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VAMP7 (vesicle associated membrane protein 7)

Identity

Alias_namesSYBL1
synaptobrevin-like 1
Alias_symbol (synonym)VAMP-7
TI-VAMP
Other aliasTIVAMP
HGNC (Hugo) VAMP7
LocusID (NCBI) 6845
Atlas_Id 53320
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 155881280 and ends at 155943769 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q14;q23) KMT2A/PICALM::inv(11)(q14q23) KMT2A/PICALM


External links

Nomenclature
HGNC (Hugo)VAMP7   11486
Cards
Entrez_Gene (NCBI)VAMP7  6845  vesicle associated membrane protein 7
AliasesSYBL1; TI-VAMP; TIVAMP; VAMP-7
GeneCards (Weizmann)VAMP7
Ensembl hg19 (Hinxton)ENSG00000124333 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124333 [Gene_View]  chrX:155881280-155943769 [Contig_View]  VAMP7 [Vega]
ICGC DataPortalENSG00000124333
TCGA cBioPortalVAMP7
AceView (NCBI)VAMP7
Genatlas (Paris)VAMP7
WikiGenes6845
SOURCE (Princeton)VAMP7
Genetics Home Reference (NIH)VAMP7
Genomic and cartography
GoldenPath hg38 (UCSC)VAMP7  -     chrX:155881280-155943769 +  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VAMP7  -     Xq28   [Description]    (hg19-Feb_2009)
EnsemblVAMP7 - Xq28 [CytoView hg19]  VAMP7 - Xq28 [CytoView hg38]
Mapping of homologs : NCBIVAMP7 [Mapview hg19]  VAMP7 [Mapview hg38]
OMIM300053   
Gene and transcription
Genbank (Entrez)AI042181 AI522002 AJ295938 AJ549301 AK222794
RefSeq transcript (Entrez)NM_001145149 NM_001185183 NM_005638
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VAMP7
Cluster EST : UnigeneHs.24167 [ NCBI ]
CGAP (NCI)Hs.24167
Alternative Splicing GalleryENSG00000124333
Gene ExpressionVAMP7 [ NCBI-GEO ]   VAMP7 [ EBI - ARRAY_EXPRESS ]   VAMP7 [ SEEK ]   VAMP7 [ MEM ]
Gene Expression Viewer (FireBrowse)VAMP7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6845
GTEX Portal (Tissue expression)VAMP7
Human Protein AtlasENSG00000124333-VAMP7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51809   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51809  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51809
Splice isoforms : SwissVarP51809
PhosPhoSitePlusP51809
Domaine pattern : Prosite (Expaxy)LONGIN (PS50859)    SYNAPTOBREVIN (PS00417)    V_SNARE (PS50892)   
Domains : Interpro (EBI)Longin-like_dom    Longin_dom    Synaptobrevin   
Domain families : Pfam (Sanger)Longin (PF13774)    Synaptobrevin (PF00957)   
Domain families : Pfam (NCBI)pfam13774    pfam00957   
Domain families : Smart (EMBL)Longin (SM01270)  
Conserved Domain (NCBI)VAMP7
DMDM Disease mutations6845
Blocks (Seattle)VAMP7
PDB (SRS)2DMW   
PDB (PDBSum)2DMW   
PDB (IMB)2DMW   
PDB (RSDB)2DMW   
Structural Biology KnowledgeBase2DMW   
SCOP (Structural Classification of Proteins)2DMW   
CATH (Classification of proteins structures)2DMW   
SuperfamilyP51809
Human Protein Atlas [tissue]ENSG00000124333-VAMP7 [tissue]
Peptide AtlasP51809
HPRD02084
IPIIPI00020887   IPI00013236   IPI00401804   IPI00973966   
Protein Interaction databases
DIP (DOE-UCLA)P51809
IntAct (EBI)P51809
FunCoupENSG00000124333
BioGRIDVAMP7
STRING (EMBL)VAMP7
ZODIACVAMP7
Ontologies - Pathways
QuickGOP51809
Ontology : AmiGOSNARE binding  SNAP receptor activity  protein binding  cytoplasm  lysosome  lysosomal membrane  lysosomal membrane  lysosomal membrane  endoplasmic reticulum membrane  trans-Golgi network  plasma membrane  plasma membrane  ER to Golgi vesicle-mediated transport  post-Golgi vesicle-mediated transport  endocytosis  vesicle fusion  phagocytosis, engulfment  synaptic vesicle  endosome to lysosome transport  cell surface  membrane  vesicle-mediated transport  calcium ion regulated exocytosis  syntaxin binding  lamellipodium  cell junction  secretory granule  integral component of synaptic vesicle membrane  clathrin-coated vesicle membrane  secretory granule membrane  phagocytic vesicle membrane  platelet alpha granule  pseudopodium  SNARE complex  SNARE complex  late endosome membrane  triglyceride transport  SNARE complex assembly  azurophil granule membrane  Golgi to plasma membrane protein transport  neuron projection  intracellular membrane-bounded organelle  eosinophil degranulation  eosinophil degranulation  neutrophil degranulation  neutrophil degranulation  natural killer cell degranulation  apical part of cell  phagocytic vesicle  vesicle transport along microtubule  vesicle fusion with Golgi apparatus  perinuclear region of cytoplasm  positive regulation of dendrite morphogenesis  membrane organization  extracellular exosome  autophagosome maturation  regulation of protein targeting to vacuolar membrane  positive regulation of histamine secretion by mast cell  
