VAMP4 (vesicle associated membrane protein 4)

2016-10-01  

Identity

HGNC
VAMP4
LOCATION
1q24.3
LOCUSID
8674
ALIAS
VAMP-4,VAMP24

Other Information

Locus ID:

NCBI: 8674
MIM: 606909
HGNC: 12645
Ensembl: ENSG00000117533

Variants:

dbSNP: 8674
ClinVar: 8674
TCGA: ENSG00000117533
COSMIC: VAMP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117533ENST00000236192O75379
ENSG00000117533ENST00000236192Q6IAZ3
ENSG00000117533ENST00000367740O75379
ENSG00000117533ENST00000474047O75379
ENSG00000117533ENST00000474047Q6IAZ3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224065492012VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.69
218054682011VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells.21
235854722013ATP11B mediates platinum resistance in ovarian cancer.19
237413352013Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.12
237985382013Vesicle-associated membrane protein 4 and syntaxin 6 interactions at the chlamydial inclusion.12
236776962013VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.11
158966582005Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish.0

Citation

Dessen P

VAMP4 (vesicle associated membrane protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56459/vamp4