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USP37 (ubiquitin specific peptidase 37)

Identity

Alias_namesubiquitin specific protease 37
Alias_symbol (synonym)KIAA1594
Other alias-
HGNC (Hugo) USP37
LocusID (NCBI) 57695
Atlas_Id 54761
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218450251 and ends at 218568361 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ITGB4 (17q25.1) / USP37 (2q35)SAMD12 (8q24.12) / USP37 (2q35)USP37 (2q35) / OSMR (5p13.1)
USP37 (2q35) / RNF25 (2q35)USP37 (2q35) / SAMD12 (8q24.12)SAMD12 8q24.12 / USP37 2q35
USP37 2q35 / RNF25 2q35USP37 2q35 / SAMD12 8q24.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)USP37   20063
Cards
Entrez_Gene (NCBI)USP37  57695  ubiquitin specific peptidase 37
Aliases
GeneCards (Weizmann)USP37
Ensembl hg19 (Hinxton)ENSG00000135913 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135913 [Gene_View]  chr2:218450251-218568361 [Contig_View]  USP37 [Vega]
ICGC DataPortalENSG00000135913
TCGA cBioPortalUSP37
AceView (NCBI)USP37
Genatlas (Paris)USP37
WikiGenes57695
SOURCE (Princeton)USP37
Genetics Home Reference (NIH)USP37
Genomic and cartography
GoldenPath hg38 (UCSC)USP37  -     chr2:218450251-218568361 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP37  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblUSP37 - 2q35 [CytoView hg19]  USP37 - 2q35 [CytoView hg38]
Mapping of homologs : NCBIUSP37 [Mapview hg19]  USP37 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB046814 AK095577 AK128583 AL832645 AM392929
RefSeq transcript (Entrez)NM_020935
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP37
Cluster EST : UnigeneHs.166068 [ NCBI ]
CGAP (NCI)Hs.166068
Alternative Splicing GalleryENSG00000135913
Gene ExpressionUSP37 [ NCBI-GEO ]   USP37 [ EBI - ARRAY_EXPRESS ]   USP37 [ SEEK ]   USP37 [ MEM ]
Gene Expression Viewer (FireBrowse)USP37 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57695
GTEX Portal (Tissue expression)USP37
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86T82   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86T82  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86T82
Splice isoforms : SwissVarQ86T82
PhosPhoSitePlusQ86T82
Domaine pattern : Prosite (Expaxy)UIM (PS50330)    USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    UIM_dom    USP37-like_PH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)    UCH_N (PF16674)    UIM (PF02809)   
Domain families : Pfam (NCBI)pfam00443    pfam16674    pfam02809   
Domain families : Smart (EMBL)UIM (SM00726)  
Conserved Domain (NCBI)USP37
DMDM Disease mutations57695
Blocks (Seattle)USP37
PDB (SRS)3U12   
PDB (PDBSum)3U12   
PDB (IMB)3U12   
PDB (RSDB)3U12   
Structural Biology KnowledgeBase3U12   
SCOP (Structural Classification of Proteins)3U12   
CATH (Classification of proteins structures)3U12   
SuperfamilyQ86T82
Human Protein AtlasENSG00000135913
Peptide AtlasQ86T82
HPRD07506
IPIIPI00472977   IPI00925754   IPI00744442   
Protein Interaction databases
DIP (DOE-UCLA)Q86T82
IntAct (EBI)Q86T82
FunCoupENSG00000135913
BioGRIDUSP37
STRING (EMBL)USP37
ZODIACUSP37
Ontologies - Pathways
QuickGOQ86T82
Ontology : AmiGOG1/S transition of mitotic cell cycle  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  regulation of DNA replication  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein deubiquitination  protein deubiquitination  protein kinase binding  protein K11-linked deubiquitination  thiol-dependent ubiquitinyl hydrolase activity  cell division  protein K48-linked deubiquitination  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  regulation of DNA replication  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein deubiquitination  protein deubiquitination  protein kinase binding  protein K11-linked deubiquitination  thiol-dependent ubiquitinyl hydrolase activity  cell division  protein K48-linked deubiquitination  
NDEx NetworkUSP37
Atlas of Cancer Signalling NetworkUSP37
Wikipedia pathwaysUSP37
Orthology - Evolution
OrthoDB57695
GeneTree (enSembl)ENSG00000135913
Phylogenetic Trees/Animal Genes : TreeFamUSP37
HOVERGENQ86T82
HOGENOMQ86T82
Homologs : HomoloGeneUSP37
Homology/Alignments : Family Browser (UCSC)USP37
Gene fusions - Rearrangements
Fusion : MitelmanSAMD12/USP37 [8q24.12/2q35]  [t(2;8)(q35;q24)]  
Fusion : MitelmanUSP37/OSMR [2q35/5p13.1]  [t(2;5)(q35;p13)]  
Fusion : MitelmanUSP37/SAMD12 [2q35/8q24.12]  [t(2;8)(q35;q24)]  
Fusion: TCGASAMD12 8q24.12 USP37 2q35 BRCA
Fusion: TCGAUSP37 2q35 RNF25 2q35 BRCA
Fusion: TCGAUSP37 2q35 SAMD12 8q24.12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP37 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP37
dbVarUSP37
ClinVarUSP37
1000_GenomesUSP37 
Exome Variant ServerUSP37
ExAC (Exome Aggregation Consortium)USP37 (select the gene name)
Genetic variants : HAPMAP57695
Genomic Variants (DGV)USP37 [DGVbeta]
DECIPHERUSP37 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP37 
Mutations
ICGC Data PortalUSP37 
TCGA Data PortalUSP37 
Broad Tumor PortalUSP37
OASIS PortalUSP37 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP37  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP37
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP37
DgiDB (Drug Gene Interaction Database)USP37
DoCM (Curated mutations)USP37 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP37 (select a term)
intoGenUSP37
Cancer3DUSP37(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenUSP37
Genetic Testing Registry USP37
NextProtQ86T82 [Medical]
TSGene57695
GENETestsUSP37
Target ValidationUSP37
Huge Navigator USP37 [HugePedia]
snp3D : Map Gene to Disease57695
BioCentury BCIQUSP37
ClinGenUSP37
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57695
Chemical/Pharm GKB GenePA134928706
Clinical trialUSP37
Miscellaneous
canSAR (ICR)USP37 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP37
EVEXUSP37
GoPubMedUSP37
iHOPUSP37
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:18:32 CEST 2017

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