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USP42 (ubiquitin specific peptidase 42)

Identity

Alias_namesubiquitin specific protease 42
Alias_symbol (synonym)FLJ12697
Other alias-
HGNC (Hugo) USP42
LocusID (NCBI) 84132
Atlas_Id 42965
Location 7p22.1  [Link to chromosome band 7p22]
Location_base_pair Starts at 6104919 and ends at 6161564 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CREB5 (7p15.1) / USP42 (7p22.1)RUNX1 (21q22.12) / USP42 (7p22.1)USP42 (7p22.1) / GLCCI1 (7p21.3)
USP42 (7p22.1) / RUNX1 (21q22.12)USP42 (7p22.1) / SLC46A2 (9q32)USP42 (7p22.1) / USP42 (7p22.1)
CREB5 7p15.1 / USP42 7p22.1USP42 7p22.1 / GLCCI1 7p21.3USP42 7p22.1 / SLC46A2 9q32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;21)(p22;q22) RUNX1/USP42


External links

Nomenclature
HGNC (Hugo)USP42   20068
Cards
Entrez_Gene (NCBI)USP42  84132  ubiquitin specific peptidase 42
Aliases
GeneCards (Weizmann)USP42
Ensembl hg19 (Hinxton)ENSG00000106346 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106346 [Gene_View]  chr7:6104919-6161564 [Contig_View]  USP42 [Vega]
ICGC DataPortalENSG00000106346
TCGA cBioPortalUSP42
AceView (NCBI)USP42
Genatlas (Paris)USP42
WikiGenes84132
SOURCE (Princeton)USP42
Genetics Home Reference (NIH)USP42
Genomic and cartography
GoldenPath hg38 (UCSC)USP42  -     chr7:6104919-6161564 +  7p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP42  -     7p22.1   [Description]    (hg19-Feb_2009)
EnsemblUSP42 - 7p22.1 [CytoView hg19]  USP42 - 7p22.1 [CytoView hg38]
Mapping of homologs : NCBIUSP42 [Mapview hg19]  USP42 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA936550 AJ601395 AK022759 AK298164 AK301527
RefSeq transcript (Entrez)NM_032172
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP42
Cluster EST : UnigeneHs.31856 [ NCBI ]
CGAP (NCI)Hs.31856
Alternative Splicing GalleryENSG00000106346
Gene ExpressionUSP42 [ NCBI-GEO ]   USP42 [ EBI - ARRAY_EXPRESS ]   USP42 [ SEEK ]   USP42 [ MEM ]
Gene Expression Viewer (FireBrowse)USP42 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84132
GTEX Portal (Tissue expression)USP42
Human Protein AtlasENSG00000106346-USP42 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9J4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9J4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9J4
Splice isoforms : SwissVarQ9H9J4
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ9H9J4
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP42
DMDM Disease mutations84132
Blocks (Seattle)USP42
SuperfamilyQ9H9J4
Human Protein Atlas [tissue]ENSG00000106346-USP42 [tissue]
Peptide AtlasQ9H9J4
IPIIPI01009873   IPI00784612   IPI00908738   IPI00892701   IPI00978666   IPI00976770   IPI01011330   IPI01012580   
Protein Interaction databases
DIP (DOE-UCLA)Q9H9J4
IntAct (EBI)Q9H9J4
FunCoupENSG00000106346
BioGRIDUSP42
STRING (EMBL)USP42
ZODIACUSP42
Ontologies - Pathways
QuickGOQ9H9J4
Ontology : AmiGOthiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  ubiquitin-dependent protein catabolic process  spermatogenesis  protein deubiquitination  protein deubiquitination  protein deubiquitination  cell differentiation  thiol-dependent ubiquitinyl hydrolase activity  
Ontology : EGO-EBIthiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  ubiquitin-dependent protein catabolic process  spermatogenesis  protein deubiquitination  protein deubiquitination  protein deubiquitination  cell differentiation  thiol-dependent ubiquitinyl hydrolase activity  
NDEx NetworkUSP42
Atlas of Cancer Signalling NetworkUSP42
Wikipedia pathwaysUSP42
Orthology - Evolution
OrthoDB84132
GeneTree (enSembl)ENSG00000106346
Phylogenetic Trees/Animal Genes : TreeFamUSP42
HOVERGENQ9H9J4
HOGENOMQ9H9J4
Homologs : HomoloGeneUSP42
Homology/Alignments : Family Browser (UCSC)USP42
Gene fusions - Rearrangements
Fusion : MitelmanCREB5/USP42 [7p15.1/7p22.1]  [t(7;7)(p15;p22)]  
Fusion : MitelmanRUNX1/USP42 [21q22.12/7p22.1]  [t(7;21)(p22;q22)]  
Fusion : MitelmanUSP42/GLCCI1 [7p22.1/7p21.3]  [t(7;7)(p21;p22)]  
Fusion : MitelmanUSP42/SLC46A2 [7p22.1/9q32]  [t(7;9)(p22;q32)]  
Fusion: TCGA_MDACCCREB5 7p15.1 USP42 7p22.1 BRCA
Fusion: TCGA_MDACCUSP42 7p22.1 GLCCI1 7p21.3 BRCA
Fusion: TCGA_MDACCUSP42 7p22.1 SLC46A2 9q32 BRCA
Tumor Fusion PortalUSP42
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP42 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP42
dbVarUSP42
ClinVarUSP42
1000_GenomesUSP42 
Exome Variant ServerUSP42
ExAC (Exome Aggregation Consortium)ENSG00000106346
GNOMAD BrowserENSG00000106346
Genetic variants : HAPMAP84132
Genomic Variants (DGV)USP42 [DGVbeta]
DECIPHERUSP42 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP42 
Mutations
ICGC Data PortalUSP42 
TCGA Data PortalUSP42 
Broad Tumor PortalUSP42
OASIS PortalUSP42 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDUSP42
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP42
DgiDB (Drug Gene Interaction Database)USP42
DoCM (Curated mutations)USP42 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP42 (select a term)
intoGenUSP42
Cancer3DUSP42(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETUSP42
MedgenUSP42
Genetic Testing Registry USP42
NextProtQ9H9J4 [Medical]
TSGene84132
GENETestsUSP42
Target ValidationUSP42
Huge Navigator USP42 [HugePedia]
snp3D : Map Gene to Disease84132
BioCentury BCIQUSP42
ClinGenUSP42
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84132
Chemical/Pharm GKB GenePA134902515
Clinical trialUSP42
Miscellaneous
canSAR (ICR)USP42 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP42
EVEXUSP42
GoPubMedUSP42
iHOPUSP42
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:41:05 CET 2017

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