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USP19 (ubiquitin specific peptidase 19)

Identity

Alias_namesubiquitin specific protease 19
Alias_symbol (synonym)KIAA0891
ZMYND9
Other alias
HGNC (Hugo) USP19
LocusID (NCBI) 10869
Atlas_Id 52334
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49108673 and ends at 49120938 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AAK1 (2p13.3) / USP19 (3p21.31)QARS (3p21.31) / USP19 (3p21.31)TG (8q24.22) / USP19 (3p21.31)
USP19 (3p21.31) / POMT1 (9q34.13)USP19 (3p21.31) / SPOCD1 (1p35.2)USP19 (3p21.31) / VEPH1 (3q25.31)
QARS 3p21.31 / USP19 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP19   12617
Cards
Entrez_Gene (NCBI)USP19  10869  ubiquitin specific peptidase 19
AliasesZMYND9
GeneCards (Weizmann)USP19
Ensembl hg19 (Hinxton)ENSG00000172046 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172046 [Gene_View]  chr3:49108673-49120938 [Contig_View]  USP19 [Vega]
ICGC DataPortalENSG00000172046
TCGA cBioPortalUSP19
AceView (NCBI)USP19
Genatlas (Paris)USP19
WikiGenes10869
SOURCE (Princeton)USP19
Genetics Home Reference (NIH)USP19
Genomic and cartography
GoldenPath hg38 (UCSC)USP19  -     chr3:49108673-49120938 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP19  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblUSP19 - 3p21.31 [CytoView hg19]  USP19 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIUSP19 [Mapview hg19]  USP19 [Mapview hg38]
OMIM614471   
Gene and transcription
Genbank (Entrez)AB020698 AK294756 AK296447 AK300425 BC014934
RefSeq transcript (Entrez)NM_001199160 NM_001199161 NM_001199162 NM_006677
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP19
Cluster EST : UnigeneHs.734003 [ NCBI ]
CGAP (NCI)Hs.734003
Alternative Splicing GalleryENSG00000172046
Gene ExpressionUSP19 [ NCBI-GEO ]   USP19 [ EBI - ARRAY_EXPRESS ]   USP19 [ SEEK ]   USP19 [ MEM ]
Gene Expression Viewer (FireBrowse)USP19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10869
GTEX Portal (Tissue expression)USP19
Human Protein AtlasENSG00000172046-USP19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94966   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94966  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94966
Splice isoforms : SwissVarO94966
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusO94966
Domaine pattern : Prosite (Expaxy)CS (PS51203)    USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)    ZF_MYND_1 (PS01360)    ZF_MYND_2 (PS50865)   
Domains : Interpro (EBI)CS_dom    HSP20-like_chaperone    Peptidase_C19_UCH    USP_CS    USP_dom    Znf_MYND   
Domain families : Pfam (Sanger)CS (PF04969)    UCH (PF00443)    zf-MYND (PF01753)   
Domain families : Pfam (NCBI)pfam04969    pfam00443    pfam01753   
Conserved Domain (NCBI)USP19
DMDM Disease mutations10869
Blocks (Seattle)USP19
PDB (SRS)1WH0    4X3G   
PDB (PDBSum)1WH0    4X3G   
PDB (IMB)1WH0    4X3G   
PDB (RSDB)1WH0    4X3G   
Structural Biology KnowledgeBase1WH0    4X3G   
SCOP (Structural Classification of Proteins)1WH0    4X3G   
CATH (Classification of proteins structures)1WH0    4X3G   
SuperfamilyO94966
Human Protein Atlas [tissue]ENSG00000172046-USP19 [tissue]
Peptide AtlasO94966
HPRD18278
IPIIPI00016589   IPI00853489   IPI00797161   IPI00908478   IPI00789672   IPI01010013   IPI00796756   IPI00654743   IPI00927399   IPI00927646   IPI00941767   IPI00981313   
Protein Interaction databases
DIP (DOE-UCLA)O94966
IntAct (EBI)O94966
FunCoupENSG00000172046
BioGRIDUSP19
STRING (EMBL)USP19
ZODIACUSP19
Ontologies - Pathways
QuickGOO94966
Ontology : AmiGOthiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  endoplasmic reticulum membrane  cytosol  cytosol  integral component of membrane  protein deubiquitination  protein deubiquitination  protein deubiquitination  ubiquitin-dependent ERAD pathway  ubiquitin protein ligase binding  regulation of protein stability  response to endoplasmic reticulum stress  thiol-dependent ubiquitinyl hydrolase activity  metal ion binding  negative regulation of skeletal muscle tissue development  protein stabilization  Hsp90 protein binding  protein K48-linked deubiquitination  positive regulation of cell cycle process  regulation of cellular response to hypoxia  negative regulation of proteasomal protein catabolic process  regulation of ERAD pathway  Lys48-specific deubiquitinase activity  
Ontology : EGO-EBIthiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  endoplasmic reticulum membrane  cytosol  cytosol  integral component of membrane  protein deubiquitination  protein deubiquitination  protein deubiquitination  ubiquitin-dependent ERAD pathway  ubiquitin protein ligase binding  regulation of protein stability  response to endoplasmic reticulum stress  thiol-dependent ubiquitinyl hydrolase activity  metal ion binding  negative regulation of skeletal muscle tissue development  protein stabilization  Hsp90 protein binding  protein K48-linked deubiquitination  positive regulation of cell cycle process  regulation of cellular response to hypoxia  negative regulation of proteasomal protein catabolic process  regulation of ERAD pathway  Lys48-specific deubiquitinase activity  
NDEx NetworkUSP19
Atlas of Cancer Signalling NetworkUSP19
Wikipedia pathwaysUSP19
Orthology - Evolution
OrthoDB10869
GeneTree (enSembl)ENSG00000172046
Phylogenetic Trees/Animal Genes : TreeFamUSP19
HOVERGENO94966
HOGENOMO94966
Homologs : HomoloGeneUSP19
Homology/Alignments : Family Browser (UCSC)USP19
Gene fusions - Rearrangements
Fusion : MitelmanQARS/USP19 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion: TCGA_MDACCQARS 3p21.31 USP19 3p21.31 BRCA
Tumor Fusion PortalUSP19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP19
dbVarUSP19
ClinVarUSP19
1000_GenomesUSP19 
Exome Variant ServerUSP19
ExAC (Exome Aggregation Consortium)ENSG00000172046
GNOMAD BrowserENSG00000172046
Genetic variants : HAPMAP10869
Genomic Variants (DGV)USP19 [DGVbeta]
DECIPHERUSP19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP19 
Mutations
ICGC Data PortalUSP19 
TCGA Data PortalUSP19 
Broad Tumor PortalUSP19
OASIS PortalUSP19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP19
DgiDB (Drug Gene Interaction Database)USP19
DoCM (Curated mutations)USP19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP19 (select a term)
intoGenUSP19
Cancer3DUSP19(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614471   
Orphanet
DisGeNETUSP19
MedgenUSP19
Genetic Testing Registry USP19
NextProtO94966 [Medical]
TSGene10869
GENETestsUSP19
Target ValidationUSP19
Huge Navigator USP19 [HugePedia]
snp3D : Map Gene to Disease10869
BioCentury BCIQUSP19
ClinGenUSP19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10869
Chemical/Pharm GKB GenePA37243
Clinical trialUSP19
Miscellaneous
canSAR (ICR)USP19 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP19
EVEXUSP19
GoPubMedUSP19
iHOPUSP19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:41:01 CET 2017

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