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USP28 (ubiquitin specific peptidase 28)

Identity

Alias_namesubiquitin specific protease 28
Alias_symbol (synonym)KIAA1515
Other alias-
HGNC (Hugo) USP28
LocusID (NCBI) 57646
Atlas_Id 49733
Location 11q23.2  [Link to chromosome band 11q23]
Location_base_pair Starts at 113797875 and ends at 113875570 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PAFAH1B2 (11q23.3) / USP28 (11q23.2)PELI2 (14q22.3) / USP28 (11q23.2)SKIV2L2 (5q11.2) / USP28 (11q23.2)
USP28 (11q23.2) / DLG2 (11q14.1)SKIV2L2 5q11.2 / USP28 11q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP28   12625
Cards
Entrez_Gene (NCBI)USP28  57646  ubiquitin specific peptidase 28
Aliases
GeneCards (Weizmann)USP28
Ensembl hg19 (Hinxton)ENSG00000048028 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000048028 [Gene_View]  chr11:113797875-113875570 [Contig_View]  USP28 [Vega]
ICGC DataPortalENSG00000048028
TCGA cBioPortalUSP28
AceView (NCBI)USP28
Genatlas (Paris)USP28
WikiGenes57646
SOURCE (Princeton)USP28
Genetics Home Reference (NIH)USP28
Genomic and cartography
GoldenPath hg38 (UCSC)USP28  -     chr11:113797875-113875570 -  11q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP28  -     11q23.2   [Description]    (hg19-Feb_2009)
EnsemblUSP28 - 11q23.2 [CytoView hg19]  USP28 - 11q23.2 [CytoView hg38]
Mapping of homologs : NCBIUSP28 [Mapview hg19]  USP28 [Mapview hg38]
OMIM610748   
Gene and transcription
Genbank (Entrez)AB040948 AF266283 AK027521 AK097623 AK304376
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP28
Cluster EST : UnigeneHs.503891 [ NCBI ]
CGAP (NCI)Hs.503891
Alternative Splicing GalleryENSG00000048028
Gene ExpressionUSP28 [ NCBI-GEO ]   USP28 [ EBI - ARRAY_EXPRESS ]   USP28 [ SEEK ]   USP28 [ MEM ]
Gene Expression Viewer (FireBrowse)USP28 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57646
GTEX Portal (Tissue expression)USP28
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RU2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RU2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RU2
Splice isoforms : SwissVarQ96RU2
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ96RU2
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    UBA-like    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP28
DMDM Disease mutations57646
Blocks (Seattle)USP28
PDB (SRS)2LVA    2MUU   
PDB (PDBSum)2LVA    2MUU   
PDB (IMB)2LVA    2MUU   
PDB (RSDB)2LVA    2MUU   
Structural Biology KnowledgeBase2LVA    2MUU   
SCOP (Structural Classification of Proteins)2LVA    2MUU   
CATH (Classification of proteins structures)2LVA    2MUU   
SuperfamilyQ96RU2
Human Protein AtlasENSG00000048028
Peptide AtlasQ96RU2
HPRD15632
IPIIPI00045496   IPI00103951   IPI01010479   IPI01009333   IPI01014907   IPI01010049   IPI01015583   IPI01013069   IPI01013469   IPI01014203   IPI01013105   IPI01011633   IPI01013753   
Protein Interaction databases
DIP (DOE-UCLA)Q96RU2
IntAct (EBI)Q96RU2
FunCoupENSG00000048028
BioGRIDUSP28
STRING (EMBL)USP28
ZODIACUSP28
Ontologies - Pathways
QuickGOQ96RU2
Ontology : AmiGODNA damage checkpoint  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  nucleoplasm  DNA repair  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  Ras protein signal transduction  cell proliferation  response to ionizing radiation  protein deubiquitination  protein deubiquitination  protein deubiquitination  nuclear body  regulation of protein stability  cellular response to UV  thiol-dependent ubiquitinyl hydrolase activity  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  protein complex  
Ontology : EGO-EBIDNA damage checkpoint  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  nucleoplasm  DNA repair  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  Ras protein signal transduction  cell proliferation  response to ionizing radiation  protein deubiquitination  protein deubiquitination  protein deubiquitination  nuclear body  regulation of protein stability  cellular response to UV  thiol-dependent ubiquitinyl hydrolase activity  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  protein complex  
NDEx NetworkUSP28
Atlas of Cancer Signalling NetworkUSP28
Wikipedia pathwaysUSP28
Orthology - Evolution
OrthoDB57646
GeneTree (enSembl)ENSG00000048028
Phylogenetic Trees/Animal Genes : TreeFamUSP28
HOVERGENQ96RU2
HOGENOMQ96RU2
Homologs : HomoloGeneUSP28
Homology/Alignments : Family Browser (UCSC)USP28
Gene fusions - Rearrangements
Fusion : MitelmanSKIV2L2/USP28 [5q11.2/11q23.2]  [t(5;11)(q11;q23)]  
Fusion: TCGASKIV2L2 5q11.2 USP28 11q23.2 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP28 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP28
dbVarUSP28
ClinVarUSP28
1000_GenomesUSP28 
Exome Variant ServerUSP28
ExAC (Exome Aggregation Consortium)USP28 (select the gene name)
Genetic variants : HAPMAP57646
Genomic Variants (DGV)USP28 [DGVbeta]
DECIPHERUSP28 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP28 
Mutations
ICGC Data PortalUSP28 
TCGA Data PortalUSP28 
Broad Tumor PortalUSP28
OASIS PortalUSP28 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP28  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP28
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP28
DgiDB (Drug Gene Interaction Database)USP28
DoCM (Curated mutations)USP28 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP28 (select a term)
intoGenUSP28
Cancer3DUSP28(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610748   
Orphanet
MedgenUSP28
Genetic Testing Registry USP28
NextProtQ96RU2 [Medical]
TSGene57646
GENETestsUSP28
Target ValidationUSP28
Huge Navigator USP28 [HugePedia]
snp3D : Map Gene to Disease57646
BioCentury BCIQUSP28
ClinGenUSP28
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57646
Chemical/Pharm GKB GenePA37250
Clinical trialUSP28
Miscellaneous
canSAR (ICR)USP28 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP28
EVEXUSP28
GoPubMedUSP28
iHOPUSP28
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:02:11 CEST 2017

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