USP27X (ubiquitin specific peptidase 27 X-linked)

2017-10-01  

Identity

HGNC
USP27X
LOCATION
Xp11.23
LOCUSID
389856
ALIAS
MRX105,USP22L,USP27

Other Information

Locus ID:

NCBI: 389856
MIM: 300975
HGNC: 13486
Ensembl: ENSG00000273820

Variants:

dbSNP: 389856
ClinVar: 389856
TCGA: ENSG00000273820
COSMIC: USP27X

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000273820ENST00000621775A6NNY8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
271329402016ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.29
315340082019Cutting Edge: USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA-Mediated Signaling.1
270134952016The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.0
294971242018USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis.0
303410662019TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1.0
320277332020USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I.0

Citation

Dessen P

USP27X (ubiquitin specific peptidase 27 X-linked)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57107/usp27x