USP20 (ubiquitin specific peptidase 20)

2015-02-01  

Identity

HGNC
USP20
LOCATION
9q34.11
LOCUSID
10868
ALIAS
LSFR3A,VDU2,hVDU2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10868
MIM: 615143
HGNC: 12619
Ensembl: ENSG00000136878

Variants:

dbSNP: 10868
ClinVar: 10868
TCGA: ENSG00000136878
COSMIC: USP20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136878ENST00000315480Q9Y2K6
ENSG00000136878ENST00000358355Q9Y2K6
ENSG00000136878ENST00000372429Q9Y2K6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194241802009The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.82
157760162005VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.68
128654082003Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.52
215253542011Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.46
256666162015Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.15
249234432014Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination.12
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
298671302018USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization.8
294870852018The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.6
257088582015Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20.5

Citation

Dessen P

USP20 (ubiquitin specific peptidase 20)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55017/usp20