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VAMP8 (vesicle associated membrane protein 8)

Identity

Alias_symbol (synonym)EDB
Other aliasVAMP-8
HGNC (Hugo) VAMP8
LocusID (NCBI) 8673
Atlas_Id 54765
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85577491 and ends at 85582033 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
VAMP8 (2p11.2) / SCAF1 (19q13.33)VAMP8 (2p11.2) / VAMP5 (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q14;q23) KMT2A/PICALM::inv(11)(q14q23) KMT2A/PICALM


External links

Nomenclature
HGNC (Hugo)VAMP8   12647
Cards
Entrez_Gene (NCBI)VAMP8  8673  vesicle associated membrane protein 8
AliasesEDB; VAMP-8
GeneCards (Weizmann)VAMP8
Ensembl hg19 (Hinxton)ENSG00000118640 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118640 [Gene_View]  chr2:85577491-85582033 [Contig_View]  VAMP8 [Vega]
ICGC DataPortalENSG00000118640
TCGA cBioPortalVAMP8
AceView (NCBI)VAMP8
Genatlas (Paris)VAMP8
WikiGenes8673
SOURCE (Princeton)VAMP8
Genetics Home Reference (NIH)VAMP8
Genomic and cartography
GoldenPath hg38 (UCSC)VAMP8  -     chr2:85577491-85582033 +  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VAMP8  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblVAMP8 - 2p11.2 [CytoView hg19]  VAMP8 - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBIVAMP8 [Mapview hg19]  VAMP8 [Mapview hg38]
OMIM603177   
Gene and transcription
Genbank (Entrez)AF053233 BC001634 BM702226 BQ227618 BT006700
RefSeq transcript (Entrez)NM_003761
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VAMP8
Cluster EST : UnigeneHs.714302 [ NCBI ]
CGAP (NCI)Hs.714302
Alternative Splicing GalleryENSG00000118640
Gene ExpressionVAMP8 [ NCBI-GEO ]   VAMP8 [ EBI - ARRAY_EXPRESS ]   VAMP8 [ SEEK ]   VAMP8 [ MEM ]
Gene Expression Viewer (FireBrowse)VAMP8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8673
GTEX Portal (Tissue expression)VAMP8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BV40   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BV40  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BV40
Splice isoforms : SwissVarQ9BV40
PhosPhoSitePlusQ9BV40
Domaine pattern : Prosite (Expaxy)SYNAPTOBREVIN (PS00417)    V_SNARE (PS50892)   
Domains : Interpro (EBI)Synaptobrevin    Synaptobrevin/VAMP   
Domain families : Pfam (Sanger)Synaptobrevin (PF00957)   
Domain families : Pfam (NCBI)pfam00957   
Conserved Domain (NCBI)VAMP8
DMDM Disease mutations8673
Blocks (Seattle)VAMP8
PDB (SRS)4WY4   
PDB (PDBSum)4WY4   
PDB (IMB)4WY4   
PDB (RSDB)4WY4   
Structural Biology KnowledgeBase4WY4   
SCOP (Structural Classification of Proteins)4WY4   
CATH (Classification of proteins structures)4WY4   
SuperfamilyQ9BV40
Human Protein AtlasENSG00000118640
Peptide AtlasQ9BV40
HPRD04415
IPIIPI00030911   IPI00917990   IPI00924720   
Protein Interaction databases
DIP (DOE-UCLA)Q9BV40
IntAct (EBI)Q9BV40
FunCoupENSG00000118640
BioGRIDVAMP8
STRING (EMBL)VAMP8
ZODIACVAMP8
Ontologies - Pathways
QuickGOQ9BV40
Ontology : AmiGOSNARE binding  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  SNAP receptor activity  protein binding  cytoplasm  lysosome  lysosomal membrane  early endosome  cytosol  plasma membrane  plasma membrane  post-Golgi vesicle-mediated transport  vesicle fusion  protein transport  membrane  integral component of membrane  autophagosome docking  chloride channel inhibitor activity  clathrin-coated vesicle membrane  secretory granule membrane  secretory granule membrane  phagocytic vesicle membrane  SNARE complex  early endosome membrane  late endosome membrane  vesicle  azurophil granule membrane  azurophil granule membrane  specific granule membrane  eosinophil degranulation  neutrophil degranulation  neutrophil degranulation  viral entry into host cell  perinuclear region of cytoplasm  recycling endosome  recycling endosome membrane  membrane organization  regulation of molecular function  extracellular exosome  mucus secretion  tertiary granule membrane  autophagosome maturation  mucin granule  regulation of protein localization to plasma membrane  negative regulation of secretion by cell  positive regulation of histamine secretion by mast cell  
