USP13 (ubiquitin specific peptidase 13)

2014-02-01  

Identity

HGNC
USP13
LOCATION
3q26.33
LOCUSID
8975
ALIAS
ISOT3,IsoT-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8975
MIM: 603591
HGNC: 12611
Ensembl: ENSG00000058056

Variants:

dbSNP: 8975
ClinVar: 8975
TCGA: ENSG00000058056
COSMIC: USP13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058056ENST00000263966Q92995
ENSG00000058056ENST00000263966A0A0A6YZ17
ENSG00000058056ENST00000496897Q92995
ENSG00000058056ENST00000497155H7C5J3
ENSG00000058056ENST00000497380H7C502

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
219625182011Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.250
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
242708912013Deubiquitylation and stabilization of PTEN by USP13.53
279239072017Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination.27
218112432011Regulation of MITF stability by the USP13 deubiquitinase.26
244244102014USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.23
216595122011USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains.21
239402782013Ubiquitin-specific protease 13 regulates IFN signaling by stabilizing STAT1.19
285698382017USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response.18
293354372018Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors.16

Citation

Dessen P

USP13 (ubiquitin specific peptidase 13)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53713/usp13