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VAMP2 (vesicle associated membrane protein 2)

Identity

Alias (NCBI)NEDHAHM
SYB2
VAMP-2
HGNC (Hugo) VAMP2
HGNC Alias symbVAMP-2
HGNC Previous nameSYB2
HGNC Previous namesynaptobrevin 2
LocusID (NCBI) 6844
Atlas_Id 55772
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8159149 and ends at 8162948 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HNRNPD (4q21.22)::VAMP2 (17p13.1)STIM1 (11p15.4)::VAMP2 (17p13.1)VAMP2 (17p13.1)::ACTB (7p22.1)
VAMP2 (17p13.1)::CFAP20 (16q21)VAMP2 (17p13.1)::LGALS1 (22q13.1)VAMP2 (17p13.1)::TAF4 (20q13.33)
VAMP2 (17p13.1)::TNC (9q33.1)VAMP2 (17p13.1)::VAMP2 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q14;q23) KMT2A::PICALM::inv(11)(q14q23) KMT2A::PICALM


External links

 

Nomenclature
HGNC (Hugo)VAMP2   12643
Cards
Entrez_Gene (NCBI)VAMP2    vesicle associated membrane protein 2
AliasesNEDHAHM; SYB2; VAMP-2
GeneCards (Weizmann)VAMP2
Ensembl hg19 (Hinxton)ENSG00000220205 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000220205 [Gene_View]  ENSG00000220205 [Sequence]  chr17:8159149-8162948 [Contig_View]  VAMP2 [Vega]
ICGC DataPortalENSG00000220205
TCGA cBioPortalVAMP2
AceView (NCBI)VAMP2
Genatlas (Paris)VAMP2
SOURCE (Princeton)VAMP2
Genetics Home Reference (NIH)VAMP2
Genomic and cartography
GoldenPath hg38 (UCSC)VAMP2  -     chr17:8159149-8162948 -  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VAMP2  -     17p13.1   [Description]    (hg19-Feb_2009)
GoldenPathVAMP2 - 17p13.1 [CytoView hg19]  VAMP2 - 17p13.1 [CytoView hg38]
ImmunoBaseENSG00000220205
Genome Data Viewer NCBIVAMP2 [Mapview hg19]  
OMIM185881   618760   
Gene and transcription
Genbank (Entrez)AJ225044 AK021522 AK225777 AK289555 AL050223
RefSeq transcript (Entrez)NM_001330125 NM_014232
Consensus coding sequences : CCDS (NCBI)VAMP2
Gene ExpressionVAMP2 [ NCBI-GEO ]   VAMP2 [ EBI - ARRAY_EXPRESS ]   VAMP2 [ SEEK ]   VAMP2 [ MEM ]
Gene Expression Viewer (FireBrowse)VAMP2 [ Firebrowse - Broad ]
GenevisibleExpression of VAMP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6844
GTEX Portal (Tissue expression)VAMP2
Human Protein AtlasENSG00000220205-VAMP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63027   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63027  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63027
PhosPhoSitePlusP63027
Domaine pattern : Prosite (Expaxy)SYNAPTOBREVIN (PS00417)    V_SNARE (PS50892)   
Domains : Interpro (EBI)Synaptobrevin    Synaptobrevin/VAMP    V_SNARE_CC    VAMP2   
Domain families : Pfam (Sanger)Synaptobrevin (PF00957)   
Domain families : Pfam (NCBI)pfam00957   
Conserved Domain (NCBI)VAMP2
PDB (RSDB)3FIE    3FII    3RK2    3RK3    3RL0   
PDB Europe3FIE    3FII    3RK2    3RK3    3RL0   
PDB (PDBSum)3FIE    3FII    3RK2    3RK3    3RL0   
PDB (IMB)3FIE    3FII    3RK2    3RK3    3RL0   
Structural Biology KnowledgeBase3FIE    3FII    3RK2    3RK3    3RL0   
SCOP (Structural Classification of Proteins)3FIE    3FII    3RK2    3RK3    3RL0   
CATH (Classification of proteins structures)3FIE    3FII    3RK2    3RK3    3RL0   
SuperfamilyP63027
AlphaFold pdb e-kbP63027   
Human Protein Atlas [tissue]ENSG00000220205-VAMP2 [tissue]
HPRD01717
Protein Interaction databases
DIP (DOE-UCLA)P63027
IntAct (EBI)P63027
BioGRIDVAMP2
STRING (EMBL)VAMP2
ZODIACVAMP2
Ontologies - Pathways
QuickGOP63027
Ontology : AmiGOSNARE binding  SNAP receptor activity  protein binding  calmodulin binding  phospholipid binding  trans-Golgi network  cytosol  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  neurotransmitter transport  exocytosis  post-Golgi vesicle-mediated transport  vesicle fusion  vesicle fusion  neurotransmitter secretion  synaptic vesicle  synaptic vesicle  protein C-terminus binding  response to glucose  protein transport  membrane  synaptic vesicle exocytosis  synaptic vesicle exocytosis  vesicle-mediated transport  myosin binding  syntaxin-1 binding  syntaxin-1 binding  calcium-ion regulated exocytosis  regulation of exocytosis  syntaxin binding  syntaxin binding  syntaxin binding  clathrin-coated vesicle  secretory granule  integral component of synaptic vesicle membrane  secretory granule membrane  secretory granule membrane  clathrin-coated endocytic vesicle membrane  synaptic vesicle membrane  synaptic vesicle membrane  SNARE complex  SNARE complex  SNARE complex  cytoplasmic vesicle  vesicle  cellular response to insulin stimulus  SNARE complex assembly  zymogen granule membrane  identical protein binding  Golgi to plasma membrane protein transport  neuron projection  intracellular membrane-bounded organelle  eosinophil degranulation  neutrophil degranulation  natural killer cell degranulation  protein self-association  neuron projection terminus  ion channel binding  protein-containing complex binding  protein insertion into ER membrane  synapse  calcium-dependent protein binding  perinuclear region of cytoplasm  synaptic vesicle endocytosis  clathrin-sculpted glutamate transport vesicle membrane  long-term synaptic potentiation  regulation of vesicle-mediated transport  membrane organization  membrane fusion  clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  protein-containing complex assembly  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  synaptobrevin 2-SNAP-25-syntaxin-1a complex  clathrin-sculpted monoamine transport vesicle membrane  mucus secretion  positive regulation of intracellular protein transport  exocytic insertion of neurotransmitter receptor to postsynaptic membrane  regulation of delayed rectifier potassium channel activity  regulation of synaptic vesicle recycling  regulation of histamine secretion by mast cell  
