Identity
HGNC
LOCATION
11q13.5
LOCUSID
ALIAS
DHTX,VPS38,p63
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7405
MIM: 602493
HGNC: 12640
Ensembl: ENSG00000198382
Variants:
dbSNP: 7405
ClinVar: 7405
TCGA: ENSG00000198382
COSMIC: UVRAG
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Autophagy - animal | KEGG | ko04140 |
| Autophagy - animal | KEGG | hsa04140 |
| Cellular responses to stress | REACTOME | R-HSA-2262752 |
| Macroautophagy | REACTOME | R-HSA-1632852 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38054642 | 2024 | UVRAG: orchestrating the initiation of reticulophagy. | 0 |
| 38054642 | 2024 | UVRAG: orchestrating the initiation of reticulophagy. | 0 |
| 34646380 | 2021 | TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG. | 34 |
| 34646380 | 2021 | TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG. | 34 |
| 30686098 | 2019 | Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. | 53 |
| 30894053 | 2019 | GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. | 32 |
| 30686098 | 2019 | Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. | 53 |
| 30894053 | 2019 | GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. | 32 |
| 28982601 | 2018 | miR-216b enhances the efficacy of vemurafenib by targeting Beclin-1, UVRAG and ATG5 in melanoma. | 16 |
| 29277783 | 2018 | Up-regulation of UVRAG by HDAC1 Inhibition Attenuates 5FU-induced Cell Death in HCT116 Colorectal Cancer Cells. | 12 |
| 29710477 | 2018 | miR-125b is downregulated in systemic lupus erythematosus patients and inhibits autophagy by targeting UVRAG. | 17 |
| 29866835 | 2018 | Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking. | 27 |
| 30061422 | 2018 | Central role of autophagic UVRAG in melanogenesis and the suntan response. | 15 |
| 30221685 | 2018 | miR-183 inhibits autophagy and apoptosis in gastric cancer cells by targeting ultraviolet radiation resistance-associated gene. | 15 |
| 28982601 | 2018 | miR-216b enhances the efficacy of vemurafenib by targeting Beclin-1, UVRAG and ATG5 in melanoma. | 16 |
Citation
Dessen P
UVRAG (UV radiation resistance associated)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42778/uvrag
