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VAMP2 (vesicle associated membrane protein 2)

Identity

Alias_namesSYB2
synaptobrevin 2
Alias_symbol (synonym)VAMP-2
Other alias
HGNC (Hugo) VAMP2
LocusID (NCBI) 6844
Atlas_Id 55772
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8062465 and ends at 8066293 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HNRNPD (4q21.22) / VAMP2 (17p13.1)STIM1 (11p15.4) / VAMP2 (17p13.1)VAMP2 (17p13.1) / ACTB (7p22.1)
VAMP2 (17p13.1) / CFAP20 (16q21)VAMP2 (17p13.1) / LGALS1 (22q13.1)VAMP2 (17p13.1) / TAF4 (20q13.33)
VAMP2 (17p13.1) / TNC (9q33.1)VAMP2 (17p13.1) / VAMP2 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q14;q23) KMT2A/PICALM::inv(11)(q14q23) KMT2A/PICALM


External links

Nomenclature
HGNC (Hugo)VAMP2   12643
Cards
Entrez_Gene (NCBI)VAMP2  6844  vesicle associated membrane protein 2
AliasesSYB2; VAMP-2
GeneCards (Weizmann)VAMP2
Ensembl hg19 (Hinxton)ENSG00000220205 [Gene_View]  chr17:8062465-8066293 [Contig_View]  VAMP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000220205 [Gene_View]  chr17:8062465-8066293 [Contig_View]  VAMP2 [Vega]
ICGC DataPortalENSG00000220205
TCGA cBioPortalVAMP2
AceView (NCBI)VAMP2
Genatlas (Paris)VAMP2
WikiGenes6844
SOURCE (Princeton)VAMP2
Genetics Home Reference (NIH)VAMP2
Genomic and cartography
GoldenPath hg19 (UCSC)VAMP2  -     chr17:8062465-8066293 -  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)VAMP2  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblVAMP2 - 17p13.1 [CytoView hg19]  VAMP2 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIVAMP2 [Mapview hg19]  VAMP2 [Mapview hg38]
OMIM185881   
Gene and transcription
Genbank (Entrez)AJ225044 AK021522 AK225777 AK289555 AL050223
RefSeq transcript (Entrez)NM_014232
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)VAMP2
Cluster EST : UnigeneHs.25348 [ NCBI ]
CGAP (NCI)Hs.25348
Alternative Splicing GalleryENSG00000220205
Gene ExpressionVAMP2 [ NCBI-GEO ]   VAMP2 [ EBI - ARRAY_EXPRESS ]   VAMP2 [ SEEK ]   VAMP2 [ MEM ]
Gene Expression Viewer (FireBrowse)VAMP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6844
GTEX Portal (Tissue expression)VAMP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63027   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63027  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63027
Splice isoforms : SwissVarP63027
PhosPhoSitePlusP63027
Domaine pattern : Prosite (Expaxy)SYNAPTOBREVIN (PS00417)    V_SNARE (PS50892)   
Domains : Interpro (EBI)Synaptobrevin    Synaptobrevin/VAMP   
Domain families : Pfam (Sanger)Synaptobrevin (PF00957)   
Domain families : Pfam (NCBI)pfam00957   
Conserved Domain (NCBI)VAMP2
DMDM Disease mutations6844
Blocks (Seattle)VAMP2
PDB (SRS)3FIE    3FII    3RK2    3RK3    3RL0   
PDB (PDBSum)3FIE    3FII    3RK2    3RK3    3RL0   
PDB (IMB)3FIE    3FII    3RK2    3RK3    3RL0   
PDB (RSDB)3FIE    3FII    3RK2    3RK3    3RL0   
Structural Biology KnowledgeBase3FIE    3FII    3RK2    3RK3    3RL0   
SCOP (Structural Classification of Proteins)3FIE    3FII    3RK2    3RK3    3RL0   
CATH (Classification of proteins structures)3FIE    3FII    3RK2    3RK3    3RL0   
SuperfamilyP63027
Human Protein AtlasENSG00000220205
Peptide AtlasP63027
HPRD01717
IPIIPI00553138   IPI00465395   IPI00790248   
Protein Interaction databases
DIP (DOE-UCLA)P63027
IntAct (EBI)P63027
FunCoupENSG00000220205
BioGRIDVAMP2
STRING (EMBL)VAMP2
ZODIACVAMP2
Ontologies - Pathways
QuickGOP63027
Ontology : AmiGOSNARE binding  storage vacuole  SNAP receptor activity  protein binding  calmodulin binding  phospholipid binding  trans-Golgi network  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  protein complex assembly  exocytosis  post-Golgi vesicle-mediated transport  vesicle fusion  neurotransmitter secretion  synaptic vesicle  synaptic vesicle  protein C-terminus binding  voltage-gated potassium channel complex  response to glucose  glutamate secretion  protein transport  membrane  synaptic vesicle exocytosis  synaptic vesicle exocytosis  vesicle-mediated transport  myosin binding  syntaxin-1 binding  calcium ion regulated exocytosis  regulation of exocytosis  syntaxin binding  syntaxin binding  cell junction  clathrin-coated vesicle  secretory granule  secretory granule membrane  secretory granule membrane  synaptic vesicle membrane  synaptic vesicle membrane  SNARE complex  SNARE complex  cytoplasmic vesicle  vesicle  protein complex binding  cellular response to insulin stimulus  zymogen granule membrane  identical protein binding  Golgi to plasma membrane protein transport  neuron projection  terminal bouton  intracellular membrane-bounded organelle  eosinophil degranulation  neutrophil degranulation  natural killer cell degranulation  protein self-association  neuron projection terminus  ion channel binding  synapse  calcium-dependent protein binding  perinuclear region of cytoplasm  clathrin-sculpted glutamate transport vesicle membrane  long-term synaptic potentiation  regulation of vesicle-mediated transport  membrane fusion  clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  synaptobrevin 2-SNAP-25-syntaxin-1a complex  extracellular exosome  clathrin-sculpted monoamine transport vesicle membrane  mucus secretion  positive regulation of intracellular protein transport  regulation of delayed rectifier potassium channel activity  regulation of histamine secretion by mast cell  
