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USP35 (ubiquitin specific peptidase 35)

Identity

Alias (NCBI)-
HGNC (Hugo) USP35
HGNC Alias symbKIAA1372
HGNC Previous nameubiquitin specific protease 35
LocusID (NCBI) 57558
Atlas_Id 75558
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 78188812 and ends at 78215232 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARAP1 (11q13.4) / USP35 (11q14.1)USP35 (11q14.1) / ATAD3A (1p36.33)USP35 (11q14.1) / ATAD3B (1p36.33)
USP35 (11q14.1) / RNF169 (11q13.4)USP35 (11q14.1) / TSHZ2 (20q13.2)USP35 RNF169
USP35 TSHZ2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(11;11)(q13;q14) ARAP1/USP35
t(11;11)(q13;q14) USP35/RNF169
t(11;20)(q14;q13) USP35/TSHZ2

External links

Nomenclature
HGNC (Hugo)USP35   20061
Cards
Entrez_Gene (NCBI)USP35    ubiquitin specific peptidase 35
Aliases
GeneCards (Weizmann)USP35
Ensembl hg19 (Hinxton)ENSG00000118369 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118369 [Gene_View]  ENSG00000118369 [Sequence]  chr11:78188812-78215232 [Contig_View]  USP35 [Vega]
ICGC DataPortalENSG00000118369
TCGA cBioPortalUSP35
AceView (NCBI)USP35
Genatlas (Paris)USP35
SOURCE (Princeton)USP35
Genetics Home Reference (NIH)USP35
Genomic and cartography
GoldenPath hg38 (UCSC)USP35  -     chr11:78188812-78215232 +  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP35  -     11q14.1   [Description]    (hg19-Feb_2009)
GoldenPathUSP35 - 11q14.1 [CytoView hg19]  USP35 - 11q14.1 [CytoView hg38]
ImmunoBaseENSG00000118369
genome Data Viewer NCBIUSP35 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB037793 AI263341 AJ586137 AK056231 AK301048
RefSeq transcript (Entrez)NM_020798
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP35
Alternative Splicing GalleryENSG00000118369
Gene ExpressionUSP35 [ NCBI-GEO ]   USP35 [ EBI - ARRAY_EXPRESS ]   USP35 [ SEEK ]   USP35 [ MEM ]
Gene Expression Viewer (FireBrowse)USP35 [ Firebrowse - Broad ]
GenevisibleExpression of USP35 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57558
GTEX Portal (Tissue expression)USP35
Human Protein AtlasENSG00000118369-USP35 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2H5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2H5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2H5
Splice isoforms : SwissVarQ9P2H5
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9P2H5
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)ARM-type_fold    Papain-like_cys_pep_sf    Peptidase_C19_UCH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP35
Blocks (Seattle)USP35
PDB (RSDB)5TXK   
PDB Europe5TXK   
PDB (PDBSum)5TXK   
PDB (IMB)5TXK   
Structural Biology KnowledgeBase5TXK   
SCOP (Structural Classification of Proteins)5TXK   
CATH (Classification of proteins structures)5TXK   
SuperfamilyQ9P2H5
Human Protein Atlas [tissue]ENSG00000118369-USP35 [tissue]
Peptide AtlasQ9P2H5
IPIIPI00001726   IPI00973101   IPI00829926   IPI00983344   IPI00982832   IPI00985137   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2H5
IntAct (EBI)Q9P2H5
BioGRIDUSP35
STRING (EMBL)USP35
ZODIACUSP35
Ontologies - Pathways
QuickGOQ9P2H5
Ontology : AmiGOcysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein deubiquitination  
Ontology : EGO-EBIcysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein deubiquitination  
NDEx NetworkUSP35
Atlas of Cancer Signalling NetworkUSP35
Wikipedia pathwaysUSP35
Orthology - Evolution
OrthoDB57558
GeneTree (enSembl)ENSG00000118369
Phylogenetic Trees/Animal Genes : TreeFamUSP35
HOGENOMQ9P2H5
Homologs : HomoloGeneUSP35
Homology/Alignments : Family Browser (UCSC)USP35
Gene fusions - Rearrangements
Fusion PortalUSP35 RNF169
Fusion PortalUSP35 TSHZ2
Fusion : QuiverUSP35
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP35 [hg38]
dbVarUSP35
ClinVarUSP35
MonarchUSP35
1000_GenomesUSP35 
Exome Variant ServerUSP35
GNOMAD BrowserENSG00000118369
Varsome BrowserUSP35
Genomic Variants (DGV)USP35 [DGVbeta]
DECIPHERUSP35 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP35 
Mutations
ICGC Data PortalUSP35 
TCGA Data PortalUSP35 
Broad Tumor PortalUSP35
OASIS PortalUSP35 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP35  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUSP35
Mutations and Diseases : HGMDUSP35
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP35
DgiDB (Drug Gene Interaction Database)USP35
DoCM (Curated mutations)USP35 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP35 (select a term)
intoGenUSP35
Cancer3DUSP35(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETUSP35
MedgenUSP35
Genetic Testing Registry USP35
NextProtQ9P2H5 [Medical]
GENETestsUSP35
Target ValidationUSP35
Huge Navigator USP35 [HugePedia]
ClinGenUSP35
Clinical trials, drugs, therapy
MyCancerGenomeUSP35
Protein Interactions : CTD
Pharm GKB GenePA134883706
Clinical trialUSP35
Miscellaneous
canSAR (ICR)USP35 (select the gene name)
HarmonizomeUSP35
DataMed IndexUSP35
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP35
EVEXUSP35
GoPubMedUSP35
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:34:20 CET 2020
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