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USP4 (ubiquitin specific peptidase 4)

Identity

Alias_namesUNP
ubiquitin specific peptidase 4 (proto-oncogene)
Alias_symbol (synonym)Unph
Other alias
HGNC (Hugo) USP4
LocusID (NCBI) 7375
Atlas_Id 42771
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49311785 and ends at 49340103 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
USP4 (3p21.31) / C3orf62 (3p21.31)USP4 (3p21.31) / NEMF (14q21.3)USP4 (3p21.31) / RHOA (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP4   12627
Cards
Entrez_Gene (NCBI)USP4  7375  ubiquitin specific peptidase 4
AliasesUNP; Unph
GeneCards (Weizmann)USP4
Ensembl hg19 (Hinxton)ENSG00000114316 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114316 [Gene_View]  chr3:49311785-49340103 [Contig_View]  USP4 [Vega]
ICGC DataPortalENSG00000114316
TCGA cBioPortalUSP4
AceView (NCBI)USP4
Genatlas (Paris)USP4
WikiGenes7375
SOURCE (Princeton)USP4
Genetics Home Reference (NIH)USP4
Genomic and cartography
GoldenPath hg38 (UCSC)USP4  -     chr3:49311785-49340103 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP4  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblUSP4 - 3p21.31 [CytoView hg19]  USP4 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIUSP4 [Mapview hg19]  USP4 [Mapview hg38]
OMIM603486   
Gene and transcription
Genbank (Entrez)AF017305 AF017306 AI887410 AK127055 AK222725
RefSeq transcript (Entrez)NM_001251877 NM_003363 NM_199443
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP4
Cluster EST : UnigeneHs.403828 [ NCBI ]
CGAP (NCI)Hs.403828
Alternative Splicing GalleryENSG00000114316
Gene ExpressionUSP4 [ NCBI-GEO ]   USP4 [ EBI - ARRAY_EXPRESS ]   USP4 [ SEEK ]   USP4 [ MEM ]
Gene Expression Viewer (FireBrowse)USP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7375
GTEX Portal (Tissue expression)USP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13107   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13107  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13107
Splice isoforms : SwissVarQ13107
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ13107
Domaine pattern : Prosite (Expaxy)DUSP (PS51283)    USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Pept_C19_DUSP    Peptidase_C19_UCH    Ub_USP-typ    USP_CS    USP_dom   
Domain families : Pfam (Sanger)DUSP (PF06337)    Ubiquitin_3 (PF14836)    UCH (PF00443)   
Domain families : Pfam (NCBI)pfam06337    pfam14836    pfam00443   
Domain families : Smart (EMBL)DUSP (SM00695)  
Conserved Domain (NCBI)USP4
DMDM Disease mutations7375
Blocks (Seattle)USP4
PDB (SRS)2Y6E    5CTR   
PDB (PDBSum)2Y6E    5CTR   
PDB (IMB)2Y6E    5CTR   
PDB (RSDB)2Y6E    5CTR   
Structural Biology KnowledgeBase2Y6E    5CTR   
SCOP (Structural Classification of Proteins)2Y6E    5CTR   
CATH (Classification of proteins structures)2Y6E    5CTR   
SuperfamilyQ13107
Human Protein AtlasENSG00000114316
Peptide AtlasQ13107
HPRD04598
IPIIPI00011836   IPI00216257   IPI00924599   IPI00927927   IPI00927620   
Protein Interaction databases
DIP (DOE-UCLA)Q13107
IntAct (EBI)Q13107
FunCoupENSG00000114316
BioGRIDUSP4
STRING (EMBL)USP4
ZODIACUSP4
Ontologies - Pathways
QuickGOQ13107
Ontology : AmiGOspliceosomal tri-snRNP complex assembly  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  lysosome  cytosol  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein deubiquitination  protein deubiquitination  negative regulation of protein ubiquitination  regulation of protein stability  adenosine receptor binding  protein localization to cell surface  thiol-dependent ubiquitinyl hydrolase activity  identical protein binding  metal ion binding  
Ontology : EGO-EBIspliceosomal tri-snRNP complex assembly  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  lysosome  cytosol  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein deubiquitination  protein deubiquitination  negative regulation of protein ubiquitination  regulation of protein stability  adenosine receptor binding  protein localization to cell surface  thiol-dependent ubiquitinyl hydrolase activity  identical protein binding  metal ion binding  
NDEx NetworkUSP4
Atlas of Cancer Signalling NetworkUSP4
Wikipedia pathwaysUSP4
Orthology - Evolution
OrthoDB7375
GeneTree (enSembl)ENSG00000114316
Phylogenetic Trees/Animal Genes : TreeFamUSP4
HOVERGENQ13107
HOGENOMQ13107
Homologs : HomoloGeneUSP4
Homology/Alignments : Family Browser (UCSC)USP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP4
dbVarUSP4
ClinVarUSP4
1000_GenomesUSP4 
Exome Variant ServerUSP4
ExAC (Exome Aggregation Consortium)USP4 (select the gene name)
Genetic variants : HAPMAP7375
Genomic Variants (DGV)USP4 [DGVbeta]
DECIPHERUSP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP4 
Mutations
ICGC Data PortalUSP4 
TCGA Data PortalUSP4 
Broad Tumor PortalUSP4
OASIS PortalUSP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP4
DgiDB (Drug Gene Interaction Database)USP4
DoCM (Curated mutations)USP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP4 (select a term)
intoGenUSP4
Cancer3DUSP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603486   
Orphanet
MedgenUSP4
Genetic Testing Registry USP4
NextProtQ13107 [Medical]
TSGene7375
GENETestsUSP4
Huge Navigator USP4 [HugePedia]
snp3D : Map Gene to Disease7375
BioCentury BCIQUSP4
ClinGenUSP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7375
Chemical/Pharm GKB GenePA37252
Clinical trialUSP4
Miscellaneous
canSAR (ICR)USP4 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP4
EVEXUSP4
GoPubMedUSP4
iHOPUSP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri May 19 12:43:35 CEST 2017

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