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USP17L2 (ubiquitin specific peptidase 17-like family member 2)

Identity

Alias_namesubiquitin specific peptidase 17-like 2
Alias_symbol (synonym)DUB3
Other aliasDUB-3
USP17
HGNC (Hugo) USP17L2
LocusID (NCBI) 377630
Atlas_Id 51473
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 12137168 and ends at 12138760 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP17L2   34434
Cards
Entrez_Gene (NCBI)USP17L2  377630  ubiquitin specific peptidase 17-like family member 2
AliasesDUB-3; DUB3; USP17
GeneCards (Weizmann)USP17L2
Ensembl hg19 (Hinxton)ENSG00000223443 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000223443 [Gene_View]  chr8:12137168-12138760 [Contig_View]  USP17L2 [Vega]
ICGC DataPortalENSG00000223443
TCGA cBioPortalUSP17L2
AceView (NCBI)USP17L2
Genatlas (Paris)USP17L2
WikiGenes377630
SOURCE (Princeton)USP17L2
Genetics Home Reference (NIH)USP17L2
Genomic and cartography
GoldenPath hg38 (UCSC)USP17L2  -     chr8:12137168-12138760 -  8p23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP17L2  -     8p23.1   [Description]    (hg19-Feb_2009)
EnsemblUSP17L2 - 8p23.1 [CytoView hg19]  USP17L2 - 8p23.1 [CytoView hg38]
Mapping of homologs : NCBIUSP17L2 [Mapview hg19]  USP17L2 [Mapview hg38]
OMIM610186   
Gene and transcription
Genbank (Entrez)AY509884 BC156290 BC157073
RefSeq transcript (Entrez)NM_201402
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP17L2
Cluster EST : UnigeneHs.531448 [ NCBI ]
CGAP (NCI)Hs.531448
Alternative Splicing GalleryENSG00000223443
Gene ExpressionUSP17L2 [ NCBI-GEO ]   USP17L2 [ EBI - ARRAY_EXPRESS ]   USP17L2 [ SEEK ]   USP17L2 [ MEM ]
Gene Expression Viewer (FireBrowse)USP17L2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)377630
GTEX Portal (Tissue expression)USP17L2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6R6M4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6R6M4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6R6M4
Splice isoforms : SwissVarQ6R6M4
PhosPhoSitePlusQ6R6M4
Domaine pattern : Prosite (Expaxy)USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP17L2
DMDM Disease mutations377630
Blocks (Seattle)USP17L2
SuperfamilyQ6R6M4
Human Protein AtlasENSG00000223443
Peptide AtlasQ6R6M4
HPRD16844
IPIIPI00883911   
Protein Interaction databases
DIP (DOE-UCLA)Q6R6M4
IntAct (EBI)Q6R6M4
FunCoupENSG00000223443
BioGRIDUSP17L2
STRING (EMBL)USP17L2
ZODIACUSP17L2
Ontologies - Pathways
QuickGOQ6R6M4
Ontology : AmiGOcell cycle checkpoint  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  endoplasmic reticulum membrane  cytosol  ubiquitin-dependent protein catabolic process  apoptotic process  mitotic cell cycle checkpoint  negative regulation of protein processing  protein deubiquitination  protein deubiquitination  regulation of cell migration  negative regulation of histone deacetylation  negative regulation of GTPase activity  thiol-dependent ubiquitinyl hydrolase activity  regulation of cell proliferation  regulation of apoptotic process  positive regulation of GTPase activity  regulation of defense response to virus by host  protein K63-linked deubiquitination  protein K63-linked deubiquitination  protein K48-linked deubiquitination  CAAX-box protein processing  negative regulation of protein targeting to membrane  regulation of ruffle assembly  positive regulation of MDA-5 signaling pathway  positive regulation of RIG-I signaling pathway  
Ontology : EGO-EBIcell cycle checkpoint  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  endoplasmic reticulum membrane  cytosol  ubiquitin-dependent protein catabolic process  apoptotic process  mitotic cell cycle checkpoint  negative regulation of protein processing  protein deubiquitination  protein deubiquitination  regulation of cell migration  negative regulation of histone deacetylation  negative regulation of GTPase activity  thiol-dependent ubiquitinyl hydrolase activity  regulation of cell proliferation  regulation of apoptotic process  positive regulation of GTPase activity  regulation of defense response to virus by host  protein K63-linked deubiquitination  protein K63-linked deubiquitination  protein K48-linked deubiquitination  CAAX-box protein processing  negative regulation of protein targeting to membrane  regulation of ruffle assembly  positive regulation of MDA-5 signaling pathway  positive regulation of RIG-I signaling pathway  
NDEx NetworkUSP17L2
Atlas of Cancer Signalling NetworkUSP17L2
Wikipedia pathwaysUSP17L2
Orthology - Evolution
OrthoDB377630
GeneTree (enSembl)ENSG00000223443
Phylogenetic Trees/Animal Genes : TreeFamUSP17L2
HOVERGENQ6R6M4
HOGENOMQ6R6M4
Homologs : HomoloGeneUSP17L2
Homology/Alignments : Family Browser (UCSC)USP17L2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP17L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP17L2
dbVarUSP17L2
ClinVarUSP17L2
1000_GenomesUSP17L2 
Exome Variant ServerUSP17L2
ExAC (Exome Aggregation Consortium)USP17L2 (select the gene name)
Genetic variants : HAPMAP377630
Genomic Variants (DGV)USP17L2 [DGVbeta]
DECIPHERUSP17L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP17L2 
Mutations
ICGC Data PortalUSP17L2 
TCGA Data PortalUSP17L2 
Broad Tumor PortalUSP17L2
OASIS PortalUSP17L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP17L2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP17L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP17L2
DgiDB (Drug Gene Interaction Database)USP17L2
DoCM (Curated mutations)USP17L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP17L2 (select a term)
intoGenUSP17L2
Cancer3DUSP17L2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610186   
Orphanet
MedgenUSP17L2
Genetic Testing Registry USP17L2
NextProtQ6R6M4 [Medical]
TSGene377630
GENETestsUSP17L2
Target ValidationUSP17L2
Huge Navigator USP17L2 [HugePedia]
snp3D : Map Gene to Disease377630
BioCentury BCIQUSP17L2
ClinGenUSP17L2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD377630
Chemical/Pharm GKB GenePA165586023
Clinical trialUSP17L2
Miscellaneous
canSAR (ICR)USP17L2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP17L2
EVEXUSP17L2
GoPubMedUSP17L2
iHOPUSP17L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:09 CEST 2017

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