USP44 (ubiquitin specific peptidase 44)

2012-01-01  

Identity

HGNC
USP44
LOCATION
12q22
LOCUSID
84101
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84101
MIM: 610993
HGNC: 20064
Ensembl: ENSG00000136014

Variants:

dbSNP: 84101
ClinVar: 84101
TCGA: ENSG00000136014
COSMIC: USP44

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136014ENST00000258499Q9H0E7
ENSG00000136014ENST00000258499A0A024RBD7
ENSG00000136014ENST00000393091Q9H0E7
ENSG00000136014ENST00000393091A0A024RBD7
ENSG00000136014ENST00000537435Q9H0E7
ENSG00000136014ENST00000537435A0A024RBD7
ENSG00000136014ENST00000549639F8VVD6
ENSG00000136014ENST00000551837F8VRW0
ENSG00000136014ENST00000552440F8VRI7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

References

Pubmed IDYearTitleCitations
174431802007Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.163
236159622013The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases.49
218531242011Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.26
226925372012Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit.22
262324242015USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry.22
278809112016USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.15
248370382014Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.10
285447032017High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer.6
306222302019USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.3
311979572019Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer.3

Citation

Dessen P

USP44 (ubiquitin specific peptidase 44)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52539/usp44