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USP21 (ubiquitin specific peptidase 21)

Identity

Alias_namesUSP23
ubiquitin specific protease 21
Alias_symbol (synonym)USP16
Other alias
HGNC (Hugo) USP21
LocusID (NCBI) 27005
Atlas_Id 75549
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 161159464 and ends at 161165726 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EFNA3 (1q22) / USP21 (1q23.3)USP21 (1q23.3) / NECTIN4 (1q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP21   12620
Cards
Entrez_Gene (NCBI)USP21  27005  ubiquitin specific peptidase 21
AliasesUSP16; USP23
GeneCards (Weizmann)USP21
Ensembl hg19 (Hinxton)ENSG00000143258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143258 [Gene_View]  chr1:161159464-161165726 [Contig_View]  USP21 [Vega]
ICGC DataPortalENSG00000143258
TCGA cBioPortalUSP21
AceView (NCBI)USP21
Genatlas (Paris)USP21
WikiGenes27005
SOURCE (Princeton)USP21
Genetics Home Reference (NIH)USP21
Genomic and cartography
GoldenPath hg38 (UCSC)USP21  -     chr1:161159464-161165726 +  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP21  -     1q23.3   [Description]    (hg19-Feb_2009)
EnsemblUSP21 - 1q23.3 [CytoView hg19]  USP21 - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBIUSP21 [Mapview hg19]  USP21 [Mapview hg38]
OMIM604729   
Gene and transcription
Genbank (Entrez)AB208899 AF177758 AF217979 AF233442 AI038040
RefSeq transcript (Entrez)NM_001014443 NM_001319847 NM_001319848 NM_012475
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP21
Cluster EST : UnigeneHs.8015 [ NCBI ]
CGAP (NCI)Hs.8015
Alternative Splicing GalleryENSG00000143258
Gene ExpressionUSP21 [ NCBI-GEO ]   USP21 [ EBI - ARRAY_EXPRESS ]   USP21 [ SEEK ]   USP21 [ MEM ]
Gene Expression Viewer (FireBrowse)USP21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27005
GTEX Portal (Tissue expression)USP21
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UK80   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UK80  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UK80
Splice isoforms : SwissVarQ9UK80
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ9UK80
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP21
DMDM Disease mutations27005
Blocks (Seattle)USP21
PDB (SRS)2Y5B    3I3T    3MTN   
PDB (PDBSum)2Y5B    3I3T    3MTN   
PDB (IMB)2Y5B    3I3T    3MTN   
PDB (RSDB)2Y5B    3I3T    3MTN   
Structural Biology KnowledgeBase2Y5B    3I3T    3MTN   
SCOP (Structural Classification of Proteins)2Y5B    3I3T    3MTN   
CATH (Classification of proteins structures)2Y5B    3I3T    3MTN   
SuperfamilyQ9UK80
Human Protein AtlasENSG00000143258
Peptide AtlasQ9UK80
HPRD05291
IPIIPI00007262   IPI00873033   IPI00376946   IPI00182036   IPI00385643   
Protein Interaction databases
DIP (DOE-UCLA)Q9UK80
IntAct (EBI)Q9UK80
FunCoupENSG00000143258
BioGRIDUSP21
STRING (EMBL)USP21
ZODIACUSP21
Ontologies - Pathways
QuickGOQ9UK80
Ontology : AmiGOtranscription coactivator activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  cellular_component  nucleoplasm  nucleoplasm  cytosol  cytosol  plasma membrane  transcription, DNA-templated  ubiquitin-dependent protein catabolic process  cysteine-type peptidase activity  cysteine-type peptidase activity  histone deubiquitination  protein deubiquitination  NEDD8-specific protease activity  neuron projection development  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  positive regulation of transcription, DNA-templated  metal ion binding  
Ontology : EGO-EBItranscription coactivator activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  cellular_component  nucleoplasm  nucleoplasm  cytosol  cytosol  plasma membrane  transcription, DNA-templated  ubiquitin-dependent protein catabolic process  cysteine-type peptidase activity  cysteine-type peptidase activity  histone deubiquitination  protein deubiquitination  NEDD8-specific protease activity  neuron projection development  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  positive regulation of transcription, DNA-templated  metal ion binding  
NDEx NetworkUSP21
Atlas of Cancer Signalling NetworkUSP21
Wikipedia pathwaysUSP21
Orthology - Evolution
OrthoDB27005
GeneTree (enSembl)ENSG00000143258
Phylogenetic Trees/Animal Genes : TreeFamUSP21
HOVERGENQ9UK80
HOGENOMQ9UK80
Homologs : HomoloGeneUSP21
Homology/Alignments : Family Browser (UCSC)USP21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP21
dbVarUSP21
ClinVarUSP21
1000_GenomesUSP21 
Exome Variant ServerUSP21
ExAC (Exome Aggregation Consortium)USP21 (select the gene name)
Genetic variants : HAPMAP27005
Genomic Variants (DGV)USP21 [DGVbeta]
DECIPHERUSP21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP21 
Mutations
ICGC Data PortalUSP21 
TCGA Data PortalUSP21 
Broad Tumor PortalUSP21
OASIS PortalUSP21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP21
DgiDB (Drug Gene Interaction Database)USP21
DoCM (Curated mutations)USP21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP21 (select a term)
intoGenUSP21
Cancer3DUSP21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604729   
Orphanet
MedgenUSP21
Genetic Testing Registry USP21
NextProtQ9UK80 [Medical]
TSGene27005
GENETestsUSP21
Target ValidationUSP21
Huge Navigator USP21 [HugePedia]
snp3D : Map Gene to Disease27005
BioCentury BCIQUSP21
ClinGenUSP21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27005
Chemical/Pharm GKB GenePA37246
Clinical trialUSP21
Miscellaneous
canSAR (ICR)USP21 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP21
EVEXUSP21
GoPubMedUSP21
iHOPUSP21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:43:25 CEST 2017

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