USP19 (ubiquitin specific peptidase 19)

2011-08-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
ZMYND9
FUSION GENES

Other Information

Locus ID:

NCBI: 10869
MIM: 614471
HGNC: 12617
Ensembl: ENSG00000172046

Variants:

dbSNP: 10869
ClinVar: 10869
TCGA: ENSG00000172046
COSMIC: USP19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172046ENST00000306026A0A0A0MR08
ENSG00000172046ENST00000398888O94966
ENSG00000172046ENST00000398896E7ESU0
ENSG00000172046ENST00000417901O94966
ENSG00000172046ENST00000434032O94966
ENSG00000172046ENST00000453664O94966
ENSG00000172046ENST00000465902A0A590UK03
ENSG00000172046ENST00000479073H0YB23

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

References

Pubmed IDYearTitleCitations
228105852012Viral immune modulators perturb the human molecular network by common and unique strategies.109
194658872009The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates.54
218495052011The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.32
269880332016USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1.32
221281622012Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia.23
243569572014Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.15
212642182011Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.9
268082602016Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone.9
290934752017HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19.8
260481422015Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.6

Citation

Dessen P

USP19 (ubiquitin specific peptidase 19)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52334/usp19