USP16 (ubiquitin specific peptidase 16)

2009-08-01  

Identity

HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
UBP-M,UBPM
FUSION GENES

Other Information

Locus ID:

NCBI: 10600
MIM: 604735
HGNC: 12614
Ensembl: ENSG00000156256

Variants:

dbSNP: 10600
ClinVar: 10600
TCGA: ENSG00000156256
COSMIC: USP16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156256ENST00000334352Q9Y5T5
ENSG00000156256ENST00000399973H9KVB6
ENSG00000156256ENST00000399975Q9Y5T5
ENSG00000156256ENST00000399976Q9Y5T5

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179143552007Regulation of cell cycle progression and gene expression by H2A deubiquitination.122
240257672013Usp16 contributes to somatic stem-cell defects in Down's syndrome.42
189259612008Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.36
253050192014The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage.26
275864452016An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.19
175125432007Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.18
276339972016USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells.12
263236892015Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis.11
240134212013Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression.6
311353812019USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance.2

Citation

Dessen P

USP16 (ubiquitin specific peptidase 16)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51008/usp16