Ontology : EGO-EBISNARE binding  SNAP receptor activity  protein binding  cytoplasm  lysosome  lysosomal membrane  lysosomal membrane  lysosomal membrane  endoplasmic reticulum membrane  trans-Golgi network  plasma membrane  plasma membrane  ER to Golgi vesicle-mediated transport  post-Golgi vesicle-mediated transport  endocytosis  vesicle fusion  phagocytosis, engulfment  synaptic vesicle  endosome to lysosome transport  cell surface  membrane  vesicle-mediated transport  calcium ion regulated exocytosis  syntaxin binding  lamellipodium  cell junction  secretory granule  integral component of synaptic vesicle membrane  clathrin-coated vesicle membrane  secretory granule membrane  phagocytic vesicle membrane  platelet alpha granule  pseudopodium  SNARE complex  SNARE complex  late endosome membrane  triglyceride transport  SNARE complex assembly  azurophil granule membrane  Golgi to plasma membrane protein transport  neuron projection  intracellular membrane-bounded organelle  eosinophil degranulation  eosinophil degranulation  neutrophil degranulation  neutrophil degranulation  natural killer cell degranulation  apical part of cell  phagocytic vesicle  vesicle transport along microtubule  vesicle fusion with Golgi apparatus  perinuclear region of cytoplasm  positive regulation of dendrite morphogenesis  membrane organization  extracellular exosome  autophagosome maturation  regulation of protein targeting to vacuolar membrane  positive regulation of histamine secretion by mast cell  
Pathways : KEGGSNARE interactions in vesicular transport   
NDEx NetworkVAMP7
Atlas of Cancer Signalling NetworkVAMP7
Wikipedia pathwaysVAMP7
Orthology - Evolution
OrthoDB6845
GeneTree (enSembl)ENSG00000124333
Phylogenetic Trees/Animal Genes : TreeFamVAMP7
HOVERGENP51809
HOGENOMP51809
Homologs : HomoloGeneVAMP7
Homology/Alignments : Family Browser (UCSC)VAMP7
Gene fusions - Rearrangements
Tumor Fusion PortalVAMP7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVAMP7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VAMP7
dbVarVAMP7
ClinVarVAMP7
1000_GenomesVAMP7 
Exome Variant ServerVAMP7
ExAC (Exome Aggregation Consortium)ENSG00000124333
GNOMAD BrowserENSG00000124333
Genetic variants : HAPMAP6845
Genomic Variants (DGV)VAMP7 [DGVbeta]
DECIPHERVAMP7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVAMP7 
Mutations
ICGC Data PortalVAMP7 
TCGA Data PortalVAMP7 
Broad Tumor PortalVAMP7
OASIS PortalVAMP7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVAMP7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVAMP7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch VAMP7
DgiDB (Drug Gene Interaction Database)VAMP7
DoCM (Curated mutations)VAMP7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VAMP7 (select a term)
intoGenVAMP7
Cancer3DVAMP7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300053   
Orphanet19642   
DisGeNETVAMP7
MedgenVAMP7
Genetic Testing Registry VAMP7
NextProtP51809 [Medical]
TSGene6845
GENETestsVAMP7
Target ValidationVAMP7
Huge Navigator VAMP7 [HugePedia]
snp3D : Map Gene to Disease6845
BioCentury BCIQVAMP7
ClinGenVAMP7 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6845
Chemical/Pharm GKB GenePA162408786
Clinical trialVAMP7
Miscellaneous
canSAR (ICR)VAMP7 (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVAMP7
EVEXVAMP7
GoPubMedVAMP7
iHOPVAMP7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:41:12 CET 2017

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