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USP16 (ubiquitin specific peptidase 16)

Identity

Alias_namesubiquitin specific protease 16
Alias_symbol (synonym)Ubp-M
Other aliasUBP-M
UBPM
HGNC (Hugo) USP16
LocusID (NCBI) 10600
Atlas_Id 51008
Location 21q21.3  [Link to chromosome band 21q21]
Location_base_pair Starts at 29024617 and ends at 29054486 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
USP16 (21q21.3) / CNBD2 (20q11.23)USP16 (21q21.3) / HOXA10-HOXA9 (7p15.2)USP16 (21q21.3) / PRDX1 (1p34.1)
USP16 (21q21.3) / RUNX1 (21q22.12)USP16 (21q21.3) / USP16 (21q21.3)USP16 21q21.3 C20orf152

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(21)(q21q22) USP16/RUNX1


External links

Nomenclature
HGNC (Hugo)USP16   12614
Cards
Entrez_Gene (NCBI)USP16  10600  ubiquitin specific peptidase 16
AliasesUBP-M; UBPM
GeneCards (Weizmann)USP16
Ensembl hg19 (Hinxton)ENSG00000156256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156256 [Gene_View]  chr21:29024617-29054486 [Contig_View]  USP16 [Vega]
ICGC DataPortalENSG00000156256
TCGA cBioPortalUSP16
AceView (NCBI)USP16
Genatlas (Paris)USP16
WikiGenes10600
SOURCE (Princeton)USP16
Genetics Home Reference (NIH)USP16
Genomic and cartography
GoldenPath hg38 (UCSC)USP16  -     chr21:29024617-29054486 +  21q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP16  -     21q21.3   [Description]    (hg19-Feb_2009)
EnsemblUSP16 - 21q21.3 [CytoView hg19]  USP16 - 21q21.3 [CytoView hg38]
Mapping of homologs : NCBIUSP16 [Mapview hg19]  USP16 [Mapview hg38]
OMIM604735   
Gene and transcription
Genbank (Entrez)AF113219 AF126736 AK023247 AK025104 AK025989
RefSeq transcript (Entrez)NM_001001992 NM_001032410 NM_006447
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP16
Cluster EST : UnigeneHs.99819 [ NCBI ]
CGAP (NCI)Hs.99819
Alternative Splicing GalleryENSG00000156256
Gene ExpressionUSP16 [ NCBI-GEO ]   USP16 [ EBI - ARRAY_EXPRESS ]   USP16 [ SEEK ]   USP16 [ MEM ]
Gene Expression Viewer (FireBrowse)USP16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10600
GTEX Portal (Tissue expression)USP16
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5T5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5T5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5T5
Splice isoforms : SwissVarQ9Y5T5
PhosPhoSitePlusQ9Y5T5
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)    ZF_UBP (PS50271)   
Domains : Interpro (EBI)Peptidase_C19_UCH    UBP16    USP_CS    USP_dom    Znf_RING/FYVE/PHD    Znf_UBP   
Domain families : Pfam (Sanger)UCH (PF00443)    zf-UBP (PF02148)   
Domain families : Pfam (NCBI)pfam00443    pfam02148   
Domain families : Smart (EMBL)ZnF_UBP (SM00290)  
Conserved Domain (NCBI)USP16
DMDM Disease mutations10600
Blocks (Seattle)USP16
PDB (SRS)2I50   
PDB (PDBSum)2I50   
PDB (IMB)2I50   
PDB (RSDB)2I50   
Structural Biology KnowledgeBase2I50   
SCOP (Structural Classification of Proteins)2I50   
CATH (Classification of proteins structures)2I50   
SuperfamilyQ9Y5T5
Human Protein AtlasENSG00000156256
Peptide AtlasQ9Y5T5
HPRD06881
IPIIPI00001780   IPI00428464   IPI00923398   IPI00923450   IPI00792644   IPI01010033   IPI00979008   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5T5
IntAct (EBI)Q9Y5T5
FunCoupENSG00000156256
BioGRIDUSP16
STRING (EMBL)USP16
ZODIACUSP16
Ontologies - Pathways
QuickGOQ9Y5T5
Ontology : AmiGOmitotic cell cycle  transcription coactivator activity  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  cell cycle  zinc ion binding  histone deubiquitination  protein deubiquitination  monoubiquitinated histone H2A deubiquitination  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  histone binding  ubiquitin binding  positive regulation of transcription, DNA-templated  positive regulation of translational elongation  positive regulation of transcription from RNA polymerase II promoter  protein homotetramerization  cell division  regulation of cell cycle  histone H2A K63-linked deubiquitination  
Ontology : EGO-EBImitotic cell cycle  transcription coactivator activity  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  cell cycle  zinc ion binding  histone deubiquitination  protein deubiquitination  monoubiquitinated histone H2A deubiquitination  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  histone binding  ubiquitin binding  positive regulation of transcription, DNA-templated  positive regulation of translational elongation  positive regulation of transcription from RNA polymerase II promoter  protein homotetramerization  cell division  regulation of cell cycle  histone H2A K63-linked deubiquitination  
NDEx NetworkUSP16
Atlas of Cancer Signalling NetworkUSP16
Wikipedia pathwaysUSP16
Orthology - Evolution
OrthoDB10600
GeneTree (enSembl)ENSG00000156256
Phylogenetic Trees/Animal Genes : TreeFamUSP16
HOVERGENQ9Y5T5
HOGENOMQ9Y5T5
Homologs : HomoloGeneUSP16
Homology/Alignments : Family Browser (UCSC)USP16
Gene fusions - Rearrangements
Fusion : MitelmanUSP16/CNBD2 [21q21.3/20q11.23]  
Fusion : MitelmanUSP16/RUNX1 [21q21.3/21q22.12]  [del(21)(q21q22)]  
Fusion: TCGAUSP16 21q21.3 C20orf152 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP16
dbVarUSP16
ClinVarUSP16
1000_GenomesUSP16 
Exome Variant ServerUSP16
ExAC (Exome Aggregation Consortium)USP16 (select the gene name)
Genetic variants : HAPMAP10600
Genomic Variants (DGV)USP16 [DGVbeta]
DECIPHERUSP16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP16 
Mutations
ICGC Data PortalUSP16 
TCGA Data PortalUSP16 
Broad Tumor PortalUSP16
OASIS PortalUSP16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP16  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP16
DgiDB (Drug Gene Interaction Database)USP16
DoCM (Curated mutations)USP16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP16 (select a term)
intoGenUSP16
Cancer3DUSP16(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604735   
Orphanet
MedgenUSP16
Genetic Testing Registry USP16
NextProtQ9Y5T5 [Medical]
TSGene10600
GENETestsUSP16
Target ValidationUSP16
Huge Navigator USP16 [HugePedia]
snp3D : Map Gene to Disease10600
BioCentury BCIQUSP16
ClinGenUSP16
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10600
Chemical/Pharm GKB GenePA37240
Clinical trialUSP16
Miscellaneous
canSAR (ICR)USP16 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP16
EVEXUSP16
GoPubMedUSP16
iHOPUSP16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:02:08 CEST 2017

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