USP26 (ubiquitin specific peptidase 26)

2017-08-01 Affiliation

Identity

HGNC

USP26

LOCATION

Xq26.2

LOCUSID

83844

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 83844
MIM: 300309
HGNC: 13485
Ensembl: ENSG00000134588

Variants:

dbSNP: 83844
ClinVar: 83844
TCGA: ENSG00000134588
COSMIC: USP26

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134588	ENST00000370832	Q9BXU7
ENSG00000134588	ENST00000511190	Q9BXU7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Deubiquitination	REACTOME	R-HSA-5688426
Ub-specific processing proteases	REACTOME	R-HSA-5689880

References

Pubmed ID	Year	Title	Citations
18062861	2007	Gene polymorphisms and male infertility--a meta-analysis and literature review.	58
20378615	2010	Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.	40
20501646	2010	The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.	32
15562280	2005	Possible role of USP26 in patients with severely impaired spermatogenesis.	22
15562280	2005	Possible role of USP26 in patients with severely impaired spermatogenesis.	22
17968467	2007	Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility.	19
17968467	2007	Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility.	19
15970005	2005	Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism.	16
15970005	2005	Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism.	16
28381482	2017	USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7.	13

Citation

Dessen P

USP26 (ubiquitin specific peptidase 26)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57046/usp26