Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

USP14 (ubiquitin specific peptidase 14)

Identity

Alias_namesubiquitin specific protease 14 (tRNA-guanine transglycosylase)
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Alias_symbol (synonym)TGT
Other alias
HGNC (Hugo) USP14
LocusID (NCBI) 9097
Atlas_Id 43975
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 158483 and ends at 213739 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK19 (6q21) / USP14 (18p11.32)USP14 (18p11.32) / CHGA (14q32.12)USP14 (18p11.32) / CREG2 (2q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP14   12612
Cards
Entrez_Gene (NCBI)USP14  9097  ubiquitin specific peptidase 14
AliasesTGT
GeneCards (Weizmann)USP14
Ensembl hg19 (Hinxton)ENSG00000101557 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101557 [Gene_View]  chr18:158483-213739 [Contig_View]  USP14 [Vega]
ICGC DataPortalENSG00000101557
TCGA cBioPortalUSP14
AceView (NCBI)USP14
Genatlas (Paris)USP14
WikiGenes9097
SOURCE (Princeton)USP14
Genetics Home Reference (NIH)USP14
Genomic and cartography
GoldenPath hg38 (UCSC)USP14  -     chr18:158483-213739 +  18p11.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP14  -     18p11.32   [Description]    (hg19-Feb_2009)
EnsemblUSP14 - 18p11.32 [CytoView hg19]  USP14 - 18p11.32 [CytoView hg38]
Mapping of homologs : NCBIUSP14 [Mapview hg19]  USP14 [Mapview hg38]
OMIM607274   
Gene and transcription
Genbank (Entrez)AK095516 AK098497 AK297605 AK315438 BC003556
RefSeq transcript (Entrez)NM_001037334 NM_005151
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP14
Cluster EST : UnigeneHs.707058 [ NCBI ]
CGAP (NCI)Hs.707058
Alternative Splicing GalleryENSG00000101557
Gene ExpressionUSP14 [ NCBI-GEO ]   USP14 [ EBI - ARRAY_EXPRESS ]   USP14 [ SEEK ]   USP14 [ MEM ]
Gene Expression Viewer (FireBrowse)USP14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9097
GTEX Portal (Tissue expression)USP14
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54578   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54578  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54578
Splice isoforms : SwissVarP54578
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusP54578
Domaine pattern : Prosite (Expaxy)UBIQUITIN_1 (PS00299)    UBIQUITIN_2 (PS50053)    USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    Ubiquitin-rel_dom    Ubiquitin_CS    Ubiquitin_dom    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)USP14
DMDM Disease mutations9097
Blocks (Seattle)USP14
PDB (SRS)2AYN    2AYO    5GJQ   
PDB (PDBSum)2AYN    2AYO    5GJQ   
PDB (IMB)2AYN    2AYO    5GJQ   
PDB (RSDB)2AYN    2AYO    5GJQ   
Structural Biology KnowledgeBase2AYN    2AYO    5GJQ   
SCOP (Structural Classification of Proteins)2AYN    2AYO    5GJQ   
CATH (Classification of proteins structures)2AYN    2AYO    5GJQ   
SuperfamilyP54578
Human Protein AtlasENSG00000101557
Peptide AtlasP54578
HPRD06279
IPIIPI00219913   IPI00872664   IPI00640357   
Protein Interaction databases
DIP (DOE-UCLA)P54578
IntAct (EBI)P54578
FunCoupENSG00000101557
BioGRIDUSP14
STRING (EMBL)USP14
ZODIACUSP14
Ontologies - Pathways
QuickGOP54578
Ontology : AmiGOproteasome complex  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  endopeptidase inhibitor activity  protein binding  cytosol  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  chemical synaptic transmission  tRNA guanylyltransferase activity  cell surface  negative regulation of endopeptidase activity  protein deubiquitination  protein deubiquitination  cytoplasmic vesicle  synapse  regulation of chemotaxis  regulation of proteasomal protein catabolic process  extracellular exosome  proteasome binding  negative regulation of ER-associated ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIproteasome complex  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  endopeptidase inhibitor activity  protein binding  cytosol  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  chemical synaptic transmission  tRNA guanylyltransferase activity  cell surface  negative regulation of endopeptidase activity  protein deubiquitination  protein deubiquitination  cytoplasmic vesicle  synapse  regulation of chemotaxis  regulation of proteasomal protein catabolic process  extracellular exosome  proteasome binding  negative regulation of ER-associated ubiquitin-dependent protein catabolic process  
NDEx NetworkUSP14
Atlas of Cancer Signalling NetworkUSP14
Wikipedia pathwaysUSP14
Orthology - Evolution
OrthoDB9097
GeneTree (enSembl)ENSG00000101557
Phylogenetic Trees/Animal Genes : TreeFamUSP14
HOVERGENP54578
HOGENOMP54578
Homologs : HomoloGeneUSP14
Homology/Alignments : Family Browser (UCSC)USP14
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP14
dbVarUSP14
ClinVarUSP14
1000_GenomesUSP14 
Exome Variant ServerUSP14
ExAC (Exome Aggregation Consortium)USP14 (select the gene name)
Genetic variants : HAPMAP9097
Genomic Variants (DGV)USP14 [DGVbeta]
DECIPHERUSP14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP14 
Mutations
ICGC Data PortalUSP14 
TCGA Data PortalUSP14 
Broad Tumor PortalUSP14
OASIS PortalUSP14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP14
DgiDB (Drug Gene Interaction Database)USP14
DoCM (Curated mutations)USP14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP14 (select a term)
intoGenUSP14
Cancer3DUSP14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607274   
Orphanet
MedgenUSP14
Genetic Testing Registry USP14
NextProtP54578 [Medical]
TSGene9097
GENETestsUSP14
Target ValidationUSP14
Huge Navigator USP14 [HugePedia]
snp3D : Map Gene to Disease9097
BioCentury BCIQUSP14
ClinGenUSP14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9097
Chemical/Pharm GKB GenePA37238
Clinical trialUSP14
Miscellaneous
canSAR (ICR)USP14 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP14
EVEXUSP14
GoPubMedUSP14
iHOPUSP14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:02:08 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.