USP33 (ubiquitin specific peptidase 33)

2009-10-01  

Identity

HGNC
LOCATION
1p31.1
LOCUSID
ALIAS
VDU1
FUSION GENES

Other Information

Locus ID:

NCBI: 23032
MIM: 615146
HGNC: 20059
Ensembl: ENSG00000077254

Variants:

dbSNP: 23032
ClinVar: 23032
TCGA: ENSG00000077254
COSMIC: USP33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077254ENST00000357428Q8TEY7
ENSG00000077254ENST00000370792Q8TEY7
ENSG00000077254ENST00000370793Q8TEY7
ENSG00000077254ENST00000370794Q8TEY7
ENSG00000077254ENST00000481579H0YCV3
ENSG00000077254ENST00000524536E9PQP0
ENSG00000077254ENST00000524778E9PP47
ENSG00000077254ENST00000527390H0YD08
ENSG00000077254ENST00000530709E9PLK7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
329721092023Downregulation of USP33 inhibits Slit/Robo signaling pathway and is associated with poor patient survival of glioma.2
370769922023USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells.0
329721092023Downregulation of USP33 inhibits Slit/Robo signaling pathway and is associated with poor patient survival of glioma.2
370769922023USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells.0
351915542022USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells.12
351915542022USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells.12
337926132021Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.12
339360862021SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia.48
344705812021Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma.2
337926132021Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.12
339360862021SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia.48
344705812021Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma.2
314327392020USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.40
328356982020USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma.11
314327392020USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.40

Citation

Dessen P

USP33 (ubiquitin specific peptidase 33)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51144/usp33