USP22 (ubiquitin specific peptidase 22)

2007-02-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
USP3L
FUSION GENES

Other Information

Locus ID:

NCBI: 23326
MIM: 612116
HGNC: 12621
Ensembl: ENSG00000124422

Variants:

dbSNP: 23326
ClinVar: 23326
TCGA: ENSG00000124422
COSMIC: USP22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124422ENST00000261497Q9UPT9
ENSG00000124422ENST00000476111K7ERX6
ENSG00000124422ENST00000537526Q9UPT9
ENSG00000124422ENST00000579645J3QRV6
ENSG00000124422ENST00000582335J3QS30
ENSG00000124422ENST00000584538K7ESK0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159313892005Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.297
182069722008A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.157
182069732008The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.157
184695332008USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A.63
217468792011The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements.50
217790032011USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1.46
251114862014Functions of SAGA in development and disease.40
213375582011Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.38
216917492011Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer.38
241971342014USP22 regulates oncogenic signaling pathways to drive lethal cancer progression.35

Citation

Dessen P

USP22 (ubiquitin specific peptidase 22)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43796/usp22