entrez)AK055375 AK293304 AK299618 AK315570 AL162049
RefSeq transcript (Entrez)NM_001272075 NM_005153
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP10
Alternative Splicing GalleryENSG00000103194
Gene ExpressionUSP10 [ NCBI-GEO ]   USP10 [ EBI - ARRAY_EXPRESS ]   USP10 [ SEEK ]   USP10 [ MEM ]
Gene Expression Viewer (FireBrowse)USP10 [ Firebrowse - Broad ]
GenevisibleExpression of USP10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9100
GTEX Portal (Tissue expression)USP10
Human Protein AtlasENSG00000103194-USP10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14694   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14694  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14694
Splice isoforms : SwissVarQ14694
PhosPhoSitePlusQ14694
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Ataxin-2_C    Papain-like_cys_pep_sf    Peptidase_C19_UCH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)PAM2 (PF07145)    UCH (PF00443)   
Domain families : Pfam (NCBI)pfam07145    pfam00443   
Conserved Domain (NCBI)USP10
DMDM Disease mutations9100
Blocks (Seattle)USP10
SuperfamilyQ14694
Human Protein Atlas [tissue]ENSG00000103194-USP10 [tissue]
Peptide AtlasQ14694
HPRD07029
IPIIPI00955965   IPI00941385   IPI00909971   IPI00470866   IPI00977122   IPI00291946   
Protein Interaction databases
DIP (DOE-UCLA)Q14694
IntAct (EBI)Q14694
FunCoupENSG00000103194
BioGRIDUSP10
STRING (EMBL)USP10
ZODIACUSP10
Ontologies - Pathways
QuickGOQ14694
Ontology : AmiGOp53 binding  RNA binding  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  early endosome  early endosome  cytosol  cytosol  cytosol  ubiquitin-dependent protein catabolic process  autophagy  cellular response to DNA damage stimulus  regulation of autophagy  regulation of autophagy  protein deubiquitination  protein deubiquitination  protein deubiquitination  protein deubiquitination  translesion synthesis  DNA damage response, signal transduction by p53 class mediator  DNA damage response, signal transduction by p53 class mediator  protein-containing complex  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  negative regulation of I-kappaB kinase/NF-kappaB signaling  ion channel binding  cellular response to interleukin-1  
Ontology : EGO-EBIp53 binding  RNA binding  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  early endosome  early endosome  cytosol  cytosol  cytosol  ubiquitin-dependent protein catabolic process  autophagy  cellular response to DNA damage stimulus  regulation of autophagy  regulation of autophagy  protein deubiquitination  protein deubiquitination  protein deubiquitination  protein deubiquitination  translesion synthesis  DNA damage response, signal transduction by p53 class mediator  DNA damage response, signal transduction by p53 class mediator  protein-containing complex  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  negative regulation of I-kappaB kinase/NF-kappaB signaling  ion channel binding  cellular response to interleukin-1  
NDEx NetworkUSP10
Atlas of Cancer Signalling NetworkUSP10
Wikipedia pathwaysUSP10
Orthology - Evolution
OrthoDB9100
GeneTree (enSembl)ENSG00000103194
Phylogenetic Trees/Animal Genes : TreeFamUSP10
HOGENOMQ14694
Homologs : HomoloGeneUSP10
Homology/Alignments : Family Browser (UCSC)USP10
Gene fusions - Rearrangements
Fusion : MitelmanFGFR2/USP10 [10q26.13/16q24.1]  
Fusion : MitelmanGSE1/USP10 [16q24.1/16q24.1]  
Fusion : MitelmanTBCK/USP10 [4q24/16q24.1]  
Fusion : MitelmanUSP10/ATP2C2 [16q24.1/16q24.1]  
Fusion : MitelmanUSP10/ZDHHC7 [16q24.1/16q24.1]  
Fusion : MitelmanZDHHC7/USP10 [16q24.1/16q24.1]  
Fusion PortalFGFR2 10q26.13 USP10 16q24.1 OV
Fusion PortalKIAA0182 USP10 16q24.1 LUAD
Fusion PortalTBCK 4q24 USP10 16q24.1 BRCA
Fusion PortalZDHHC7 16q24.1 USP10 16q24.1 SKCM
Fusion : QuiverUSP10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP10
dbVarUSP10
ClinVarUSP10
MonarchUSP10
1000_GenomesUSP10 
Exome Variant ServerUSP10
GNOMAD BrowserENSG00000103194
Varsome BrowserUSP10
Genetic variants : HAPMAP9100
Genomic Variants (DGV)USP10 [DGVbeta]
DECIPHERUSP10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP10 
Mutations
ICGC Data PortalUSP10 
TCGA Data PortalUSP10 
Broad Tumor PortalUSP10
OASIS PortalUSP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUSP10
Mutations and Diseases : HGMDUSP10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP10
DgiDB (Drug Gene Interaction Database)USP10
DoCM (Curated mutations)USP10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP10 (select a term)
intoGenUSP10
Cancer3DUSP10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609818   
Orphanet
DisGeNETUSP10
MedgenUSP10
Genetic Testing Registry USP10
NextProtQ14694 [Medical]
TSGene9100
GENETestsUSP10
Target ValidationUSP10
Huge Navigator USP10 [HugePedia]
snp3D : Map Gene to Disease9100
BioCentury BCIQUSP10
ClinGenUSP10
Clinical trials, drugs, therapy
Protein Interactions : CTD9100
Pharm GKB GenePA37234
Clinical trialUSP10
Miscellaneous
canSAR (ICR)USP10 (select the gene name)
HarmonizomeUSP10
DataMed IndexUSP10
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP10
EVEXUSP10
GoPubMedUSP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:38:21 CEST 2020
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