Ontology : EGO-EBISNARE binding  storage vacuole  SNAP receptor activity  protein binding  calmodulin binding  phospholipid binding  trans-Golgi network  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  protein complex assembly  exocytosis  post-Golgi vesicle-mediated transport  vesicle fusion  neurotransmitter secretion  synaptic vesicle  synaptic vesicle  protein C-terminus binding  voltage-gated potassium channel complex  response to glucose  glutamate secretion  protein transport  membrane  synaptic vesicle exocytosis  synaptic vesicle exocytosis  vesicle-mediated transport  myosin binding  syntaxin-1 binding  calcium ion regulated exocytosis  regulation of exocytosis  syntaxin binding  syntaxin binding  cell junction  clathrin-coated vesicle  secretory granule  secretory granule membrane  secretory granule membrane  synaptic vesicle membrane  synaptic vesicle membrane  SNARE complex  SNARE complex  cytoplasmic vesicle  vesicle  protein complex binding  cellular response to insulin stimulus  zymogen granule membrane  identical protein binding  Golgi to plasma membrane protein transport  neuron projection  terminal bouton  intracellular membrane-bounded organelle  eosinophil degranulation  neutrophil degranulation  natural killer cell degranulation  protein self-association  neuron projection terminus  ion channel binding  synapse  calcium-dependent protein binding  perinuclear region of cytoplasm  clathrin-sculpted glutamate transport vesicle membrane  long-term synaptic potentiation  regulation of vesicle-mediated transport  membrane fusion  clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  synaptobrevin 2-SNAP-25-syntaxin-1a complex  extracellular exosome  clathrin-sculpted monoamine transport vesicle membrane  mucus secretion  positive regulation of intracellular protein transport  regulation of delayed rectifier potassium channel activity  regulation of histamine secretion by mast cell  
Pathways : BIOCARTABlockade of Neurotransmitter Relase by Botulinum Toxin [Genes]   
Pathways : KEGGSNARE interactions in vesicular transport    Synaptic vesicle cycle    Insulin secretion    Vasopressin-regulated water reabsorption    Salivary secretion   
NDEx NetworkVAMP2
Atlas of Cancer Signalling NetworkVAMP2
Wikipedia pathwaysVAMP2
Orthology - Evolution
OrthoDB6844
GeneTree (enSembl)ENSG00000220205
Phylogenetic Trees/Animal Genes : TreeFamVAMP2
HOVERGENP63027
HOGENOMP63027
Homologs : HomoloGeneVAMP2
Homology/Alignments : Family Browser (UCSC)VAMP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVAMP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VAMP2
dbVarVAMP2
ClinVarVAMP2
1000_GenomesVAMP2 
Exome Variant ServerVAMP2
ExAC (Exome Aggregation Consortium)VAMP2 (select the gene name)
Genetic variants : HAPMAP6844
Genomic Variants (DGV)VAMP2 [DGVbeta]
DECIPHER (Syndromes)17:8062465-8066293  ENSG00000220205
CONAN: Copy Number AnalysisVAMP2 
Mutations
ICGC Data PortalVAMP2 
TCGA Data PortalVAMP2 
Broad Tumor PortalVAMP2
OASIS PortalVAMP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVAMP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVAMP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VAMP2
DgiDB (Drug Gene Interaction Database)VAMP2
DoCM (Curated mutations)VAMP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VAMP2 (select a term)
intoGenVAMP2
Cancer3DVAMP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM185881   
Orphanet
MedgenVAMP2
Genetic Testing Registry VAMP2
NextProtP63027 [Medical]
TSGene6844
GENETestsVAMP2
Huge Navigator VAMP2 [HugePedia]
snp3D : Map Gene to Disease6844
BioCentury BCIQVAMP2
ClinGenVAMP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6844
Chemical/Pharm GKB GenePA37267
Clinical trialVAMP2
Miscellaneous
canSAR (ICR)VAMP2 (select the gene name)
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVAMP2
EVEXVAMP2
GoPubMedVAMP2
iHOPVAMP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:33:45 CET 2017

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