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VAMP7 (vesicle associated membrane protein 7)

Identity

Alias (NCBI)SYBL1
TI-VAMP
TIVAMP
VAMP-7
HGNC (Hugo) VAMP7
HGNC Alias symbVAMP-7
TI-VAMP
HGNC Previous nameSYBL1
HGNC Previous namesynaptobrevin-like 1
LocusID (NCBI) 6845
Atlas_Id 53320
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 155881345 and ends at 155943769 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q14;q23) KMT2A/PICALM::inv(11)(q14q23) KMT2A/PICALM


External links

 

Nomenclature
HGNC (Hugo)VAMP7   11486
Cards
Entrez_Gene (NCBI)VAMP7    vesicle associated membrane protein 7
AliasesSYBL1; TI-VAMP; TIVAMP; VAMP-7
GeneCards (Weizmann)VAMP7
Ensembl hg19 (Hinxton)ENSG00000124333 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124333 [Gene_View]  ENSG00000124333 [Sequence]  chrX:155881345-155943769 [Contig_View]  VAMP7 [Vega]
ICGC DataPortalENSG00000124333
TCGA cBioPortalVAMP7
AceView (NCBI)VAMP7
Genatlas (Paris)VAMP7
SOURCE (Princeton)VAMP7
Genetics Home Reference (NIH)VAMP7
Genomic and cartography
GoldenPath hg38 (UCSC)VAMP7  -     chrX:155881345-155943769 +  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VAMP7  -     Xq28   [Description]    (hg19-Feb_2009)
GoldenPathVAMP7 - Xq28 [CytoView hg19]  VAMP7 - Xq28 [CytoView hg38]
ImmunoBaseENSG00000124333
Genome Data Viewer NCBIVAMP7 [Mapview hg19]  
OMIM300053   
Gene and transcription
Genbank (Entrez)AI042181 AI522002 AJ295938 AJ549301 AK222794
RefSeq transcript (Entrez)NM_001145149 NM_001185183 NM_005638
Consensus coding sequences : CCDS (NCBI)VAMP7
Gene ExpressionVAMP7 [ NCBI-GEO ]   VAMP7 [ EBI - ARRAY_EXPRESS ]   VAMP7 [ SEEK ]   VAMP7 [ MEM ]
Gene Expression Viewer (FireBrowse)VAMP7 [ Firebrowse - Broad ]
GenevisibleExpression of VAMP7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6845
GTEX Portal (Tissue expression)VAMP7
Human Protein AtlasENSG00000124333-VAMP7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51809   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51809  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51809
PhosPhoSitePlusP51809
Domaine pattern : Prosite (Expaxy)LONGIN (PS50859)    SYNAPTOBREVIN (PS00417)    V_SNARE (PS50892)   
Domains : Interpro (EBI)Longin-like_dom_sf    Longin_dom    Synaptobrevin    V_SNARE_CC   
Domain families : Pfam (Sanger)Longin (PF13774)    Synaptobrevin (PF00957)   
Domain families : Pfam (NCBI)pfam13774    pfam00957   
Domain families : Smart (EMBL)Longin (SM01270)  
Conserved Domain (NCBI)VAMP7
PDB (RSDB)2DMW   
PDB Europe2DMW   
PDB (PDBSum)2DMW   
PDB (IMB)2DMW   
Structural Biology KnowledgeBase2DMW   
SCOP (Structural Classification of Proteins)2DMW   
CATH (Classification of proteins structures)2DMW   
SuperfamilyP51809
AlphaFold pdb e-kbP51809   
Human Protein Atlas [tissue]ENSG00000124333-VAMP7 [tissue]
HPRD02084
Protein Interaction databases
DIP (DOE-UCLA)P51809
IntAct (EBI)P51809
BioGRIDVAMP7
STRING (EMBL)VAMP7
ZODIACVAMP7
Ontologies - Pathways
QuickGOP51809
Ontology : AmiGOSNARE binding  SNAP receptor activity  protein binding  cytoplasm  lysosomal membrane  lysosomal membrane  lysosomal membrane  endoplasmic reticulum membrane  trans-Golgi network  plasma membrane  plasma membrane  exocytosis  endoplasmic reticulum to Golgi vesicle-mediated transport  post-Golgi vesicle-mediated transport  vesicle fusion  vesicle fusion  phagocytosis, engulfment  endosome to lysosome transport  endosome to lysosome transport  protein transport  membrane  vesicle-mediated transport  calcium-ion regulated exocytosis  syntaxin binding  lamellipodium  secretory granule  filopodium  integral component of synaptic vesicle membrane  secretory granule membrane  clathrin-coated endocytic vesicle membrane  phagocytic vesicle membrane  platelet alpha granule  pseudopodium  SNARE complex  SNARE complex  SNARE complex  late endosome membrane  triglyceride transport  azurophil granule membrane  neuron projection  intracellular membrane-bounded organelle  eosinophil degranulation  eosinophil degranulation  neutrophil degranulation  neutrophil degranulation  natural killer cell degranulation  phagocytic vesicle  vesicle transport along microtubule  vesicle fusion with Golgi apparatus  perinuclear region of cytoplasm  membrane organization  extracellular exosome  autophagosome maturation  hippocampal mossy fiber to CA3 synapse  positive regulation of histamine secretion by mast cell  
