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USP13 (ubiquitin specific peptidase 13 (isopeptidase T-3))

Identity

Alias_namesubiquitin specific protease 13 (isopeptidase T-3)
Alias_symbol (synonym)IsoT-3
Other aliasISOT3
HGNC (Hugo) USP13
LocusID (NCBI) 8975
Atlas_Id 53713
Location 3q26.33  [Link to chromosome band 3q26]
Location_base_pair Starts at 179653145 and ends at 179789401 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EAPP (14q13.1) / USP13 (3q26.33)FXR1 (3q26.33) / USP13 (3q26.33)TBL1XR1 (3q26.32) / USP13 (3q26.33)
USP13 (3q26.33) / PIK3CA (3q26.32)USP13 (3q26.33) / RP5-862P8.2 ()USP13 (3q26.33) / USP13 (3q26.33)
EAPP 14q13.1 / USP13 3q26.33TBL1XR1 3q26.32 / USP13 3q26.33USP13 3q26.33 / PIK3CA 3q26.32
USP13 3q26.33 RP5-862P8.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP13   12611
Cards
Entrez_Gene (NCBI)USP13  8975  ubiquitin specific peptidase 13 (isopeptidase T-3)
AliasesISOT3; IsoT-3
GeneCards (Weizmann)USP13
Ensembl hg19 (Hinxton)ENSG00000058056 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000058056 [Gene_View]  chr3:179653145-179789401 [Contig_View]  USP13 [Vega]
ICGC DataPortalENSG00000058056
TCGA cBioPortalUSP13
AceView (NCBI)USP13
Genatlas (Paris)USP13
WikiGenes8975
SOURCE (Princeton)USP13
Genetics Home Reference (NIH)USP13
Genomic and cartography
GoldenPath hg38 (UCSC)USP13  -     chr3:179653145-179789401 +  3q26.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP13  -     3q26.33   [Description]    (hg19-Feb_2009)
EnsemblUSP13 - 3q26.33 [CytoView hg19]  USP13 - 3q26.33 [CytoView hg38]
Mapping of homologs : NCBIUSP13 [Mapview hg19]  USP13 [Mapview hg38]
OMIM603591   
Gene and transcription
Genbank (Entrez)AK091484 AK290338 AK302404 AM393315 AM393392
RefSeq transcript (Entrez)NM_003940
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP13
Cluster EST : UnigeneHs.175322 [ NCBI ]
CGAP (NCI)Hs.175322
Alternative Splicing GalleryENSG00000058056
Gene ExpressionUSP13 [ NCBI-GEO ]   USP13 [ EBI - ARRAY_EXPRESS ]   USP13 [ SEEK ]   USP13 [ MEM ]
Gene Expression Viewer (FireBrowse)USP13 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8975
GTEX Portal (Tissue expression)USP13
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92995   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92995  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92995
Splice isoforms : SwissVarQ92995
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ92995
Domaine pattern : Prosite (Expaxy)UBA (PS50030)    USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)    ZF_UBP (PS50271)   
Domains : Interpro (EBI)Peptidase_C19_UCH    UBA    UBA-like    Ubiquitinyl_hydrolase    USP_CS    USP_dom    Znf_RING/FYVE/PHD    Znf_UBP   
Domain families : Pfam (Sanger)UBA (PF00627)    UCH (PF00443)    zf-UBP (PF02148)   
Domain families : Pfam (NCBI)pfam00627    pfam00443    pfam02148   
Domain families : Smart (EMBL)UBA (SM00165)  ZnF_UBP (SM00290)  
Conserved Domain (NCBI)USP13
DMDM Disease mutations8975
Blocks (Seattle)USP13
PDB (SRS)2L80    2LBC   
PDB (PDBSum)2L80    2LBC   
PDB (IMB)2L80    2LBC   
PDB (RSDB)2L80    2LBC   
Structural Biology KnowledgeBase2L80    2LBC   
SCOP (Structural Classification of Proteins)2L80    2LBC   
CATH (Classification of proteins structures)2L80    2LBC   
SuperfamilyQ92995
Human Protein AtlasENSG00000058056
Peptide AtlasQ92995
HPRD04666
IPIIPI00024401   IPI00947195   IPI00796577   IPI00946465   
Protein Interaction databases
DIP (DOE-UCLA)Q92995
IntAct (EBI)Q92995
FunCoupENSG00000058056
BioGRIDUSP13
STRING (EMBL)USP13
ZODIACUSP13
Ontologies - Pathways
QuickGOQ92995
