USP14 (ubiquitin specific peptidase 14)

2007-02-01  

Identity

HGNC
USP14
LOCATION
18p11.32
LOCUSID
9097
ALIAS
TGT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9097
MIM: 607274
HGNC: 12612
Ensembl: ENSG00000101557

Variants:

dbSNP: 9097
ClinVar: 9097
TCGA: ENSG00000101557
COSMIC: USP14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101557ENST00000261601P54578
ENSG00000101557ENST00000383589A6NJA2
ENSG00000101557ENST00000400266P54578
ENSG00000101557ENST00000580410J3QQT6
ENSG00000101557ENST00000581983J3KS55
ENSG00000101557ENST00000582707P54578
ENSG00000101557ENST00000583119R4GNB0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
162110102005Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.165
243192542014A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.113
197266492009The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions.54
270745032016USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites.54
170796712006Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14.37
275428282016USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1.35
281514782017Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor.34
265233942015Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system.32
164654092006Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases.30
237028452013Over-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-catenin.28

Citation

Dessen P

USP14 (ubiquitin specific peptidase 14)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43975/usp14