Ontology : EGO-EBISNARE binding  SNAP receptor activity  protein binding  cytoplasm  lysosomal membrane  lysosomal membrane  lysosomal membrane  endoplasmic reticulum membrane  trans-Golgi network  plasma membrane  plasma membrane  exocytosis  endoplasmic reticulum to Golgi vesicle-mediated transport  post-Golgi vesicle-mediated transport  vesicle fusion  vesicle fusion  phagocytosis, engulfment  endosome to lysosome transport  endosome to lysosome transport  protein transport  membrane  vesicle-mediated transport  calcium-ion regulated exocytosis  syntaxin binding  lamellipodium  secretory granule  filopodium  integral component of synaptic vesicle membrane  secretory granule membrane  clathrin-coated endocytic vesicle membrane  phagocytic vesicle membrane  platelet alpha granule  pseudopodium  SNARE complex  SNARE complex  SNARE complex  late endosome membrane  triglyceride transport  azurophil granule membrane  neuron projection  intracellular membrane-bounded organelle  eosinophil degranulation  eosinophil degranulation  neutrophil degranulation  neutrophil degranulation  natural killer cell degranulation  phagocytic vesicle  vesicle transport along microtubule  vesicle fusion with Golgi apparatus  perinuclear region of cytoplasm  membrane organization  extracellular exosome  autophagosome maturation  hippocampal mossy fiber to CA3 synapse  positive regulation of histamine secretion by mast cell  
Pathways : KEGGSNARE interactions in vesicular transport   
NDEx NetworkVAMP7
Atlas of Cancer Signalling NetworkVAMP7
Wikipedia pathwaysVAMP7
Orthology - Evolution
OrthoDB6845
GeneTree (enSembl)ENSG00000124333
Phylogenetic Trees/Animal Genes : TreeFamVAMP7
Homologs : HomoloGeneVAMP7
Homology/Alignments : Family Browser (UCSC)VAMP7
Gene fusions - Rearrangements
Fusion : QuiverVAMP7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVAMP7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VAMP7
dbVarVAMP7
ClinVarVAMP7
MonarchVAMP7
1000_GenomesVAMP7 
Exome Variant ServerVAMP7
GNOMAD BrowserENSG00000124333
Varsome BrowserVAMP7
ACMGVAMP7 variants
VarityP51809
Genomic Variants (DGV)VAMP7 [DGVbeta]
DECIPHERVAMP7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVAMP7 
Mutations
ICGC Data PortalVAMP7 
TCGA Data PortalVAMP7 
Broad Tumor PortalVAMP7
OASIS PortalVAMP7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVAMP7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVAMP7
Mutations and Diseases : HGMDVAMP7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaVAMP7
DgiDB (Drug Gene Interaction Database)VAMP7
DoCM (Curated mutations)VAMP7
CIViC (Clinical Interpretations of Variants in Cancer)VAMP7
Cancer3DVAMP7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300053   
Orphanet19642   
DisGeNETVAMP7
MedgenVAMP7
Genetic Testing Registry VAMP7
NextProtP51809 [Medical]
GENETestsVAMP7
Target ValidationVAMP7
Huge Navigator VAMP7 [HugePedia]
ClinGenVAMP7 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeVAMP7
Protein Interactions : CTDVAMP7
Pharm GKB GenePA162408786
PharosP51809
Clinical trialVAMP7
Miscellaneous
canSAR (ICR)VAMP7
HarmonizomeVAMP7
DataMed IndexVAMP7
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXVAMP7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:37:53 CEST 2021

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