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USP18 (ubiquitin specific peptidase 18)

Identity

Alias_namesubiquitin specific protease 18
Other aliasISG43
PTORCH2
UBP43
HGNC (Hugo) USP18
LocusID (NCBI) 11274
Atlas_Id 49760
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 18149991 and ends at 18177395 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GGT5 (22q11.23) / USP18 (22q11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP18   12616
Cards
Entrez_Gene (NCBI)USP18  11274  ubiquitin specific peptidase 18
AliasesISG43; PTORCH2; UBP43
GeneCards (Weizmann)USP18
Ensembl hg19 (Hinxton)ENSG00000184979 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184979 [Gene_View]  chr22:18149991-18177395 [Contig_View]  USP18 [Vega]
ICGC DataPortalENSG00000184979
TCGA cBioPortalUSP18
AceView (NCBI)USP18
Genatlas (Paris)USP18
WikiGenes11274
SOURCE (Princeton)USP18
Genetics Home Reference (NIH)USP18
Genomic and cartography
GoldenPath hg38 (UCSC)USP18  -     chr22:18149991-18177395 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP18  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblUSP18 - 22q11.21 [CytoView hg19]  USP18 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIUSP18 [Mapview hg19]  USP18 [Mapview hg38]
OMIM607057   617397   
Gene and transcription
Genbank (Entrez)AF176642 AI222587 AJ243526 AK313385 AL136690
RefSeq transcript (Entrez)NM_017414
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP18
Cluster EST : UnigeneHs.38260 [ NCBI ]
CGAP (NCI)Hs.38260
Alternative Splicing GalleryENSG00000184979
Gene ExpressionUSP18 [ NCBI-GEO ]   USP18 [ EBI - ARRAY_EXPRESS ]   USP18 [ SEEK ]   USP18 [ MEM ]
Gene Expression Viewer (FireBrowse)USP18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11274
GTEX Portal (Tissue expression)USP18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UMW8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UMW8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UMW8
Splice isoforms : SwissVarQ9UMW8
Catalytic activity : Enzyme3.4.19.- [ Enzyme-Expasy ]   3.4.19.-3.4.19.- [ IntEnz-EBI ]   3.4.19.- [ BRENDA ]   3.4.19.- [ KEGG ]   
PhosPhoSitePlusQ9UMW8
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP18
DMDM Disease mutations11274
Blocks (Seattle)USP18
SuperfamilyQ9UMW8
Human Protein AtlasENSG00000184979
Peptide AtlasQ9UMW8
HPRD06136
IPIIPI00183040   IPI01015422   
Protein Interaction databases
DIP (DOE-UCLA)Q9UMW8
IntAct (EBI)Q9UMW8
FunCoupENSG00000184979
BioGRIDUSP18
STRING (EMBL)USP18
ZODIACUSP18
Ontologies - Pathways
QuickGOQ9UMW8
Ontology : AmiGOthiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytosol  cytosol  ubiquitin-dependent protein catabolic process  protein deubiquitination  ISG15-specific protease activity  thiol-dependent ubiquitinyl hydrolase activity  regulation of type I interferon-mediated signaling pathway  
Ontology : EGO-EBIthiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytosol  cytosol  ubiquitin-dependent protein catabolic process  protein deubiquitination  ISG15-specific protease activity  thiol-dependent ubiquitinyl hydrolase activity  regulation of type I interferon-mediated signaling pathway  
NDEx NetworkUSP18
Atlas of Cancer Signalling NetworkUSP18
Wikipedia pathwaysUSP18
Orthology - Evolution
OrthoDB11274
GeneTree (enSembl)ENSG00000184979
Phylogenetic Trees/Animal Genes : TreeFamUSP18
HOVERGENQ9UMW8
HOGENOMQ9UMW8
Homologs : HomoloGeneUSP18
Homology/Alignments : Family Browser (UCSC)USP18
Gene fusions - Rearrangements
Fusion : MitelmanGGT5/USP18 [22q11.23/22q11.21]  [t(22;22)(q11;q11)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP18
dbVarUSP18
ClinVarUSP18
1000_GenomesUSP18 
Exome Variant ServerUSP18
ExAC (Exome Aggregation Consortium)USP18 (select the gene name)
Genetic variants : HAPMAP11274
Genomic Variants (DGV)USP18 [DGVbeta]
DECIPHERUSP18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP18 
Mutations
ICGC Data PortalUSP18 
TCGA Data PortalUSP18 
Broad Tumor PortalUSP18
OASIS PortalUSP18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP18
DgiDB (Drug Gene Interaction Database)USP18
DoCM (Curated mutations)USP18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP18 (select a term)
intoGenUSP18
Cancer3DUSP18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607057    617397   
Orphanet
MedgenUSP18
Genetic Testing Registry USP18
NextProtQ9UMW8 [Medical]
TSGene11274
GENETestsUSP18
Target ValidationUSP18
Huge Navigator USP18 [HugePedia]
snp3D : Map Gene to Disease11274
BioCentury BCIQUSP18
ClinGenUSP18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11274
Chemical/Pharm GKB GenePA37242
Clinical trialUSP18
Miscellaneous
canSAR (ICR)USP18 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP18
EVEXUSP18
GoPubMedUSP18
iHOPUSP18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:09 CEST 2017

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