Ontology : AmiGOcysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  cytosol  regulation of transcription, DNA-templated  ubiquitin-dependent protein catabolic process  autophagy  zinc ion binding  cell proliferation  regulation of autophagy  protein deubiquitination  melanocyte differentiation  ubiquitin protein ligase binding  protein K29-linked deubiquitination  thiol-dependent ubiquitinyl hydrolase activity  ubiquitin binding  protein K6-linked deubiquitination  ubiquitin-like protein ligase binding  protein stabilization  protein stabilization  chaperone binding  protein K63-linked deubiquitination  proteasome binding  BAT3 complex binding  positive regulation of ERAD pathway  maintenance of unfolded protein involved in ERAD pathway  ubiquitin-specific protease activity involved in positive regulation of ERAD pathway  
Ontology : EGO-EBIcysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  cytosol  regulation of transcription, DNA-templated  ubiquitin-dependent protein catabolic process  autophagy  zinc ion binding  cell proliferation  regulation of autophagy  protein deubiquitination  melanocyte differentiation  ubiquitin protein ligase binding  protein K29-linked deubiquitination  thiol-dependent ubiquitinyl hydrolase activity  ubiquitin binding  protein K6-linked deubiquitination  ubiquitin-like protein ligase binding  protein stabilization  protein stabilization  chaperone binding  protein K63-linked deubiquitination  proteasome binding  BAT3 complex binding  positive regulation of ERAD pathway  maintenance of unfolded protein involved in ERAD pathway  ubiquitin-specific protease activity involved in positive regulation of ERAD pathway  
NDEx NetworkUSP13
Atlas of Cancer Signalling NetworkUSP13
Wikipedia pathwaysUSP13
Orthology - Evolution
OrthoDB8975
GeneTree (enSembl)ENSG00000058056
Phylogenetic Trees/Animal Genes : TreeFamUSP13
HOVERGENQ92995
HOGENOMQ92995
Homologs : HomoloGeneUSP13
Homology/Alignments : Family Browser (UCSC)USP13
Gene fusions - Rearrangements
Fusion : MitelmanEAPP/USP13 [14q13.1/3q26.33]  [t(3;14)(q26;q13)]  
Fusion : MitelmanTBL1XR1/USP13 [3q26.32/3q26.33]  [t(3;3)(q26;q26)]  
Fusion : MitelmanUSP13/PIK3CA [3q26.33/3q26.32]  [t(3;3)(q26;q26)]  
Fusion: TCGAEAPP 14q13.1 USP13 3q26.33 HNSC
Fusion: TCGATBL1XR1 3q26.32 USP13 3q26.33 BRCA
Fusion: TCGAUSP13 3q26.33 PIK3CA 3q26.32 BRCA
Fusion: TCGAUSP13 3q26.33 RP5-862P8.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP13
dbVarUSP13
ClinVarUSP13
1000_GenomesUSP13 
Exome Variant ServerUSP13
ExAC (Exome Aggregation Consortium)USP13 (select the gene name)
Genetic variants : HAPMAP8975
Genomic Variants (DGV)USP13 [DGVbeta]
DECIPHERUSP13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP13 
Mutations
ICGC Data PortalUSP13 
TCGA Data PortalUSP13 
Broad Tumor PortalUSP13
OASIS PortalUSP13 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP13  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP13
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP13
DgiDB (Drug Gene Interaction Database)USP13
DoCM (Curated mutations)USP13 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP13 (select a term)
intoGenUSP13
Cancer3DUSP13(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603591   
Orphanet
MedgenUSP13
Genetic Testing Registry USP13
NextProtQ92995 [Medical]
TSGene8975
GENETestsUSP13
Target ValidationUSP13
Huge Navigator USP13 [HugePedia]
snp3D : Map Gene to Disease8975
BioCentury BCIQUSP13
ClinGenUSP13
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8975
Chemical/Pharm GKB GenePA37237
Clinical trialUSP13
Miscellaneous
canSAR (ICR)USP13 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP13
EVEXUSP13
GoPubMedUSP13
iHOPUSP13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:08 CEST 2017

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