Atlas of Genetics and Cytogenetics in Oncology and Haematology

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USP22 (ubiquitin specific peptidase 22)

Identity

Alias (NCBI)USP3L
HGNC (Hugo) USP22
HGNC Alias symbKIAA1063
HGNC Previous nameUSP3L
HGNC Previous nameubiquitin specific protease 22
 ubiquitin specific peptidase 3-like
LocusID (NCBI) 23326
Atlas_Id 43796
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 20999596 and ends at 21043011 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BOLA3 (2p13.1) / USP22 (17p11.2)EXOC7 (17q25.1) / USP22 (17p11.2)IFNAR1 (21q22.11) / USP22 (17p11.2)
LIMA1 (12q13.12) / USP22 (17p11.2)MRPL52 (14q11.2) / USP22 (17p11.2)NOL7 (6p23) / USP22 (17p11.2)
RMI2 (16p13.13) / USP22 (17p11.2)TMEM232 (5q22.1) / USP22 (17p11.2)UCHL1 (4p13) / USP22 (17p11.2)
USP22 (17p11.2) / ATP2A3 (17p13.2)USP22 (17p11.2) / CA7 (16q22.1)USP22 (17p11.2) / DHCR24 (1p32.3)
USP22 (17p11.2) / MYH10 (17p13.1)USP22 (17p11.2) / MYO19 (17q12)USP22 (17p11.2) / ORC6 (16q11.2)
USP22 (17p11.2) / PRIM1 (12q13.3)USP22 (17p11.2) / RUSC2 (9p13.3)USP22 (17p11.2) / SLC39A11 (17q24.3)
USP22 (17p11.2) / SPACA3 (17q11.2)USP22 (17p11.2) / USP22 (17p11.2)EXOC7 17q25.1 / USP22 17p11.2
USP22 17p11.2 / ATP2A3 17p13.2USP22 17p11.2 / MYH10 17p13.1USP22 17p11.2 / MYO19 17q12
USP22 17p11.2 / SLC39A11 17q24.3USP22 17p11.2 / SPACA3 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(16;17)(q22;p11) CA7/USP22
t(16;17)(q22;p11) USP22/CA7

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(12;17)(q13;p11) LIMA1/USP22
t(14;17)(q11;p11) MRPL52/USP22
t(17;17)(p11;p13) USP22/ATP2A3
t(17;17)(p11;p13) USP22/MYH10
t(17;17)(p11;q11) USP22/SPACA3
t(17;17)(p11;q12) USP22/MYO19
t(17;17)(p11;q25) EXOC7/USP22
t(17;17)(p11;q25) USP22/SLC39A11