Ontology : EGO-EBISNARE binding  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  SNAP receptor activity  protein binding  cytoplasm  lysosome  lysosomal membrane  early endosome  cytosol  plasma membrane  plasma membrane  post-Golgi vesicle-mediated transport  vesicle fusion  protein transport  membrane  integral component of membrane  autophagosome docking  chloride channel inhibitor activity  clathrin-coated vesicle membrane  secretory granule membrane  secretory granule membrane  phagocytic vesicle membrane  SNARE complex  early endosome membrane  late endosome membrane  vesicle  azurophil granule membrane  azurophil granule membrane  specific granule membrane  eosinophil degranulation  neutrophil degranulation  neutrophil degranulation  viral entry into host cell  perinuclear region of cytoplasm  recycling endosome  recycling endosome membrane  membrane organization  regulation of molecular function  extracellular exosome  mucus secretion  tertiary granule membrane  autophagosome maturation  mucin granule  regulation of protein localization to plasma membrane  negative regulation of secretion by cell  positive regulation of histamine secretion by mast cell  
Pathways : KEGGSNARE interactions in vesicular transport   
NDEx NetworkVAMP8
Atlas of Cancer Signalling NetworkVAMP8
Wikipedia pathwaysVAMP8
Orthology - Evolution
OrthoDB8673
GeneTree (enSembl)ENSG00000118640
Phylogenetic Trees/Animal Genes : TreeFamVAMP8
HOVERGENQ9BV40
HOGENOMQ9BV40
Homologs : HomoloGeneVAMP8
Homology/Alignments : Family Browser (UCSC)VAMP8
Gene fusions - Rearrangements
Fusion : MitelmanVAMP8/SCAF1 [2p11.2/19q13.33]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVAMP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VAMP8
dbVarVAMP8
ClinVarVAMP8
1000_GenomesVAMP8 
Exome Variant ServerVAMP8
ExAC (Exome Aggregation Consortium)VAMP8 (select the gene name)
Genetic variants : HAPMAP8673
Genomic Variants (DGV)VAMP8 [DGVbeta]
DECIPHERVAMP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVAMP8 
Mutations
ICGC Data PortalVAMP8 
TCGA Data PortalVAMP8 
Broad Tumor PortalVAMP8
OASIS PortalVAMP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVAMP8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVAMP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch VAMP8
DgiDB (Drug Gene Interaction Database)VAMP8
DoCM (Curated mutations)VAMP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VAMP8 (select a term)
intoGenVAMP8
Cancer3DVAMP8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603177   
Orphanet
MedgenVAMP8
Genetic Testing Registry VAMP8
NextProtQ9BV40 [Medical]
TSGene8673
GENETestsVAMP8
Target ValidationVAMP8
Huge Navigator VAMP8 [HugePedia]
snp3D : Map Gene to Disease8673
BioCentury BCIQVAMP8
ClinGenVAMP8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8673
Chemical/Pharm GKB GenePA37271
Clinical trialVAMP8
Miscellaneous
canSAR (ICR)VAMP8 (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVAMP8
EVEXVAMP8
GoPubMedVAMP8
iHOPVAMP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:02:22 CEST 2017

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