USP18 (ubiquitin specific peptidase 18)

2007-10-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
ISG43,PTORCH2,UBP43
FUSION GENES

Other Information

Locus ID:

NCBI: 11274
MIM: 607057
HGNC: 12616
Ensembl: ENSG00000184979

Variants:

dbSNP: 11274
ClinVar: 11274
TCGA: ENSG00000184979
COSMIC: USP18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184979ENST00000215794Q9UMW8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Regulation of IFNA signalingREACTOMER-HSA-912694
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA36184STAT2GenePathwayassociated26111151

References

Pubmed IDYearTitleCitations
273258882016Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome.51
200681732010Identification of USP18 as an important regulator of the susceptibility to IFN-alpha and drug-induced apoptosis.35
260087452015Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling.30
281655102017STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.29
226771942012Interferon-γ-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C.28
231520552012USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis.27
227314912012USP18 establishes the transcriptional and anti-proliferative interferon α/β differential.26
281655092017Structural basis of the specificity of USP18 toward ISG15.25
215929592011Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.24
262400162015USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.24

Citation

Dessen P

USP18 (ubiquitin specific peptidase 18)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49760/usp18