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USP46 (ubiquitin specific peptidase 46)

Identity

Alias_namesubiquitin specific protease 46
Alias_symbol (synonym)FLJ12552
Other alias-
HGNC (Hugo) USP46
LocusID (NCBI) 64854
Atlas_Id 54763
Location 4q12  [Link to chromosome band 4q12]
Location_base_pair Starts at 53457127 and ends at 53522759 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KMT2A (11q23.3) / USP46 (4q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP46   20075
Cards
Entrez_Gene (NCBI)USP46  64854  ubiquitin specific peptidase 46
Aliases
GeneCards (Weizmann)USP46
Ensembl hg19 (Hinxton)ENSG00000109189 [Gene_View]  chr4:53457127-53522759 [Contig_View]  USP46 [Vega]
Ensembl hg38 (Hinxton)ENSG00000109189 [Gene_View]  chr4:53457127-53522759 [Contig_View]  USP46 [Vega]
ICGC DataPortalENSG00000109189
TCGA cBioPortalUSP46
AceView (NCBI)USP46
Genatlas (Paris)USP46
WikiGenes64854
SOURCE (Princeton)USP46
Genetics Home Reference (NIH)USP46
Genomic and cartography
GoldenPath hg19 (UCSC)USP46  -     chr4:53457127-53522759 -  4q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)USP46  -     4q12   [Description]    (hg38-Dec_2013)
EnsemblUSP46 - 4q12 [CytoView hg19]  USP46 - 4q12 [CytoView hg38]
Mapping of homologs : NCBIUSP46 [Mapview hg19]  USP46 [Mapview hg38]
OMIM612849   
Gene and transcription
Genbank (Entrez)AF070557 AK021861 AK021912 AK022614 AK024318
RefSeq transcript (Entrez)NM_001134223 NM_001286767 NM_001286768 NM_022832
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_022853 NW_004929319
Consensus coding sequences : CCDS (NCBI)USP46
Cluster EST : UnigeneHs.7966 [ NCBI ]
CGAP (NCI)Hs.7966
Alternative Splicing GalleryENSG00000109189
Gene ExpressionUSP46 [ NCBI-GEO ]   USP46 [ EBI - ARRAY_EXPRESS ]   USP46 [ SEEK ]   USP46 [ MEM ]
Gene Expression Viewer (FireBrowse)USP46 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64854
GTEX Portal (Tissue expression)USP46
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62068   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62068  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62068
Splice isoforms : SwissVarP62068
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusP62068
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP46
DMDM Disease mutations64854
Blocks (Seattle)USP46
PDB (SRS)5CVM    5CVN    5CVO   
PDB (PDBSum)5CVM    5CVN    5CVO   
PDB (IMB)5CVM    5CVN    5CVO   
PDB (RSDB)5CVM    5CVN    5CVO   
Structural Biology KnowledgeBase5CVM    5CVN    5CVO   
SCOP (Structural Classification of Proteins)5CVM    5CVN    5CVO   
CATH (Classification of proteins structures)5CVM    5CVN    5CVO   
SuperfamilyP62068
Human Protein AtlasENSG00000109189
Peptide AtlasP62068
HPRD07507
IPIIPI00303458   IPI00909695   IPI00936274   IPI00966808   IPI00935919   IPI00965377   
Protein Interaction databases
DIP (DOE-UCLA)P62068
IntAct (EBI)P62068
FunCoupENSG00000109189
BioGRIDUSP46
STRING (EMBL)USP46
ZODIACUSP46
Ontologies - Pathways
QuickGOP62068
Ontology : AmiGObehavioral fear response  thiol-dependent ubiquitin-specific protease activity  protein binding  ubiquitin-dependent protein catabolic process  adult feeding behavior  protein deubiquitination  regulation of synaptic transmission, GABAergic  behavioral response to ethanol  righting reflex  
Ontology : EGO-EBIbehavioral fear response  thiol-dependent ubiquitin-specific protease activity  protein binding  ubiquitin-dependent protein catabolic process  adult feeding behavior  protein deubiquitination  regulation of synaptic transmission, GABAergic  behavioral response to ethanol  righting reflex  
NDEx NetworkUSP46
Atlas of Cancer Signalling NetworkUSP46
Wikipedia pathwaysUSP46
Orthology - Evolution
OrthoDB64854
GeneTree (enSembl)ENSG00000109189
Phylogenetic Trees/Animal Genes : TreeFamUSP46
HOVERGENP62068
HOGENOMP62068
Homologs : HomoloGeneUSP46
Homology/Alignments : Family Browser (UCSC)USP46
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP46 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP46
dbVarUSP46
ClinVarUSP46
1000_GenomesUSP46 
Exome Variant ServerUSP46
ExAC (Exome Aggregation Consortium)USP46 (select the gene name)
Genetic variants : HAPMAP64854
Genomic Variants (DGV)USP46 [DGVbeta]
DECIPHER (Syndromes)4:53457127-53522759  ENSG00000109189
CONAN: Copy Number AnalysisUSP46 
Mutations
ICGC Data PortalUSP46 
TCGA Data PortalUSP46 
Broad Tumor PortalUSP46
OASIS PortalUSP46 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP46  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP46
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP46
DgiDB (Drug Gene Interaction Database)USP46
DoCM (Curated mutations)USP46 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP46 (select a term)
intoGenUSP46
Cancer3DUSP46(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612849   
Orphanet
MedgenUSP46
Genetic Testing Registry USP46
NextProtP62068 [Medical]
TSGene64854
GENETestsUSP46
Huge Navigator USP46 [HugePedia]
snp3D : Map Gene to Disease64854
BioCentury BCIQUSP46
ClinGenUSP46
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64854
Chemical/Pharm GKB GenePA134922048
Clinical trialUSP46
Miscellaneous
canSAR (ICR)USP46 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP46
EVEXUSP46
GoPubMedUSP46
iHOPUSP46
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:35 CEST 2017

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