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USP5 (ubiquitin specific peptidase 5)

Identity

Alias_namesubiquitin specific peptidase 5 (isopeptidase T)
Alias_symbol (synonym)IsoT
Other aliasISOT
HGNC (Hugo) USP5
LocusID (NCBI) 8078
Atlas_Id 42772
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6852121 and ends at 6866631 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COQ10A (12q13.3) / USP5 (12p13.31)THRA (17q21.1) / USP5 (12p13.31)USP5 (12p13.31) / C6orf106 (6p21.31)
USP5 (12p13.31) / SLTM (15q22.1)USP5 (12p13.31) / SRSF4 (1p35.3)COQ10A 12q13.3 / USP5 12p13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)USP5   12628
Cards
Entrez_Gene (NCBI)USP5  8078  ubiquitin specific peptidase 5
AliasesISOT
GeneCards (Weizmann)USP5
Ensembl hg19 (Hinxton)ENSG00000111667 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111667 [Gene_View]  chr12:6852121-6866631 [Contig_View]  USP5 [Vega]
ICGC DataPortalENSG00000111667
TCGA cBioPortalUSP5
AceView (NCBI)USP5
Genatlas (Paris)USP5
WikiGenes8078
SOURCE (Princeton)USP5
Genetics Home Reference (NIH)USP5
Genomic and cartography
GoldenPath hg38 (UCSC)USP5  -     chr12:6852121-6866631 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP5  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblUSP5 - 12p13.31 [CytoView hg19]  USP5 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIUSP5 [Mapview hg19]  USP5 [Mapview hg38]
OMIM601447   
Gene and transcription
Genbank (Entrez)AI289395 AK308021 AU099996 BC004889 BC005139
RefSeq transcript (Entrez)NM_001098536 NM_003481
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP5
Cluster EST : UnigeneHs.631661 [ NCBI ]
CGAP (NCI)Hs.631661
Alternative Splicing GalleryENSG00000111667
Gene ExpressionUSP5 [ NCBI-GEO ]   USP5 [ EBI - ARRAY_EXPRESS ]   USP5 [ SEEK ]   USP5 [ MEM ]
Gene Expression Viewer (FireBrowse)USP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8078
GTEX Portal (Tissue expression)USP5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP45974   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP45974  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP45974
Splice isoforms : SwissVarP45974
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusP45974
Domaine pattern : Prosite (Expaxy)UBA (PS50030)    USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)    ZF_UBP (PS50271)   
Domains : Interpro (EBI)Peptidase_C19_UCH    UBA    UBA-like    Ubiquitinyl_hydrolase    USP_CS    USP_dom    Znf_RING/FYVE/PHD    Znf_UBP   
Domain families : Pfam (Sanger)UBA (PF00627)    UCH (PF00443)    zf-UBP (PF02148)   
Domain families : Pfam (NCBI)pfam00627    pfam00443    pfam02148   
Domain families : Smart (EMBL)UBA (SM00165)  ZnF_UBP (SM00290)  
Conserved Domain (NCBI)USP5
DMDM Disease mutations8078
Blocks (Seattle)USP5
PDB (SRS)2DAG    2DAK    2G43    2G45    3IHP   
PDB (PDBSum)2DAG    2DAK    2G43    2G45    3IHP   
PDB (IMB)2DAG    2DAK    2G43    2G45    3IHP   
PDB (RSDB)2DAG    2DAK    2G43    2G45    3IHP   
Structural Biology KnowledgeBase2DAG    2DAK    2G43    2G45    3IHP   
SCOP (Structural Classification of Proteins)2DAG    2DAK    2G43    2G45    3IHP   
CATH (Classification of proteins structures)2DAG    2DAK    2G43    2G45    3IHP   
SuperfamilyP45974
Human Protein AtlasENSG00000111667
Peptide AtlasP45974
HPRD03265
IPIIPI00024664   IPI00375145   IPI01009973   
Protein Interaction databases
DIP (DOE-UCLA)P45974
IntAct (EBI)P45974
FunCoupENSG00000111667
BioGRIDUSP5
STRING (EMBL)USP5
ZODIACUSP5
Ontologies - Pathways
QuickGOP45974
Ontology : AmiGOcysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  protein binding  lysosome  cytosol  ubiquitin-dependent protein catabolic process  zinc ion binding  protein ubiquitination  protein deubiquitination  protein deubiquitination  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  thiol-dependent ubiquitinyl hydrolase activity  ubiquitin binding  protein K48-linked deubiquitination  
Ontology : EGO-EBIcysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  protein binding  lysosome  cytosol  ubiquitin-dependent protein catabolic process  zinc ion binding  protein ubiquitination  protein deubiquitination  protein deubiquitination  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  thiol-dependent ubiquitinyl hydrolase activity  ubiquitin binding  protein K48-linked deubiquitination  
NDEx NetworkUSP5
Atlas of Cancer Signalling NetworkUSP5
Wikipedia pathwaysUSP5
Orthology - Evolution
OrthoDB8078
GeneTree (enSembl)ENSG00000111667
Phylogenetic Trees/Animal Genes : TreeFamUSP5
HOVERGENP45974
HOGENOMP45974
Homologs : HomoloGeneUSP5
Homology/Alignments : Family Browser (UCSC)USP5
Gene fusions - Rearrangements
Fusion : MitelmanCOQ10A/USP5 [12q13.3/12p13.31]  [t(12;12)(p13;q13)]  
Fusion: TCGACOQ10A 12q13.3 USP5 12p13.31 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP5
dbVarUSP5
ClinVarUSP5
1000_GenomesUSP5 
Exome Variant ServerUSP5
ExAC (Exome Aggregation Consortium)USP5 (select the gene name)
Genetic variants : HAPMAP8078
Genomic Variants (DGV)USP5 [DGVbeta]
DECIPHERUSP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP5 
Mutations
ICGC Data PortalUSP5 
TCGA Data PortalUSP5 
Broad Tumor PortalUSP5
OASIS PortalUSP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP5
DgiDB (Drug Gene Interaction Database)USP5
DoCM (Curated mutations)USP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP5 (select a term)
intoGenUSP5
Cancer3DUSP5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601447   
Orphanet
MedgenUSP5
Genetic Testing Registry USP5
NextProtP45974 [Medical]
TSGene8078
GENETestsUSP5
Huge Navigator USP5 [HugePedia]
snp3D : Map Gene to Disease8078
BioCentury BCIQUSP5
ClinGenUSP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8078
Chemical/Pharm GKB GenePA37253
Clinical trialUSP5
Miscellaneous
canSAR (ICR)USP5 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP5
EVEXUSP5
GoPubMedUSP5
iHOPUSP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:43:37 CEST 2017

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