USP24 (ubiquitin specific peptidase 24)

2014-08-01  

Identity

HGNC
LOCATION
1p32.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 23358
MIM: 610569
HGNC: 12623
Ensembl: ENSG00000162402

Variants:

dbSNP: 23358
ClinVar: 23358
TCGA: ENSG00000162402
COSMIC: USP24

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162402ENST00000294383Q9UPU5
ENSG00000162402ENST00000484447A0A0U1RQI9
ENSG00000162402ENST00000634589A0A0U1RRH2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258145332015Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.39
231598512012The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.23
169179322006Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease.21
169179322006Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease.21
255787272015The deubiquitinating enzyme USP24 is a regulator of the UV damage response.16
203028552010Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.10
203028552010Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.10
302668972018USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy.8
279919322017EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis.6
242866192014Transcriptional regulation of human USP24 gene expression by NF-kappa B.5

Citation

Dessen P

USP24 (ubiquitin specific peptidase 24)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54759/usp24