External links

Nomenclature
HGNC (Hugo)USP22   12621
Cards
Entrez_Gene (NCBI)USP22  23326  ubiquitin specific peptidase 22
AliasesUSP3L
GeneCards (Weizmann)USP22
Ensembl hg19 (Hinxton)ENSG00000124422 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124422 [Gene_View]  ENSG00000124422 [Sequence]  chr17:20999596-21043011 [Contig_View]  USP22 [Vega]
ICGC DataPortalENSG00000124422
TCGA cBioPortalUSP22
AceView (NCBI)USP22
Genatlas (Paris)USP22
WikiGenes23326
SOURCE (Princeton)USP22
Genetics Home Reference (NIH)USP22
Genomic and cartography
GoldenPath hg38 (UCSC)USP22  -     chr17:20999596-21043011 -  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP22  -     17p11.2   [Description]    (hg19-Feb_2009)
GoldenPathUSP22 - 17p11.2 [CytoView hg19]  USP22 - 17p11.2 [CytoView hg38]
ImmunoBaseENSG00000124422
genome Data Viewer NCBIUSP22 [Mapview hg19]  
OMIM612116   
Gene and transcription
Genbank (Entrez)AB028986 AK025331 AK130677 AL049258 AL110213
RefSeq transcript (Entrez)NM_015276
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP22
Alternative Splicing GalleryENSG00000124422
Gene ExpressionUSP22 [ NCBI-GEO ]   USP22 [ EBI - ARRAY_EXPRESS ]   USP22 [ SEEK ]   USP22 [ MEM ]
Gene Expression Viewer (FireBrowse)USP22 [ Firebrowse - Broad ]
GenevisibleExpression of USP22 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23326
GTEX Portal (Tissue expression)USP22
Human Protein AtlasENSG00000124422-USP22 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPT9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPT9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPT9
Splice isoforms : SwissVarQ9UPT9
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UPT9
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)    ZF_UBP (PS50271)   
Domains : Interpro (EBI)Papain-like_cys_pep_sf    Peptidase_C19_UCH    USP_CS    USP_dom    Znf_RING/FYVE/PHD    Znf_UBP   
Domain families : Pfam (Sanger)UCH (PF00443)    zf-UBP (PF02148)   
Domain families : Pfam (NCBI)pfam00443    pfam02148   
Conserved Domain (NCBI)USP22
DMDM Disease mutations23326
Blocks (Seattle)USP22
SuperfamilyQ9UPT9
Human Protein Atlas [tissue]ENSG00000124422-USP22 [tissue]
Peptide AtlasQ9UPT9
IPIIPI00852960   IPI00923593   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPT9
IntAct (EBI)Q9UPT9
FunCoupENSG00000124422
BioGRIDUSP22
STRING (EMBL)USP22
ZODIACUSP22
Ontologies - Pathways
QuickGOQ9UPT9
Ontology : AmiGOSAGA complex  transcription coactivator activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  ubiquitin-dependent protein catabolic process  cell cycle  zinc ion binding  embryo development ending in birth or egg hatching  H4 histone acetyltransferase activity  histone ubiquitination  histone deubiquitination  protein deubiquitination  protein deubiquitination  enzyme binding  nuclear receptor transcription coactivator activity  histone H4 acetylation  positive regulation of transcription, DNA-templated  positive regulation of mitotic cell cycle  SAGA-type complex  
Ontology : EGO-EBISAGA complex  transcription coactivator activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  ubiquitin-dependent protein catabolic process  cell cycle  zinc ion binding  embryo development ending in birth or egg hatching  H4 histone acetyltransferase activity  histone ubiquitination  histone deubiquitination  protein deubiquitination  protein deubiquitination  enzyme binding  nuclear receptor transcription coactivator activity  histone H4 acetylation  positive regulation of transcription, DNA-templated  positive regulation of mitotic cell cycle  SAGA-type complex  
NDEx NetworkUSP22
Atlas of Cancer Signalling NetworkUSP22
Wikipedia pathwaysUSP22
Orthology - Evolution
OrthoDB23326
GeneTree (enSembl)ENSG00000124422
Phylogenetic Trees/Animal Genes : TreeFamUSP22
HOGENOMQ9UPT9
Homologs : HomoloGeneUSP22
Homology/Alignments : Family Browser (UCSC)USP22
Gene fusions - Rearrangements
Fusion : MitelmanEXOC7/USP22 [17q25.1/17p11.2]  
Fusion : MitelmanLIMA1/USP22 [12q13.12/17p11.2]  
Fusion : MitelmanMRPL52/USP22 [14q11.2/17p11.2]  
Fusion : MitelmanUSP22/ATP2A3 [17p11.2/17p13.2]  
Fusion : MitelmanUSP22/CA7 [17p11.2/16q22.1]  
Fusion : MitelmanUSP22/MYH10 [17p11.2/17p13.1]  
Fusion : MitelmanUSP22/MYO19 [17p11.2/17q12]  
Fusion : MitelmanUSP22/SLC39A11 [17p11.2/17q24.3]  
Fusion : MitelmanUSP22/SPACA3 [17p11.2/17q11.2]  
Fusion PortalEXOC7 17q25.1 USP22 17p11.2 BRCA
Fusion PortalUSP22 17p11.2 ATP2A3 17p13.2 PRAD
Fusion PortalUSP22 17p11.2 MYH10 17p13.1 BRCA
Fusion PortalUSP22 17p11.2 MYO19 17q12 BRCA
Fusion PortalUSP22 17p11.2 SLC39A11 17q24.3 BRCA
Fusion PortalUSP22 17p11.2 SPACA3 17q11.2 BRCA
Fusion : QuiverUSP22
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP22
dbVarUSP22
ClinVarUSP22
MonarchUSP22
1000_GenomesUSP22 
Exome Variant ServerUSP22
GNOMAD BrowserENSG00000124422
Varsome BrowserUSP22
Genetic variants : HAPMAP23326
Genomic Variants (DGV)USP22 [DGVbeta]
DECIPHERUSP22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP22 
Mutations
ICGC Data PortalUSP22 
TCGA Data PortalUSP22 
Broad Tumor PortalUSP22
OASIS PortalUSP22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP22  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUSP22
Mutations and Diseases : HGMDUSP22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP22
DgiDB (Drug Gene Interaction Database)USP22
DoCM (Curated mutations)USP22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP22 (select a term)
intoGenUSP22
Cancer3DUSP22(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612116   
Orphanet
DisGeNETUSP22
MedgenUSP22
Genetic Testing Registry USP22
NextProtQ9UPT9 [Medical]
TSGene23326
GENETestsUSP22
Target ValidationUSP22
Huge Navigator USP22 [HugePedia]
snp3D : Map Gene to Disease23326
BioCentury BCIQUSP22
ClinGenUSP22
Clinical trials, drugs, therapy
Protein Interactions : CTD23326
Pharm GKB GenePA37247
Clinical trialUSP22
Miscellaneous
canSAR (ICR)USP22 (select the gene name)
HarmonizomeUSP22
DataMed IndexUSP22
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP22
EVEXUSP22
GoPubMedUSP22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:38:28 CEST 2020
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