VANGL2 (VANGL planar cell polarity protein 2)

2010-03-01  

Identity

HGNC
LOCATION
1q23.2
LOCUSID
ALIAS
LPP1,LTAP,STB1,STBM,STBM1
FUSION GENES

Other Information

Locus ID:

NCBI: 57216
MIM: 600533
HGNC: 15511
Ensembl: ENSG00000162738

Variants:

dbSNP: 57216
ClinVar: 57216
TCGA: ENSG00000162738
COSMIC: VANGL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162738ENST00000368061Q9ULK5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202237542010The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis.62
205583802010VANGL2 mutations in human cranial neural-tube defects.57
205583802010VANGL2 mutations in human cranial neural-tube defects.57
207383292011Contribution of VANGL2 mutations to isolated neural tube defects.37
233266402013A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network.35
267547712016Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.32
195773572010The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion.24
211421272011Loss of membrane targeting of Vangl proteins causes neural tube defects.14
294991542018Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.12
256277852015Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway.8

Citation

Dessen P

VANGL2 (VANGL planar cell polarity protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/52810/vangl2