USP3 (ubiquitin specific peptidase 3)

2010-08-01 Affiliation

Identity

HGNC

USP3

LOCATION

15q22.31

LOCUSID

9960

ALIAS

SIH003,UBP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9960
MIM: 604728
HGNC: 12626
Ensembl: ENSG00000140455

Variants:

dbSNP: 9960
ClinVar: 9960
TCGA: ENSG00000140455
COSMIC: USP3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140455	ENST00000268049	Q6JHV3
ENSG00000140455	ENST00000380324	Q9Y6I4
ENSG00000140455	ENST00000540797	Q9Y6I4
ENSG00000140455	ENST00000557884	H0YNK1
ENSG00000140455	ENST00000558157	H0YNK1
ENSG00000140455	ENST00000558285	H0YMI4
ENSG00000140455	ENST00000559192	H0YLJ0
ENSG00000140455	ENST00000559257	H0YKU8
ENSG00000140455	ENST00000559276	H0YNX9
ENSG00000140455	ENST00000559711	H0YLB7
ENSG00000140455	ENST00000559771	H0YL81
ENSG00000140455	ENST00000559873	H0YMW1
ENSG00000140455	ENST00000560070	H0YLG0
ENSG00000140455	ENST00000560202	H0YM72
ENSG00000140455	ENST00000561442	H0YMP6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Deubiquitination	REACTOME	R-HSA-5688426
Ub-specific processing proteases	REACTOME	R-HSA-5689880

References

Pubmed ID	Year	Title	Citations
17980597	2007	Human USP3 is a chromatin modifier required for S phase progression and genome stability.	122
20445134	2010	Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.	73
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
24196443	2014	USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.	42
22743239	2012	UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.	9
28655924	2017	Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer.	7
30168892	2018	Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis.	6
28807825	2017	USP3 stabilizes p53 protein through its deubiquitinase activity.	5
31234902	2019	Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer.	5
31624151	2019	USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5.	1

Citation

Dessen P

USP3 (ubiquitin specific peptidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51611/usp3