Ontology : EGO-EBISNARE binding  SNAP receptor activity  protein binding  calmodulin binding  phospholipid binding  trans-Golgi network  cytosol  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  neurotransmitter transport  exocytosis  post-Golgi vesicle-mediated transport  vesicle fusion  vesicle fusion  neurotransmitter secretion  synaptic vesicle  synaptic vesicle  protein C-terminus binding  response to glucose  protein transport  membrane  synaptic vesicle exocytosis  synaptic vesicle exocytosis  vesicle-mediated transport  myosin binding  syntaxin-1 binding  syntaxin-1 binding  calcium-ion regulated exocytosis  regulation of exocytosis  syntaxin binding  syntaxin binding  syntaxin binding  clathrin-coated vesicle  secretory granule  integral component of synaptic vesicle membrane  secretory granule membrane  secretory granule membrane  clathrin-coated endocytic vesicle membrane  synaptic vesicle membrane  synaptic vesicle membrane  SNARE complex  SNARE complex  SNARE complex  cytoplasmic vesicle  vesicle  cellular response to insulin stimulus  SNARE complex assembly  zymogen granule membrane  identical protein binding  Golgi to plasma membrane protein transport  neuron projection  intracellular membrane-bounded organelle  eosinophil degranulation  neutrophil degranulation  natural killer cell degranulation  protein self-association  neuron projection terminus  ion channel binding  protein-containing complex binding  protein insertion into ER membrane  synapse  calcium-dependent protein binding  perinuclear region of cytoplasm  synaptic vesicle endocytosis  clathrin-sculpted glutamate transport vesicle membrane  long-term synaptic potentiation  regulation of vesicle-mediated transport  membrane organization  membrane fusion  clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  protein-containing complex assembly  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  synaptobrevin 2-SNAP-25-syntaxin-1a complex  clathrin-sculpted monoamine transport vesicle membrane  mucus secretion  positive regulation of intracellular protein transport  exocytic insertion of neurotransmitter receptor to postsynaptic membrane  regulation of delayed rectifier potassium channel activity  regulation of synaptic vesicle recycling  regulation of histamine secretion by mast cell  
Pathways : BIOCARTABlockade of Neurotransmitter Relase by Botulinum Toxin [Genes]   
Pathways : KEGGSNARE interactions in vesicular transport    Synaptic vesicle cycle    Insulin secretion    Vasopressin-regulated water reabsorption    Salivary secretion   
NDEx NetworkVAMP2
Atlas of Cancer Signalling NetworkVAMP2
Wikipedia pathwaysVAMP2
Orthology - Evolution
OrthoDB6844
GeneTree (enSembl)ENSG00000220205
Phylogenetic Trees/Animal Genes : TreeFamVAMP2
Homologs : HomoloGeneVAMP2
Homology/Alignments : Family Browser (UCSC)VAMP2
Gene fusions - Rearrangements
Fusion : QuiverVAMP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVAMP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VAMP2
dbVarVAMP2
ClinVarVAMP2
MonarchVAMP2
1000_GenomesVAMP2 
Exome Variant ServerVAMP2
GNOMAD BrowserENSG00000220205
Varsome BrowserVAMP2
ACMGVAMP2 variants
VarityP63027
Genomic Variants (DGV)VAMP2 [DGVbeta]
DECIPHERVAMP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVAMP2 
Mutations
ICGC Data PortalVAMP2 
TCGA Data PortalVAMP2 
Broad Tumor PortalVAMP2
OASIS PortalVAMP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVAMP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVAMP2
Mutations and Diseases : HGMDVAMP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaVAMP2
DgiDB (Drug Gene Interaction Database)VAMP2
DoCM (Curated mutations)VAMP2
CIViC (Clinical Interpretations of Variants in Cancer)VAMP2
Cancer3DVAMP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM185881    618760   
Orphanet
DisGeNETVAMP2
MedgenVAMP2
Genetic Testing Registry VAMP2
NextProtP63027 [Medical]
GENETestsVAMP2
Target ValidationVAMP2
Huge Navigator VAMP2 [HugePedia]
ClinGenVAMP2
Clinical trials, drugs, therapy
MyCancerGenomeVAMP2
Protein Interactions : CTDVAMP2
Pharm GKB GenePA37267
Pharm GKB PathwaysPA162355621   
PharosP63027
Clinical trialVAMP2
Miscellaneous
canSAR (ICR)VAMP2
HarmonizomeVAMP2
ARCHS4VAMP2
DataMed IndexVAMP2
Probes
Litterature
PubMed144 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXVAMP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:40:18 CET 2022

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