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USP49 (ubiquitin specific peptidase 49)

Identity

Alias_namesubiquitin specific protease 49
Alias_symbol (synonym)MGC20741
Other alias-
HGNC (Hugo) USP49
LocusID (NCBI) 25862
Atlas_Id 75566
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 41789896 and ends at 41871637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD2AP (6p12.3) / USP49 (6p21.1)MED20 (6p21.1) / USP49 (6p21.1)USP49 (6p21.1) / DAAM2 (6p21.2)
USP49 (6p21.1) / KCTD20 (6p21.31)USP49 (6p21.1) / MED20 (6p21.1)USP49 (6p21.1) / STRN (2p22.2)
USP49 (6p21.1) / TAF8 (6p21.1)USP49 MED20USP49 STRN
USP49 DAAM2USP49 KCTD20USP49 TAF8

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(2;6)(p22;p21) USP49/STRN
t(6;6)(p12;p21) CD2AP/USP49
t(6;6)(p21;p21) USP49/DAAM2
t(6;6)(p21;p21) USP49/KCTD20
t(6;6)(p21;p21) USP49/MED20
t(6;6)(p21;p21) USP49/TAF8


External links

Nomenclature
HGNC (Hugo)USP49   20078
Cards
Entrez_Gene (NCBI)USP49  25862  ubiquitin specific peptidase 49
Aliases
GeneCards (Weizmann)USP49
Ensembl hg19 (Hinxton)ENSG00000164663 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164663 [Gene_View]  ENSG00000164663 [Sequence]  chr6:41789896-41871637 [Contig_View]  USP49 [Vega]
ICGC DataPortalENSG00000164663
TCGA cBioPortalUSP49
AceView (NCBI)USP49
Genatlas (Paris)USP49
WikiGenes25862
SOURCE (Princeton)USP49
Genetics Home Reference (NIH)USP49
Genomic and cartography
GoldenPath hg38 (UCSC)USP49  -     chr6:41789896-41871637 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP49  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblUSP49 - 6p21.1 [CytoView hg19]  USP49 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIUSP49 [Mapview hg19]  USP49 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AJ586139 AK023682 AL110255 BC014176 BU631853
RefSeq transcript (Entrez)NM_001286554 NM_018561
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP49
Cluster EST : UnigeneHs.665742 [ NCBI ]
CGAP (NCI)Hs.665742
Alternative Splicing GalleryENSG00000164663
Gene ExpressionUSP49 [ NCBI-GEO ]   USP49 [ EBI - ARRAY_EXPRESS ]   USP49 [ SEEK ]   USP49 [ MEM ]
Gene Expression Viewer (FireBrowse)USP49 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25862
GTEX Portal (Tissue expression)USP49
Human Protein AtlasENSG00000164663-USP49 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ70CQ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ70CQ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ70CQ1
Splice isoforms : SwissVarQ70CQ1
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ70CQ1
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)    ZF_UBP (PS50271)   
Domains : Interpro (EBI)Peptidase_C19_UCH    USP_CS    USP_dom    Znf_RING/FYVE/PHD    Znf_UBP   
Domain families : Pfam (Sanger)UCH (PF00443)    zf-UBP (PF02148)   
Domain families : Pfam (NCBI)pfam00443    pfam02148   
Domain families : Smart (EMBL)ZnF_UBP (SM00290)  
Conserved Domain (NCBI)USP49
DMDM Disease mutations25862
Blocks (Seattle)USP49
SuperfamilyQ70CQ1
Human Protein Atlas [tissue]ENSG00000164663-USP49 [tissue]
Peptide AtlasQ70CQ1
HPRD10075
IPIIPI00455818   IPI00156871   IPI00639902   IPI00853604   IPI00853538   IPI00892729   
Protein Interaction databases
DIP (DOE-UCLA)Q70CQ1
IntAct (EBI)Q70CQ1
FunCoupENSG00000164663
BioGRIDUSP49
STRING (EMBL)USP49
ZODIACUSP49
Ontologies - Pathways
QuickGOQ70CQ1
Ontology : AmiGO###############################################################################################################################################################################################################################################################                        
Ontology : EGO-EBI###############################################################################################################################################################################################################################################################                        
NDEx NetworkUSP49
Atlas of Cancer Signalling NetworkUSP49
Wikipedia pathwaysUSP49
Orthology - Evolution
OrthoDB25862
GeneTree (enSembl)ENSG00000164663
Phylogenetic Trees/Animal Genes : TreeFamUSP49
HOVERGENQ70CQ1
HOGENOMQ70CQ1
Homologs : HomoloGeneUSP49
Homology/Alignments : Family Browser (UCSC)USP49
Gene fusions - Rearrangements
Fusion PortalUSP49 MED20
Fusion PortalUSP49 STRN
Fusion PortalUSP49 DAAM2
Fusion PortalUSP49 KCTD20
Fusion PortalUSP49 TAF8
Fusion : QuiverUSP49
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP49 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP49
dbVarUSP49
ClinVarUSP49
1000_GenomesUSP49 
Exome Variant ServerUSP49
ExAC (Exome Aggregation Consortium)ENSG00000164663
GNOMAD BrowserENSG00000164663
Varsome BrowserUSP49
Genetic variants : HAPMAP25862
Genomic Variants (DGV)USP49 [DGVbeta]
DECIPHERUSP49 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP49 
Mutations
ICGC Data PortalUSP49 
TCGA Data PortalUSP49 
Broad Tumor PortalUSP49
OASIS PortalUSP49 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP49  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP49
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP49
DgiDB (Drug Gene Interaction Database)USP49
DoCM (Curated mutations)USP49 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP49 (select a term)
intoGenUSP49
Cancer3DUSP49(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETUSP49
MedgenUSP49
Genetic Testing Registry USP49
NextProtQ70CQ1 [Medical]
TSGene25862
GENETestsUSP49
Target ValidationUSP49
Huge Navigator USP49 [HugePedia]
snp3D : Map Gene to Disease25862
BioCentury BCIQUSP49
ClinGenUSP49
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25862
Chemical/Pharm GKB GenePA134954570
Clinical trialUSP49
Miscellaneous
canSAR (ICR)USP49 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP49
EVEXUSP49
GoPubMedUSP49
iHOPUSP49
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 30 14:37:54 CEST 2018

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