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USP25 (ubiquitin specific peptidase 25)

Identity

Alias_namesubiquitin specific protease 25
Alias_symbol (synonym)USP21
Other alias
HGNC (Hugo) USP25
LocusID (NCBI) 29761
Atlas_Id 429
Location 21q21.1  [Link to chromosome band 21q21]
Location_base_pair Starts at 17102344 and ends at 17252390 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ESR1 (6q25.1) / USP25 (21q21.1)RUNX1 (21q22.12) / USP25 (21q21.1)SND1 (7q32.1) / USP25 (21q21.1)
USP25 (21q21.1) / PCNT (21q22.3)USP25 (21q21.1) / TRAPPC10 (21q22.3)ESR1 6q25.1 / USP25 21q21.1
USP25 21q21.1 / PCNT 21q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP25   12624
Cards
Entrez_Gene (NCBI)USP25  29761  ubiquitin specific peptidase 25
AliasesUSP21
GeneCards (Weizmann)USP25
Ensembl hg19 (Hinxton)ENSG00000155313 [Gene_View]  chr21:17102344-17252390 [Contig_View]  USP25 [Vega]
Ensembl hg38 (Hinxton)ENSG00000155313 [Gene_View]  chr21:17102344-17252390 [Contig_View]  USP25 [Vega]
ICGC DataPortalENSG00000155313
TCGA cBioPortalUSP25
AceView (NCBI)USP25
Genatlas (Paris)USP25
WikiGenes29761
SOURCE (Princeton)USP25
Genetics Home Reference (NIH)USP25
Genomic and cartography
GoldenPath hg19 (UCSC)USP25  -     chr21:17102344-17252390 +  21q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)USP25  -     21q21.1   [Description]    (hg38-Dec_2013)
EnsemblUSP25 - 21q21.1 [CytoView hg19]  USP25 - 21q21.1 [CytoView hg38]
Mapping of homologs : NCBIUSP25 [Mapview hg19]  USP25 [Mapview hg38]
OMIM604736   
Gene and transcription
Genbank (Entrez)AF134213 AF170562 AK022447 AK022574 AK094083
RefSeq transcript (Entrez)NM_001283041 NM_001283042 NM_013396
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929426
Consensus coding sequences : CCDS (NCBI)USP25
Cluster EST : UnigeneHs.743994 [ NCBI ]
CGAP (NCI)Hs.743994
Alternative Splicing GalleryENSG00000155313
Gene ExpressionUSP25 [ NCBI-GEO ]   USP25 [ EBI - ARRAY_EXPRESS ]   USP25 [ SEEK ]   USP25 [ MEM ]
Gene Expression Viewer (FireBrowse)USP25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29761
GTEX Portal (Tissue expression)USP25
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHP3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHP3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHP3
Splice isoforms : SwissVarQ9UHP3
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ9UHP3
Domaine pattern : Prosite (Expaxy)UIM (PS50330)    USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    UBA-like    UIM_dom    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)    UIM (PF02809)   
Domain families : Pfam (NCBI)pfam00443    pfam02809   
Domain families : Smart (EMBL)UIM (SM00726)  
Conserved Domain (NCBI)USP25
DMDM Disease mutations29761
Blocks (Seattle)USP25
SuperfamilyQ9UHP3
Human Protein AtlasENSG00000155313
Peptide AtlasQ9UHP3
HPRD05296
IPIIPI00300439   IPI00219886   IPI00791721   IPI00059779   IPI00791051   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHP3
IntAct (EBI)Q9UHP3
FunCoupENSG00000155313
BioGRIDUSP25
STRING (EMBL)USP25
ZODIACUSP25
Ontologies - Pathways
QuickGOQ9UHP3
Ontology : AmiGOthiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  endoplasmic reticulum  cellular protein modification process  proteolysis  ubiquitin-dependent protein catabolic process  peptidase activity  protein deubiquitination  ubiquitin protein ligase binding  SUMO binding  ubiquitin binding  ATPase binding  protein K63-linked deubiquitination  protein K48-linked deubiquitination  negative regulation of ERAD pathway  ubiquitin-specific protease activity involved in negative regulation of ERAD pathway  
Ontology : EGO-EBIthiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  endoplasmic reticulum  cellular protein modification process  proteolysis  ubiquitin-dependent protein catabolic process  peptidase activity  protein deubiquitination  ubiquitin protein ligase binding  SUMO binding  ubiquitin binding  ATPase binding  protein K63-linked deubiquitination  protein K48-linked deubiquitination  negative regulation of ERAD pathway  ubiquitin-specific protease activity involved in negative regulation of ERAD pathway  
NDEx NetworkUSP25
Atlas of Cancer Signalling NetworkUSP25
Wikipedia pathwaysUSP25
Orthology - Evolution
OrthoDB29761
GeneTree (enSembl)ENSG00000155313
Phylogenetic Trees/Animal Genes : TreeFamUSP25
HOVERGENQ9UHP3
HOGENOMQ9UHP3
Homologs : HomoloGeneUSP25
Homology/Alignments : Family Browser (UCSC)USP25
Gene fusions - Rearrangements
Fusion : MitelmanESR1/USP25 [6q25.1/21q21.1]  [t(6;21)(q25;q21)]  
Fusion : MitelmanUSP25/PCNT [21q21.1/21q22.3]  [t(21;21)(q21;q22)]  
Fusion : MitelmanUSP25/TRAPPC10 [21q21.1/21q22.3]  [t(21;21)(q21;q22)]  
Fusion: TCGAESR1 6q25.1 USP25 21q21.1 BRCA
Fusion: TCGAUSP25 21q21.1 PCNT 21q22.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP25
dbVarUSP25
ClinVarUSP25
1000_GenomesUSP25 
Exome Variant ServerUSP25
ExAC (Exome Aggregation Consortium)USP25 (select the gene name)
Genetic variants : HAPMAP29761
Genomic Variants (DGV)USP25 [DGVbeta]
DECIPHER (Syndromes)21:17102344-17252390  ENSG00000155313
CONAN: Copy Number AnalysisUSP25 
Mutations
ICGC Data PortalUSP25 
TCGA Data PortalUSP25 
Broad Tumor PortalUSP25
OASIS PortalUSP25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP25
DgiDB (Drug Gene Interaction Database)USP25
DoCM (Curated mutations)USP25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP25 (select a term)
intoGenUSP25
Cancer3DUSP25(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604736   
Orphanet
MedgenUSP25
Genetic Testing Registry USP25
NextProtQ9UHP3 [Medical]
TSGene29761
GENETestsUSP25
Huge Navigator USP25 [HugePedia]
snp3D : Map Gene to Disease29761
BioCentury BCIQUSP25
ClinGenUSP25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29761
Chemical/Pharm GKB GenePA37249
Clinical trialUSP25
Miscellaneous
canSAR (ICR)USP25 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP25
EVEXUSP25
GoPubMedUSP25
iHOPUSP25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:33:36 CET 2017

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