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VANGL1 (VANGL planar cell polarity protein 1)

Identity

Alias_namesvang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)
vang-like 1 (van gogh, Drosophila)
Alias_symbol (synonym)STB2
HGNC (Hugo) VANGL1
LocusID (NCBI) 81839
Atlas_Id 50805
Location 1p13.1  [Link to chromosome band 1p13]
Location_base_pair Starts at 116184574 and ends at 116240845 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP1A1 (1p13.1) / VANGL1 (1p13.1)MAN1A2 (1p12) / VANGL1 (1p13.1)VANGL1 (1p13.1) / HAO2 (1p12)
VANGL1 (1p13.1) / PARP12 (7q34)VANGL1 (1p13.1) / VANGL1 (1p13.1)ATP1A1 1p13.1 / VANGL1 1p13.1
MAN1A2 1p12 / VANGL1 1p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)VANGL1   15512
Cards
Entrez_Gene (NCBI)VANGL1  81839  VANGL planar cell polarity protein 1
AliasesKITENIN; LPP2; STB2; STBM2
GeneCards (Weizmann)VANGL1
Ensembl hg19 (Hinxton)ENSG00000173218 [Gene_View]  chr1:116184574-116240845 [Contig_View]  VANGL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000173218 [Gene_View]  chr1:116184574-116240845 [Contig_View]  VANGL1 [Vega]
ICGC DataPortalENSG00000173218
TCGA cBioPortalVANGL1
AceView (NCBI)VANGL1
Genatlas (Paris)VANGL1
WikiGenes81839
SOURCE (Princeton)VANGL1
Genetics Home Reference (NIH)VANGL1
Genomic and cartography
GoldenPath hg19 (UCSC)VANGL1  -     chr1:116184574-116240845 +  1p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)VANGL1  -     1p13.1   [Description]    (hg38-Dec_2013)
EnsemblVANGL1 - 1p13.1 [CytoView hg19]  VANGL1 - 1p13.1 [CytoView hg38]
Mapping of homologs : NCBIVANGL1 [Mapview hg19]  VANGL1 [Mapview hg38]
OMIM182940   600145   610132   
Gene and transcription
Genbank (Entrez)AB057596 AB075805 AF481859 AK312087 BC000907
RefSeq transcript (Entrez)NM_001172411 NM_001172412 NM_138959
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_016548 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)VANGL1
Cluster EST : UnigeneHs.515130 [ NCBI ]
CGAP (NCI)Hs.515130
Alternative Splicing GalleryENSG00000173218
Gene ExpressionVANGL1 [ NCBI-GEO ]   VANGL1 [ EBI - ARRAY_EXPRESS ]   VANGL1 [ SEEK ]   VANGL1 [ MEM ]
Gene Expression Viewer (FireBrowse)VANGL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81839
GTEX Portal (Tissue expression)VANGL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TAA9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TAA9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TAA9
Splice isoforms : SwissVarQ8TAA9
PhosPhoSitePlusQ8TAA9
Domains : Interpro (EBI)VANGL   
Domain families : Pfam (Sanger)Strabismus (PF06638)   
Domain families : Pfam (NCBI)pfam06638   
Conserved Domain (NCBI)VANGL1
DMDM Disease mutations81839
Blocks (Seattle)VANGL1
SuperfamilyQ8TAA9
Human Protein AtlasENSG00000173218
Peptide AtlasQ8TAA9
HPRD18279
IPIIPI00031195   IPI00386349   IPI00063848   
Protein Interaction databases
DIP (DOE-UCLA)Q8TAA9
IntAct (EBI)Q8TAA9
FunCoupENSG00000173218
BioGRIDVANGL1
STRING (EMBL)VANGL1
ZODIACVANGL1
Ontologies - Pathways
QuickGOQ8TAA9
Ontology : AmiGOprotein binding  multicellular organism development  integral component of membrane  lateral plasma membrane  Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIprotein binding  multicellular organism development  integral component of membrane  lateral plasma membrane  Wnt signaling pathway, planar cell polarity pathway  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkVANGL1
Atlas of Cancer Signalling NetworkVANGL1
Wikipedia pathwaysVANGL1
Orthology - Evolution
OrthoDB81839
GeneTree (enSembl)ENSG00000173218
Phylogenetic Trees/Animal Genes : TreeFamVANGL1
HOVERGENQ8TAA9
HOGENOMQ8TAA9
Homologs : HomoloGeneVANGL1
Homology/Alignments : Family Browser (UCSC)VANGL1
Gene fusions - Rearrangements
Fusion : MitelmanATP1A1/VANGL1 [1p13.1/1p13.1]  [t(1;1)(p13;p13)]  
Fusion : MitelmanMAN1A2/VANGL1 [1p12/1p13.1]  [t(1;1)(p12;p13)]  
Fusion : MitelmanVANGL1/HAO2 [1p13.1/1p12]  [t(1;1)(p12;p13)]  
Fusion: TCGAATP1A1 1p13.1 VANGL1 1p13.1 BRCA
Fusion: TCGAMAN1A2 1p12 VANGL1 1p13.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVANGL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VANGL1
dbVarVANGL1
ClinVarVANGL1
1000_GenomesVANGL1 
Exome Variant ServerVANGL1
ExAC (Exome Aggregation Consortium)VANGL1 (select the gene name)
Genetic variants : HAPMAP81839
Genomic Variants (DGV)VANGL1 [DGVbeta]
DECIPHER (Syndromes)1:116184574-116240845  ENSG00000173218
CONAN: Copy Number AnalysisVANGL1 
Mutations
ICGC Data PortalVANGL1 
TCGA Data PortalVANGL1 
Broad Tumor PortalVANGL1
OASIS PortalVANGL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVANGL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVANGL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VANGL1
DgiDB (Drug Gene Interaction Database)VANGL1
DoCM (Curated mutations)VANGL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VANGL1 (select a term)
intoGenVANGL1
Cancer3DVANGL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182940    600145    610132   
Orphanet946    20199    20198    20197    20196    20195    20194    20192    20188    20189    20190    20191    20187   
MedgenVANGL1
Genetic Testing Registry VANGL1
NextProtQ8TAA9 [Medical]
TSGene81839
GENETestsVANGL1
Huge Navigator VANGL1 [HugePedia]
snp3D : Map Gene to Disease81839
BioCentury BCIQVANGL1
ClinGenVANGL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81839
Chemical/Pharm GKB GenePA37971
Clinical trialVANGL1
Miscellaneous
canSAR (ICR)VANGL1 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVANGL1
EVEXVANGL1
GoPubMedVANGL1
iHOPVANGL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:55:31 CET 2016

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