UTRN (utrophin)

2007-02-01  

Identity

HGNC
LOCATION
6q24.2
LOCUSID
ALIAS
DMDL,DRP,DRP1
FUSION GENES

Other Information

Locus ID:

NCBI: 7402
MIM: 128240
HGNC: 12635
Ensembl: ENSG00000152818

Variants:

dbSNP: 7402
ClinVar: 7402
TCGA: ENSG00000152818
COSMIC: UTRN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152818ENST00000367524H0Y337
ENSG00000152818ENST00000367525Q5T098
ENSG00000152818ENST00000367526Q5T097
ENSG00000152818ENST00000367545P46939
ENSG00000152818ENST00000417142Q5JT44
ENSG00000152818ENST00000421035A0A0A0MSM3
ENSG00000152818ENST00000432686Q5JT45
ENSG00000152818ENST00000433557Q5SYY2
ENSG00000152818ENST00000455022Q5JT49
ENSG00000152818ENST00000628146A0A0D9SG57

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124993522002Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.274
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
213262132011The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse.51
167106092006Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.49
203472652010MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia.34
233452122013Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death.28
160499732006Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients.27
206254232010Dystrophins, utrophins, and associated scaffolding complexes: role in mammalian brain and implications for therapeutic strategies.25
254345192015Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells.25
199454242010The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b.23

Citation

Dessen P

UTRN (utrophin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43837/utrn